Correlation between myocardial perfusion imaging findings and future cardiac events in patients with type 2 diabetes mellitus

Introduction/Objective. Myocardial perfusion imaging (MPI) is clinically useful for the evaluation of coronary artery disease in patients with diabetes mellitus. However, the prevalence of ischemia and its ability to predict future cardiac events is less clear. The aim was to determine the incidence...

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Autores principales:	Stanković Siniša, Šobić-Šaranović Dragana, Soldat-Stanković Valentina, Artiko Vera, Rajkovača Zvezdana, Mikač Gostimir, Egeljić-Mihailović Nataša, Majkić Marina
Formato:	article
Lenguaje:	EN SR
Publicado:	Serbian Medical Society 2021
Materias:	myocardial perfusion imaging diabetes mellitus coronary artery disease cardiac events Medicine R
Acceso en línea:	https://doaj.org/article/6a94e6c8ff0d425bb4fcad25cd1324e7
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spelling	oai:doaj.org-article:6a94e6c8ff0d425bb4fcad25cd1324e72021-11-10T07:28:09ZCorrelation between myocardial perfusion imaging findings and future cardiac events in patients with type 2 diabetes mellitus0370-81792406-089510.2298/SARH210329062Shttps://doaj.org/article/6a94e6c8ff0d425bb4fcad25cd1324e72021-01-01T00:00:00Zhttp://www.doiserbia.nb.rs/img/doi/0370-8179/2021/0370-81792100062S.pdfhttps://doaj.org/toc/0370-8179https://doaj.org/toc/2406-0895Introduction/Objective. Myocardial perfusion imaging (MPI) is clinically useful for the evaluation of coronary artery disease in patients with diabetes mellitus. However, the prevalence of ischemia and its ability to predict future cardiac events is less clear. The aim was to determine the incidence of cardiac events in diabetic patients and the relationship between them and MPI findings. Methods. Two cohorts of patients, 98 diabetics and 100 non-diabetics, with medium- to high-risk of coronary artery disease without previous coronary revascularization, were studied prospectively. All of them were outpatients who underwent 99mTc-sestamibi MPI with dipyridamole. The data about cardiac events were collected during a follow-up period of two years. Results. Cardiac events occurred in 17.3% diabetics and in 8% non-diabetics (p = 0.048). Diabetics had shorter estimated event-free time of 24.7 months (95% CI 23.2–26.2) versus non-diabetics’ estimated event-free time of 28.5 months (95% CI 27.4–29.5) (p = 0.046). The independent predictors of cardiac events were male sex (p = 0.010), previous myocardial infarction (p < 0.001), presence of the symptoms of angina (p = 0.014), and all variables derived from MPI findings. After adjustment for variables derived from MPI findings, the significant predictors in diabetics were the size of stress perfusion defect (p = 0.022), summed stress score (p = 0.011), and summed difference score (p = 0.044). Conclusion. In diabetic patients, the cumulative rate of cardiac events was higher and the event-free survival was worse. MPI could help in prediction of cardiac events in diabetics and the most important predictors were size of stress perfusion defect, summed stress score, and summed difference score.Stanković SinišaŠobić-Šaranović DraganaSoldat-Stanković ValentinaArtiko VeraRajkovača ZvezdanaMikač GostimirEgeljić-Mihailović NatašaMajkić MarinaSerbian Medical Societyarticlemyocardial perfusion imagingdiabetes mellituscoronary artery diseasecardiac eventsMedicineRENSRSrpski Arhiv za Celokupno Lekarstvo, Vol 149, Iss 9-10, Pp 585-590 (2021)
institution	DOAJ
collection	DOAJ
language	EN SR
topic	myocardial perfusion imaging diabetes mellitus coronary artery disease cardiac events Medicine R
spellingShingle	myocardial perfusion imaging diabetes mellitus coronary artery disease cardiac events Medicine R Stanković Siniša Šobić-Šaranović Dragana Soldat-Stanković Valentina Artiko Vera Rajkovača Zvezdana Mikač Gostimir Egeljić-Mihailović Nataša Majkić Marina Correlation between myocardial perfusion imaging findings and future cardiac events in patients with type 2 diabetes mellitus
description	Introduction/Objective. Myocardial perfusion imaging (MPI) is clinically useful for the evaluation of coronary artery disease in patients with diabetes mellitus. However, the prevalence of ischemia and its ability to predict future cardiac events is less clear. The aim was to determine the incidence of cardiac events in diabetic patients and the relationship between them and MPI findings. Methods. Two cohorts of patients, 98 diabetics and 100 non-diabetics, with medium- to high-risk of coronary artery disease without previous coronary revascularization, were studied prospectively. All of them were outpatients who underwent 99mTc-sestamibi MPI with dipyridamole. The data about cardiac events were collected during a follow-up period of two years. Results. Cardiac events occurred in 17.3% diabetics and in 8% non-diabetics (p = 0.048). Diabetics had shorter estimated event-free time of 24.7 months (95% CI 23.2–26.2) versus non-diabetics’ estimated event-free time of 28.5 months (95% CI 27.4–29.5) (p = 0.046). The independent predictors of cardiac events were male sex (p = 0.010), previous myocardial infarction (p < 0.001), presence of the symptoms of angina (p = 0.014), and all variables derived from MPI findings. After adjustment for variables derived from MPI findings, the significant predictors in diabetics were the size of stress perfusion defect (p = 0.022), summed stress score (p = 0.011), and summed difference score (p = 0.044). Conclusion. In diabetic patients, the cumulative rate of cardiac events was higher and the event-free survival was worse. MPI could help in prediction of cardiac events in diabetics and the most important predictors were size of stress perfusion defect, summed stress score, and summed difference score.
format	article
author	Stanković Siniša Šobić-Šaranović Dragana Soldat-Stanković Valentina Artiko Vera Rajkovača Zvezdana Mikač Gostimir Egeljić-Mihailović Nataša Majkić Marina
author_facet	Stanković Siniša Šobić-Šaranović Dragana Soldat-Stanković Valentina Artiko Vera Rajkovača Zvezdana Mikač Gostimir Egeljić-Mihailović Nataša Majkić Marina
author_sort	Stanković Siniša
title	Correlation between myocardial perfusion imaging findings and future cardiac events in patients with type 2 diabetes mellitus
title_short	Correlation between myocardial perfusion imaging findings and future cardiac events in patients with type 2 diabetes mellitus
title_full	Correlation between myocardial perfusion imaging findings and future cardiac events in patients with type 2 diabetes mellitus
title_fullStr	Correlation between myocardial perfusion imaging findings and future cardiac events in patients with type 2 diabetes mellitus
title_full_unstemmed	Correlation between myocardial perfusion imaging findings and future cardiac events in patients with type 2 diabetes mellitus
title_sort	correlation between myocardial perfusion imaging findings and future cardiac events in patients with type 2 diabetes mellitus
publisher	Serbian Medical Society
publishDate	2021
url	https://doaj.org/article/6a94e6c8ff0d425bb4fcad25cd1324e7
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Correlation between myocardial perfusion imaging findings and future cardiac events in patients with type 2 diabetes mellitus

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