Evaluation of thrombophilia testing in the inpatient setting: A single institution retrospective review.

<h4>Background</h4>Thrombophilia workup is typically inappropriate in the inpatient setting as testing may be skewed by anticoagulation, acute thrombosis, or acute illness.<h4>Objective</h4>To determine adherence of inpatient thrombophilia testing with institutional guideline...

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Autores principales:	Chun Ting Siu, Zachary Wolfe, Martin DelaTorre, Erafat Rehim, Robert Decker, Kathryn Zaffiri, Bradley Lash
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6aa6c16dcf3d4dee906cf73323c3e986
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spelling	oai:doaj.org-article:6aa6c16dcf3d4dee906cf73323c3e9862021-12-02T20:08:09ZEvaluation of thrombophilia testing in the inpatient setting: A single institution retrospective review.1932-620310.1371/journal.pone.0257687https://doaj.org/article/6aa6c16dcf3d4dee906cf73323c3e9862021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257687https://doaj.org/toc/1932-6203<h4>Background</h4>Thrombophilia workup is typically inappropriate in the inpatient setting as testing may be skewed by anticoagulation, acute thrombosis, or acute illness.<h4>Objective</h4>To determine adherence of inpatient thrombophilia testing with institutional guidelines.<h4>Patients and methods</h4>A retrospective study to evaluate thrombophilia testing practices of adult patients who were admitted to Lehigh Valley Hospital at Cedar Crest with either venous thromboembolism or ischemic stroke in 2019. Testing included inherited and acquired thrombophilia. Patient charts were individually reviewed for three measured outcomes: 1) the number of appropriate thrombophilia testing in the inpatient setting; 2) the indications used for thrombophilia testing; 3) the proportion of positive thrombophilia tests with change in clinical management.<h4>Results</h4>201 patients were included in our study. 26 patients (13%) were tested appropriately in accordance with institution guidelines and 175 (87%) patients were tested inappropriately. The most common reason for the inappropriate testing was testing during acute thrombosis. 28 of the 201 patients had positive thrombophilia tests, but the reviewers only noted 7 patients with change in clinical management-involving anticoagulation change.<h4>Conclusion</h4>Our study revealed that a majority of inpatient thrombophilia testing did not follow institutional guidelines for appropriate testing and did not change patient management. These thrombophilia tests are often overutilized and have minimal clinical utility in the inpatient setting.Chun Ting SiuZachary WolfeMartin DelaTorreErafat RehimRobert DeckerKathryn ZaffiriBradley LashPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0257687 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chun Ting Siu Zachary Wolfe Martin DelaTorre Erafat Rehim Robert Decker Kathryn Zaffiri Bradley Lash Evaluation of thrombophilia testing in the inpatient setting: A single institution retrospective review.
description	<h4>Background</h4>Thrombophilia workup is typically inappropriate in the inpatient setting as testing may be skewed by anticoagulation, acute thrombosis, or acute illness.<h4>Objective</h4>To determine adherence of inpatient thrombophilia testing with institutional guidelines.<h4>Patients and methods</h4>A retrospective study to evaluate thrombophilia testing practices of adult patients who were admitted to Lehigh Valley Hospital at Cedar Crest with either venous thromboembolism or ischemic stroke in 2019. Testing included inherited and acquired thrombophilia. Patient charts were individually reviewed for three measured outcomes: 1) the number of appropriate thrombophilia testing in the inpatient setting; 2) the indications used for thrombophilia testing; 3) the proportion of positive thrombophilia tests with change in clinical management.<h4>Results</h4>201 patients were included in our study. 26 patients (13%) were tested appropriately in accordance with institution guidelines and 175 (87%) patients were tested inappropriately. The most common reason for the inappropriate testing was testing during acute thrombosis. 28 of the 201 patients had positive thrombophilia tests, but the reviewers only noted 7 patients with change in clinical management-involving anticoagulation change.<h4>Conclusion</h4>Our study revealed that a majority of inpatient thrombophilia testing did not follow institutional guidelines for appropriate testing and did not change patient management. These thrombophilia tests are often overutilized and have minimal clinical utility in the inpatient setting.
format	article
author	Chun Ting Siu Zachary Wolfe Martin DelaTorre Erafat Rehim Robert Decker Kathryn Zaffiri Bradley Lash
author_facet	Chun Ting Siu Zachary Wolfe Martin DelaTorre Erafat Rehim Robert Decker Kathryn Zaffiri Bradley Lash
author_sort	Chun Ting Siu
title	Evaluation of thrombophilia testing in the inpatient setting: A single institution retrospective review.
title_short	Evaluation of thrombophilia testing in the inpatient setting: A single institution retrospective review.
title_full	Evaluation of thrombophilia testing in the inpatient setting: A single institution retrospective review.
title_fullStr	Evaluation of thrombophilia testing in the inpatient setting: A single institution retrospective review.
title_full_unstemmed	Evaluation of thrombophilia testing in the inpatient setting: A single institution retrospective review.
title_sort	evaluation of thrombophilia testing in the inpatient setting: a single institution retrospective review.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/6aa6c16dcf3d4dee906cf73323c3e986
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Evaluation of thrombophilia testing in the inpatient setting: A single institution retrospective review.

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