Cooperative function of synaptophysin and synapsin in the generation of synaptic vesicle-like clusters in non-neuronal cells

Synaptic vesicle clusters were proposed to represent phase separated condensates. Here, the authors show that only two proteins, synapsin and synaptophysin, are sufficient to make vesicle clusters in fibroblasts which are similar to those found at synapses in morphology and liquid-like properties.

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Autores principales:	Daehun Park, Yumei Wu, Sang-Eun Lee, Goeun Kim, Seonyoung Jeong, Dragomir Milovanovic, Pietro De Camilli, Sunghoe Chang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6aa311dacba44c169f50903eb2d79e75
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spelling	oai:doaj.org-article:6aa311dacba44c169f50903eb2d79e752021-12-02T14:01:14ZCooperative function of synaptophysin and synapsin in the generation of synaptic vesicle-like clusters in non-neuronal cells10.1038/s41467-020-20462-z2041-1723https://doaj.org/article/6aa311dacba44c169f50903eb2d79e752021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20462-zhttps://doaj.org/toc/2041-1723Synaptic vesicle clusters were proposed to represent phase separated condensates. Here, the authors show that only two proteins, synapsin and synaptophysin, are sufficient to make vesicle clusters in fibroblasts which are similar to those found at synapses in morphology and liquid-like properties.Daehun ParkYumei WuSang-Eun LeeGoeun KimSeonyoung JeongDragomir MilovanovicPietro De CamilliSunghoe ChangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daehun Park Yumei Wu Sang-Eun Lee Goeun Kim Seonyoung Jeong Dragomir Milovanovic Pietro De Camilli Sunghoe Chang Cooperative function of synaptophysin and synapsin in the generation of synaptic vesicle-like clusters in non-neuronal cells
description	Synaptic vesicle clusters were proposed to represent phase separated condensates. Here, the authors show that only two proteins, synapsin and synaptophysin, are sufficient to make vesicle clusters in fibroblasts which are similar to those found at synapses in morphology and liquid-like properties.
format	article
author	Daehun Park Yumei Wu Sang-Eun Lee Goeun Kim Seonyoung Jeong Dragomir Milovanovic Pietro De Camilli Sunghoe Chang
author_facet	Daehun Park Yumei Wu Sang-Eun Lee Goeun Kim Seonyoung Jeong Dragomir Milovanovic Pietro De Camilli Sunghoe Chang
author_sort	Daehun Park
title	Cooperative function of synaptophysin and synapsin in the generation of synaptic vesicle-like clusters in non-neuronal cells
title_short	Cooperative function of synaptophysin and synapsin in the generation of synaptic vesicle-like clusters in non-neuronal cells
title_full	Cooperative function of synaptophysin and synapsin in the generation of synaptic vesicle-like clusters in non-neuronal cells
title_fullStr	Cooperative function of synaptophysin and synapsin in the generation of synaptic vesicle-like clusters in non-neuronal cells
title_full_unstemmed	Cooperative function of synaptophysin and synapsin in the generation of synaptic vesicle-like clusters in non-neuronal cells
title_sort	cooperative function of synaptophysin and synapsin in the generation of synaptic vesicle-like clusters in non-neuronal cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6aa311dacba44c169f50903eb2d79e75
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Cooperative function of synaptophysin and synapsin in the generation of synaptic vesicle-like clusters in non-neuronal cells

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