Improved secretion of glycoproteins using an N-glycan-restricted passport sequence tag recognized by cargo receptor

Improved secretion of glycoproteins using an N-glycan-restricted passport sequence tag recognized by cargo receptor

The secretion of blood coagulation factor V and factor VIII (FV and FVIII) are driven by secretion factors ERGIC-53 and MCDF2. Here, the authors report a 10 amino acid motif from FVIII that can enhance secretion of another glycoprotein erythropoietin (EPO).

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Autores principales: Hirokazu Yagi, Maho Yagi-Utsumi, Rena Honda, Yusaku Ohta, Taiki Saito, Miho Nishio, Satoshi Ninagawa, Kousuke Suzuki, Takahiro Anzai, Yukiko Kamiya, Kazuhiro Aoki, Mahito Nakanishi, Tadashi Satoh, Koichi Kato
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/6a9a9c7e4540417ea33a586114d70dc4
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spelling oai:doaj.org-article:6a9a9c7e4540417ea33a586114d70dc42021-12-02T17:31:23ZImproved secretion of glycoproteins using an N-glycan-restricted passport sequence tag recognized by cargo receptor10.1038/s41467-020-15192-12041-1723https://doaj.org/article/6a9a9c7e4540417ea33a586114d70dc42020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15192-1https://doaj.org/toc/2041-1723The secretion of blood coagulation factor V and factor VIII (FV and FVIII) are driven by secretion factors ERGIC-53 and MCDF2. Here, the authors report a 10 amino acid motif from FVIII that can enhance secretion of another glycoprotein erythropoietin (EPO).Hirokazu YagiMaho Yagi-UtsumiRena HondaYusaku OhtaTaiki SaitoMiho NishioSatoshi NinagawaKousuke SuzukiTakahiro AnzaiYukiko KamiyaKazuhiro AokiMahito NakanishiTadashi SatohKoichi KatoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Hirokazu Yagi
Maho Yagi-Utsumi
Rena Honda
Yusaku Ohta
Taiki Saito
Miho Nishio
Satoshi Ninagawa
Kousuke Suzuki
Takahiro Anzai
Yukiko Kamiya
Kazuhiro Aoki
Mahito Nakanishi
Tadashi Satoh
Koichi Kato
Improved secretion of glycoproteins using an N-glycan-restricted passport sequence tag recognized by cargo receptor
description The secretion of blood coagulation factor V and factor VIII (FV and FVIII) are driven by secretion factors ERGIC-53 and MCDF2. Here, the authors report a 10 amino acid motif from FVIII that can enhance secretion of another glycoprotein erythropoietin (EPO).
format article
author Hirokazu Yagi
Maho Yagi-Utsumi
Rena Honda
Yusaku Ohta
Taiki Saito
Miho Nishio
Satoshi Ninagawa
Kousuke Suzuki
Takahiro Anzai
Yukiko Kamiya
Kazuhiro Aoki
Mahito Nakanishi
Tadashi Satoh
Koichi Kato
author_facet Hirokazu Yagi
Maho Yagi-Utsumi
Rena Honda
Yusaku Ohta
Taiki Saito
Miho Nishio
Satoshi Ninagawa
Kousuke Suzuki
Takahiro Anzai
Yukiko Kamiya
Kazuhiro Aoki
Mahito Nakanishi
Tadashi Satoh
Koichi Kato
author_sort Hirokazu Yagi
title Improved secretion of glycoproteins using an N-glycan-restricted passport sequence tag recognized by cargo receptor
title_short Improved secretion of glycoproteins using an N-glycan-restricted passport sequence tag recognized by cargo receptor
title_full Improved secretion of glycoproteins using an N-glycan-restricted passport sequence tag recognized by cargo receptor
title_fullStr Improved secretion of glycoproteins using an N-glycan-restricted passport sequence tag recognized by cargo receptor
title_full_unstemmed Improved secretion of glycoproteins using an N-glycan-restricted passport sequence tag recognized by cargo receptor
title_sort improved secretion of glycoproteins using an n-glycan-restricted passport sequence tag recognized by cargo receptor
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/6a9a9c7e4540417ea33a586114d70dc4
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