Ascension of Chlamydia is moderated by uterine peristalsis and the neutrophil response to infection.

Chlamydia trachomatis is a common sexually transmitted infection that is associated with a range of serious reproductive tract sequelae including in women Pelvic Inflammatory Disease (PID), tubal factor infertility, and ectopic pregnancy. Ascension of the pathogen beyond the cervix and into the uppe...

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Autores principales:	Torrington Callan, Stephen Woodcock, Wilhelmina May Huston
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/6aa0d832c79c48c0ac5d3a88a9f860bb
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spelling	oai:doaj.org-article:6aa0d832c79c48c0ac5d3a88a9f860bb2021-12-02T19:57:50ZAscension of Chlamydia is moderated by uterine peristalsis and the neutrophil response to infection.1553-734X1553-735810.1371/journal.pcbi.1009365https://doaj.org/article/6aa0d832c79c48c0ac5d3a88a9f860bb2021-09-01T00:00:00Zhttps://doi.org/10.1371/journal.pcbi.1009365https://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Chlamydia trachomatis is a common sexually transmitted infection that is associated with a range of serious reproductive tract sequelae including in women Pelvic Inflammatory Disease (PID), tubal factor infertility, and ectopic pregnancy. Ascension of the pathogen beyond the cervix and into the upper reproductive tract is thought to be necessary for these pathologies. However, Chlamydia trachomatis does not encode a mechanism for movement on its genome, and so the processes that facilitate ascension have not been elucidated. Here, we evaluate the factors that may influence chlamydial ascension in women. We constructed a mathematical model based on a set of stochastic dynamics to elucidate the moderating factors that might influence ascension of infections in the first month of an infection. In the simulations conducted from the stochastic model, 36% of infections ascended, but only 9% had more than 1000 bacteria ascend. The results of the simulations indicated that infectious load and the peristaltic contractions moderate ascension and are inter-related in impact. Smaller initial loads were much more likely to ascend. Ascension was found to be dependent on the neutrophil response. Overall, our results indicate that infectious load, menstrual cycle timing, and the neutrophil response are critical factors in chlamydial ascension in women.Torrington CallanStephen WoodcockWilhelmina May HustonPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 17, Iss 9, p e1009365 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Torrington Callan Stephen Woodcock Wilhelmina May Huston Ascension of Chlamydia is moderated by uterine peristalsis and the neutrophil response to infection.
description	Chlamydia trachomatis is a common sexually transmitted infection that is associated with a range of serious reproductive tract sequelae including in women Pelvic Inflammatory Disease (PID), tubal factor infertility, and ectopic pregnancy. Ascension of the pathogen beyond the cervix and into the upper reproductive tract is thought to be necessary for these pathologies. However, Chlamydia trachomatis does not encode a mechanism for movement on its genome, and so the processes that facilitate ascension have not been elucidated. Here, we evaluate the factors that may influence chlamydial ascension in women. We constructed a mathematical model based on a set of stochastic dynamics to elucidate the moderating factors that might influence ascension of infections in the first month of an infection. In the simulations conducted from the stochastic model, 36% of infections ascended, but only 9% had more than 1000 bacteria ascend. The results of the simulations indicated that infectious load and the peristaltic contractions moderate ascension and are inter-related in impact. Smaller initial loads were much more likely to ascend. Ascension was found to be dependent on the neutrophil response. Overall, our results indicate that infectious load, menstrual cycle timing, and the neutrophil response are critical factors in chlamydial ascension in women.
format	article
author	Torrington Callan Stephen Woodcock Wilhelmina May Huston
author_facet	Torrington Callan Stephen Woodcock Wilhelmina May Huston
author_sort	Torrington Callan
title	Ascension of Chlamydia is moderated by uterine peristalsis and the neutrophil response to infection.
title_short	Ascension of Chlamydia is moderated by uterine peristalsis and the neutrophil response to infection.
title_full	Ascension of Chlamydia is moderated by uterine peristalsis and the neutrophil response to infection.
title_fullStr	Ascension of Chlamydia is moderated by uterine peristalsis and the neutrophil response to infection.
title_full_unstemmed	Ascension of Chlamydia is moderated by uterine peristalsis and the neutrophil response to infection.
title_sort	ascension of chlamydia is moderated by uterine peristalsis and the neutrophil response to infection.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/6aa0d832c79c48c0ac5d3a88a9f860bb
work_keys_str_mv	AT torringtoncallan ascensionofchlamydiaismoderatedbyuterineperistalsisandtheneutrophilresponsetoinfection AT stephenwoodcock ascensionofchlamydiaismoderatedbyuterineperistalsisandtheneutrophilresponsetoinfection AT wilhelminamayhuston ascensionofchlamydiaismoderatedbyuterineperistalsisandtheneutrophilresponsetoinfection
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Ascension of Chlamydia is moderated by uterine peristalsis and the neutrophil response to infection.

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