Smart Hydrogels – Synthetic Stimuli-Responsive Antitumor Drug Release Systems

Adam Kasiński, Monika Zielińska-Pisklak, Ewa Oledzka, Marcin Sobczak Department of Biomaterials Chemistry, Chair of Analytical Chemistry and Biomaterials, Faculty of Pharmacy, Medical University of Warsaw, Warsaw 02-097, PolandCorrespondence: Marcin Sobczak Tel +48-22-572-07-55Email marcin.sobczak@w...

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Autores principales:	Kasiński A, Zielińska-Pisklak M, Oledzka E, Sobczak M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	smart hydrogels stimuli-responsive hydrogels controlled release drug delivery systems anticancer drug delivery systems Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6aa3c4e2722f4f66936c6935c74ca6b5
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spelling	oai:doaj.org-article:6aa3c4e2722f4f66936c6935c74ca6b52021-12-02T10:06:28ZSmart Hydrogels – Synthetic Stimuli-Responsive Antitumor Drug Release Systems1178-2013https://doaj.org/article/6aa3c4e2722f4f66936c6935c74ca6b52020-06-01T00:00:00Zhttps://www.dovepress.com/smart-hydrogels-ndash-synthetic-stimuli-responsive-antitumor-drug-rele-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Adam Kasiński, Monika Zielińska-Pisklak, Ewa Oledzka, Marcin Sobczak Department of Biomaterials Chemistry, Chair of Analytical Chemistry and Biomaterials, Faculty of Pharmacy, Medical University of Warsaw, Warsaw 02-097, PolandCorrespondence: Marcin Sobczak Tel +48-22-572-07-55Email marcin.sobczak@wp.plAbstract: Among modern drug formulations, stimuli-responsive hydrogels also called “smart hydrogels” deserve a special attention. The basic feature of this system is the ability to change their mechanical properties, swelling ability, hydrophilicity, bioactive molecules permeability, etc., influenced by various stimuli, such as temperature, pH, electromagnetic radiation, magnetic field and biological factors. Therefore, stimuli-responsive matrices can be potentially used in tissue engineering, cell cultures and technology of innovative drug delivery systems (DDSs), releasing the active substances under the control of internal or external stimuli. Moreover, smart hydrogels can be used as injectable DDSs, due to gel–sol transition connected with in situ cross-linking process. Innovative smart hydrogel DDSs can be utilized as matrices for targeted therapy, which enhances the effectiveness of tumor chemotherapy and subsequently limits systemic toxicity. External stimulus sensitivity allows remote control over the drug release profile and gel formation. On the other hand, internal factors provide drg accumulation in tumor tissue and reduce the concentration of active drug form in healthy tissue. In this report, we summarise the basic knowledge and chemical strategies for the synthetic smart hydrogel DDSs applied in antitumor therapy.Keywords: smart hydrogels, stimuli-responsive hydrogels, controlled release, drug delivery systems, anticancer drug delivery systemsKasiński AZielińska-Pisklak MOledzka ESobczak MDove Medical Pressarticlesmart hydrogelsstimuli-responsive hydrogelscontrolled releasedrug delivery systemsanticancer drug delivery systemsMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 4541-4572 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	smart hydrogels stimuli-responsive hydrogels controlled release drug delivery systems anticancer drug delivery systems Medicine (General) R5-920
spellingShingle	smart hydrogels stimuli-responsive hydrogels controlled release drug delivery systems anticancer drug delivery systems Medicine (General) R5-920 Kasiński A Zielińska-Pisklak M Oledzka E Sobczak M Smart Hydrogels – Synthetic Stimuli-Responsive Antitumor Drug Release Systems
description	Adam Kasiński, Monika Zielińska-Pisklak, Ewa Oledzka, Marcin Sobczak Department of Biomaterials Chemistry, Chair of Analytical Chemistry and Biomaterials, Faculty of Pharmacy, Medical University of Warsaw, Warsaw 02-097, PolandCorrespondence: Marcin Sobczak Tel +48-22-572-07-55Email marcin.sobczak@wp.plAbstract: Among modern drug formulations, stimuli-responsive hydrogels also called “smart hydrogels” deserve a special attention. The basic feature of this system is the ability to change their mechanical properties, swelling ability, hydrophilicity, bioactive molecules permeability, etc., influenced by various stimuli, such as temperature, pH, electromagnetic radiation, magnetic field and biological factors. Therefore, stimuli-responsive matrices can be potentially used in tissue engineering, cell cultures and technology of innovative drug delivery systems (DDSs), releasing the active substances under the control of internal or external stimuli. Moreover, smart hydrogels can be used as injectable DDSs, due to gel–sol transition connected with in situ cross-linking process. Innovative smart hydrogel DDSs can be utilized as matrices for targeted therapy, which enhances the effectiveness of tumor chemotherapy and subsequently limits systemic toxicity. External stimulus sensitivity allows remote control over the drug release profile and gel formation. On the other hand, internal factors provide drg accumulation in tumor tissue and reduce the concentration of active drug form in healthy tissue. In this report, we summarise the basic knowledge and chemical strategies for the synthetic smart hydrogel DDSs applied in antitumor therapy.Keywords: smart hydrogels, stimuli-responsive hydrogels, controlled release, drug delivery systems, anticancer drug delivery systems
format	article
author	Kasiński A Zielińska-Pisklak M Oledzka E Sobczak M
author_facet	Kasiński A Zielińska-Pisklak M Oledzka E Sobczak M
author_sort	Kasiński A
title	Smart Hydrogels – Synthetic Stimuli-Responsive Antitumor Drug Release Systems
title_short	Smart Hydrogels – Synthetic Stimuli-Responsive Antitumor Drug Release Systems
title_full	Smart Hydrogels – Synthetic Stimuli-Responsive Antitumor Drug Release Systems
title_fullStr	Smart Hydrogels – Synthetic Stimuli-Responsive Antitumor Drug Release Systems
title_full_unstemmed	Smart Hydrogels – Synthetic Stimuli-Responsive Antitumor Drug Release Systems
title_sort	smart hydrogels – synthetic stimuli-responsive antitumor drug release systems
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/6aa3c4e2722f4f66936c6935c74ca6b5
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Smart Hydrogels &ndash; Synthetic Stimuli-Responsive Antitumor Drug Release Systems

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Smart Hydrogels – Synthetic Stimuli-Responsive Antitumor Drug Release Systems