Taxonomic profiling of skin microbiome and correlation with clinical skin parameters in healthy Koreans

Abstract The interest in skin microbiome differences by ethnicity, age, and gender is increasing. Compared to other ethnic groups, studies on the skin microbiome of Koreans remains insufficient; we investigated facial skin microbiome characteristics according to gender and age among Koreans. Fifty-o...

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Autores principales:	Ji-Hee Kim, Sang-Mo Son, Hyunjoon Park, Byoung Kook Kim, In Suk Choi, Heebal Kim, Chul Sung Huh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6aa4dc948ad645d28d42e6bb51abc265
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spelling	oai:doaj.org-article:6aa4dc948ad645d28d42e6bb51abc2652021-12-02T16:27:45ZTaxonomic profiling of skin microbiome and correlation with clinical skin parameters in healthy Koreans10.1038/s41598-021-95734-92045-2322https://doaj.org/article/6aa4dc948ad645d28d42e6bb51abc2652021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95734-9https://doaj.org/toc/2045-2322Abstract The interest in skin microbiome differences by ethnicity, age, and gender is increasing. Compared to other ethnic groups, studies on the skin microbiome of Koreans remains insufficient; we investigated facial skin microbiome characteristics according to gender and age among Koreans. Fifty-one healthy participants were recruited, the facial skin characteristics of each donor were investigated, their skin bacterial DNA was isolated and metagenomic analysis was performed. The donors were divided into two groups for age and sex each to analyze their skin microbiomes. Moreover, we investigated the correlation between the skin microbiome and clinical characteristics. The alpha diversity of the skin microbiome was significantly higher in the elderly, and beta diversity was significantly different according to age. The comparative skin microbials showed that the genus Lawsonella was more abundant in the younger age group, and Enhydrobacter was predominant in the older age group. Staphylococcus and Corynebacterium were more abundant in males, while Lactobacillus was more abundant in females. Lawsonella had a negative correlation with skin moisture and brown spots. Staphylococcus and Corynebacterium both had negative correlations with the number of UV spots and positive correlations with transepidermal water loss (TEWL). Furthermore, Staphylococcus aureus had a negative correlation with skin moisture parameters.Ji-Hee KimSang-Mo SonHyunjoon ParkByoung Kook KimIn Suk ChoiHeebal KimChul Sung HuhNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ji-Hee Kim Sang-Mo Son Hyunjoon Park Byoung Kook Kim In Suk Choi Heebal Kim Chul Sung Huh Taxonomic profiling of skin microbiome and correlation with clinical skin parameters in healthy Koreans
description	Abstract The interest in skin microbiome differences by ethnicity, age, and gender is increasing. Compared to other ethnic groups, studies on the skin microbiome of Koreans remains insufficient; we investigated facial skin microbiome characteristics according to gender and age among Koreans. Fifty-one healthy participants were recruited, the facial skin characteristics of each donor were investigated, their skin bacterial DNA was isolated and metagenomic analysis was performed. The donors were divided into two groups for age and sex each to analyze their skin microbiomes. Moreover, we investigated the correlation between the skin microbiome and clinical characteristics. The alpha diversity of the skin microbiome was significantly higher in the elderly, and beta diversity was significantly different according to age. The comparative skin microbials showed that the genus Lawsonella was more abundant in the younger age group, and Enhydrobacter was predominant in the older age group. Staphylococcus and Corynebacterium were more abundant in males, while Lactobacillus was more abundant in females. Lawsonella had a negative correlation with skin moisture and brown spots. Staphylococcus and Corynebacterium both had negative correlations with the number of UV spots and positive correlations with transepidermal water loss (TEWL). Furthermore, Staphylococcus aureus had a negative correlation with skin moisture parameters.
format	article
author	Ji-Hee Kim Sang-Mo Son Hyunjoon Park Byoung Kook Kim In Suk Choi Heebal Kim Chul Sung Huh
author_facet	Ji-Hee Kim Sang-Mo Son Hyunjoon Park Byoung Kook Kim In Suk Choi Heebal Kim Chul Sung Huh
author_sort	Ji-Hee Kim
title	Taxonomic profiling of skin microbiome and correlation with clinical skin parameters in healthy Koreans
title_short	Taxonomic profiling of skin microbiome and correlation with clinical skin parameters in healthy Koreans
title_full	Taxonomic profiling of skin microbiome and correlation with clinical skin parameters in healthy Koreans
title_fullStr	Taxonomic profiling of skin microbiome and correlation with clinical skin parameters in healthy Koreans
title_full_unstemmed	Taxonomic profiling of skin microbiome and correlation with clinical skin parameters in healthy Koreans
title_sort	taxonomic profiling of skin microbiome and correlation with clinical skin parameters in healthy koreans
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6aa4dc948ad645d28d42e6bb51abc265
work_keys_str_mv	AT jiheekim taxonomicprofilingofskinmicrobiomeandcorrelationwithclinicalskinparametersinhealthykoreans AT sangmoson taxonomicprofilingofskinmicrobiomeandcorrelationwithclinicalskinparametersinhealthykoreans AT hyunjoonpark taxonomicprofilingofskinmicrobiomeandcorrelationwithclinicalskinparametersinhealthykoreans AT byoungkookkim taxonomicprofilingofskinmicrobiomeandcorrelationwithclinicalskinparametersinhealthykoreans AT insukchoi taxonomicprofilingofskinmicrobiomeandcorrelationwithclinicalskinparametersinhealthykoreans AT heebalkim taxonomicprofilingofskinmicrobiomeandcorrelationwithclinicalskinparametersinhealthykoreans AT chulsunghuh taxonomicprofilingofskinmicrobiomeandcorrelationwithclinicalskinparametersinhealthykoreans
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Taxonomic profiling of skin microbiome and correlation with clinical skin parameters in healthy Koreans

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