Structure of the initiation-competent RNA polymerase I and its implication for transcription

Eukaryotic RNA polymerase I (Pol I) is responsible for the transcription of rRNA genes. Here the authors determine the cryo-EM structure of the Pol I-Rrn3 complex, providing insight into how Rrn3 stabilizes the monomeric initiation competent Pol I to drive pre-initiation complex formation.

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Autores principales:	Michael Pilsl, Corinne Crucifix, Gabor Papai, Ferdinand Krupp, Robert Steinbauer, Joachim Griesenbeck, Philipp Milkereit, Herbert Tschochner, Patrick Schultz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6aa07fa9078d4b249ab94428a0822512
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spelling	oai:doaj.org-article:6aa07fa9078d4b249ab94428a08225122021-12-02T15:34:55ZStructure of the initiation-competent RNA polymerase I and its implication for transcription10.1038/ncomms121262041-1723https://doaj.org/article/6aa07fa9078d4b249ab94428a08225122016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12126https://doaj.org/toc/2041-1723Eukaryotic RNA polymerase I (Pol I) is responsible for the transcription of rRNA genes. Here the authors determine the cryo-EM structure of the Pol I-Rrn3 complex, providing insight into how Rrn3 stabilizes the monomeric initiation competent Pol I to drive pre-initiation complex formation.Michael PilslCorinne CrucifixGabor PapaiFerdinand KruppRobert SteinbauerJoachim GriesenbeckPhilipp MilkereitHerbert TschochnerPatrick SchultzNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael Pilsl Corinne Crucifix Gabor Papai Ferdinand Krupp Robert Steinbauer Joachim Griesenbeck Philipp Milkereit Herbert Tschochner Patrick Schultz Structure of the initiation-competent RNA polymerase I and its implication for transcription
description	Eukaryotic RNA polymerase I (Pol I) is responsible for the transcription of rRNA genes. Here the authors determine the cryo-EM structure of the Pol I-Rrn3 complex, providing insight into how Rrn3 stabilizes the monomeric initiation competent Pol I to drive pre-initiation complex formation.
format	article
author	Michael Pilsl Corinne Crucifix Gabor Papai Ferdinand Krupp Robert Steinbauer Joachim Griesenbeck Philipp Milkereit Herbert Tschochner Patrick Schultz
author_facet	Michael Pilsl Corinne Crucifix Gabor Papai Ferdinand Krupp Robert Steinbauer Joachim Griesenbeck Philipp Milkereit Herbert Tschochner Patrick Schultz
author_sort	Michael Pilsl
title	Structure of the initiation-competent RNA polymerase I and its implication for transcription
title_short	Structure of the initiation-competent RNA polymerase I and its implication for transcription
title_full	Structure of the initiation-competent RNA polymerase I and its implication for transcription
title_fullStr	Structure of the initiation-competent RNA polymerase I and its implication for transcription
title_full_unstemmed	Structure of the initiation-competent RNA polymerase I and its implication for transcription
title_sort	structure of the initiation-competent rna polymerase i and its implication for transcription
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/6aa07fa9078d4b249ab94428a0822512
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Structure of the initiation-competent RNA polymerase I and its implication for transcription

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