Towards an effective sensing technology to monitor micro-scale interface loosening of bioelectronic implants

Abstract Instrumented implants are being developed with a radically innovative design to significantly reduce revision surgeries. Although bone replacements are among the most prevalent surgeries performed worldwide, implant failure rate usually surpasses 10%. High sophisticated multifunctional bioe...

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Autores principales:	Marco P. Soares dos Santos, Rodrigo Bernardo, Luís Henriques, A. Ramos, Jorge A. F. Ferreira, Edward P. Furlani, A. Torres Marques, José A. O. Simões
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6a94233afce94422aa303d4ce1bed0bf
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spelling	oai:doaj.org-article:6a94233afce94422aa303d4ce1bed0bf2021-12-02T12:09:18ZTowards an effective sensing technology to monitor micro-scale interface loosening of bioelectronic implants10.1038/s41598-021-82589-32045-2322https://doaj.org/article/6a94233afce94422aa303d4ce1bed0bf2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82589-3https://doaj.org/toc/2045-2322Abstract Instrumented implants are being developed with a radically innovative design to significantly reduce revision surgeries. Although bone replacements are among the most prevalent surgeries performed worldwide, implant failure rate usually surpasses 10%. High sophisticated multifunctional bioelectronic implants are being researched to incorporate cosurface capacitive architectures with ability to deliver personalized electric stimuli to peri-implant target tissues. However, the ability of these architectures to detect bone-implant interface states has never been explored. Moreover, although more than forty technologies were already proposed to detect implant loosening, none is able to ensure effective monitoring of the bone-implant debonding, mainly during the early stages of loosening. This work shows, for the first time, that cosurface capacitive sensors are a promising technology to provide an effective monitoring of bone-implant interfaces during the daily living of patients. Indeed, in vitro experimental tests and simulation with computational models highlight that both striped and circular capacitive architectures are able to detect micro-scale and macro-scale interface bonding, debonding or loosening, mainly when bonding is weakening or loosening is occurring. The proposed cosurface technologies hold potential to implement highly effective and personalized sensing systems such that the performance of multifunctional bioelectronic implants can be strongly improved. Findings were reported open a new research line on sensing technologies for bioelectronic implants, which may conduct to great impacts in the coming years.Marco P. Soares dos SantosRodrigo BernardoLuís HenriquesA. RamosJorge A. F. FerreiraEdward P. FurlaniA. Torres MarquesJosé A. O. SimõesNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marco P. Soares dos Santos Rodrigo Bernardo Luís Henriques A. Ramos Jorge A. F. Ferreira Edward P. Furlani A. Torres Marques José A. O. Simões Towards an effective sensing technology to monitor micro-scale interface loosening of bioelectronic implants
description	Abstract Instrumented implants are being developed with a radically innovative design to significantly reduce revision surgeries. Although bone replacements are among the most prevalent surgeries performed worldwide, implant failure rate usually surpasses 10%. High sophisticated multifunctional bioelectronic implants are being researched to incorporate cosurface capacitive architectures with ability to deliver personalized electric stimuli to peri-implant target tissues. However, the ability of these architectures to detect bone-implant interface states has never been explored. Moreover, although more than forty technologies were already proposed to detect implant loosening, none is able to ensure effective monitoring of the bone-implant debonding, mainly during the early stages of loosening. This work shows, for the first time, that cosurface capacitive sensors are a promising technology to provide an effective monitoring of bone-implant interfaces during the daily living of patients. Indeed, in vitro experimental tests and simulation with computational models highlight that both striped and circular capacitive architectures are able to detect micro-scale and macro-scale interface bonding, debonding or loosening, mainly when bonding is weakening or loosening is occurring. The proposed cosurface technologies hold potential to implement highly effective and personalized sensing systems such that the performance of multifunctional bioelectronic implants can be strongly improved. Findings were reported open a new research line on sensing technologies for bioelectronic implants, which may conduct to great impacts in the coming years.
format	article
author	Marco P. Soares dos Santos Rodrigo Bernardo Luís Henriques A. Ramos Jorge A. F. Ferreira Edward P. Furlani A. Torres Marques José A. O. Simões
author_facet	Marco P. Soares dos Santos Rodrigo Bernardo Luís Henriques A. Ramos Jorge A. F. Ferreira Edward P. Furlani A. Torres Marques José A. O. Simões
author_sort	Marco P. Soares dos Santos
title	Towards an effective sensing technology to monitor micro-scale interface loosening of bioelectronic implants
title_short	Towards an effective sensing technology to monitor micro-scale interface loosening of bioelectronic implants
title_full	Towards an effective sensing technology to monitor micro-scale interface loosening of bioelectronic implants
title_fullStr	Towards an effective sensing technology to monitor micro-scale interface loosening of bioelectronic implants
title_full_unstemmed	Towards an effective sensing technology to monitor micro-scale interface loosening of bioelectronic implants
title_sort	towards an effective sensing technology to monitor micro-scale interface loosening of bioelectronic implants
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6a94233afce94422aa303d4ce1bed0bf
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Towards an effective sensing technology to monitor micro-scale interface loosening of bioelectronic implants

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