Quantifying information accumulation encoded in the dynamics of biochemical signaling

Understanding how cells discriminate between stimuli is an ongoing challenge. Here, the authors propose a mathematical framework for inferring the mutual information encoded in temporal signaling dynamics and use it to study how information is transmitted over time in response to different stimuli i...

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Autores principales:	Ying Tang, Adewunmi Adelaja, Felix X.-F. Ye, Eric Deeds, Roy Wollman, Alexander Hoffmann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6a984b79447a4694b2b134c415de4df7
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spelling	oai:doaj.org-article:6a984b79447a4694b2b134c415de4df72021-12-02T13:32:50ZQuantifying information accumulation encoded in the dynamics of biochemical signaling10.1038/s41467-021-21562-02041-1723https://doaj.org/article/6a984b79447a4694b2b134c415de4df72021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21562-0https://doaj.org/toc/2041-1723Understanding how cells discriminate between stimuli is an ongoing challenge. Here, the authors propose a mathematical framework for inferring the mutual information encoded in temporal signaling dynamics and use it to study how information is transmitted over time in response to different stimuli in NFκB, MAPK and p53 signaling pathways.Ying TangAdewunmi AdelajaFelix X.-F. YeEric DeedsRoy WollmanAlexander HoffmannNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ying Tang Adewunmi Adelaja Felix X.-F. Ye Eric Deeds Roy Wollman Alexander Hoffmann Quantifying information accumulation encoded in the dynamics of biochemical signaling
description	Understanding how cells discriminate between stimuli is an ongoing challenge. Here, the authors propose a mathematical framework for inferring the mutual information encoded in temporal signaling dynamics and use it to study how information is transmitted over time in response to different stimuli in NFκB, MAPK and p53 signaling pathways.
format	article
author	Ying Tang Adewunmi Adelaja Felix X.-F. Ye Eric Deeds Roy Wollman Alexander Hoffmann
author_facet	Ying Tang Adewunmi Adelaja Felix X.-F. Ye Eric Deeds Roy Wollman Alexander Hoffmann
author_sort	Ying Tang
title	Quantifying information accumulation encoded in the dynamics of biochemical signaling
title_short	Quantifying information accumulation encoded in the dynamics of biochemical signaling
title_full	Quantifying information accumulation encoded in the dynamics of biochemical signaling
title_fullStr	Quantifying information accumulation encoded in the dynamics of biochemical signaling
title_full_unstemmed	Quantifying information accumulation encoded in the dynamics of biochemical signaling
title_sort	quantifying information accumulation encoded in the dynamics of biochemical signaling
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6a984b79447a4694b2b134c415de4df7
work_keys_str_mv	AT yingtang quantifyinginformationaccumulationencodedinthedynamicsofbiochemicalsignaling AT adewunmiadelaja quantifyinginformationaccumulationencodedinthedynamicsofbiochemicalsignaling AT felixxfye quantifyinginformationaccumulationencodedinthedynamicsofbiochemicalsignaling AT ericdeeds quantifyinginformationaccumulationencodedinthedynamicsofbiochemicalsignaling AT roywollman quantifyinginformationaccumulationencodedinthedynamicsofbiochemicalsignaling AT alexanderhoffmann quantifyinginformationaccumulationencodedinthedynamicsofbiochemicalsignaling
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Quantifying information accumulation encoded in the dynamics of biochemical signaling

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