A Plasmodium yoelii HECT-like E3 ubiquitin ligase regulates parasite growth and virulence

Many strains of Plasmodium differ in virulence, but factors that control these distinctions are not known. Here the authors comparatively map virulence loci using the offspring from a P. yoelii YM and N67 genetic cross, and identify a putative HECT E3 ubiquitin ligase that may explain the variance.

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Autores principales:	Sethu C. Nair, Ruixue Xu, Sittiporn Pattaradilokrat, Jian Wu, Yanwei Qi, Martine Zilversmit, Sundar Ganesan, Vijayaraj Nagarajan, Richard T. Eastman, Marlene S. Orandle, John C. Tan, Timothy G. Myers, Shengfa Liu, Carole A. Long, Jian Li, Xin-zhuan Su
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6aa7760b2b7b4b8286e3d15932c22045
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spelling	oai:doaj.org-article:6aa7760b2b7b4b8286e3d15932c220452021-12-02T10:48:09ZA Plasmodium yoelii HECT-like E3 ubiquitin ligase regulates parasite growth and virulence10.1038/s41467-017-00267-32041-1723https://doaj.org/article/6aa7760b2b7b4b8286e3d15932c220452017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00267-3https://doaj.org/toc/2041-1723Many strains of Plasmodium differ in virulence, but factors that control these distinctions are not known. Here the authors comparatively map virulence loci using the offspring from a P. yoelii YM and N67 genetic cross, and identify a putative HECT E3 ubiquitin ligase that may explain the variance.Sethu C. NairRuixue XuSittiporn PattaradilokratJian WuYanwei QiMartine ZilversmitSundar GanesanVijayaraj NagarajanRichard T. EastmanMarlene S. OrandleJohn C. TanTimothy G. MyersShengfa LiuCarole A. LongJian LiXin-zhuan SuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sethu C. Nair Ruixue Xu Sittiporn Pattaradilokrat Jian Wu Yanwei Qi Martine Zilversmit Sundar Ganesan Vijayaraj Nagarajan Richard T. Eastman Marlene S. Orandle John C. Tan Timothy G. Myers Shengfa Liu Carole A. Long Jian Li Xin-zhuan Su A Plasmodium yoelii HECT-like E3 ubiquitin ligase regulates parasite growth and virulence
description	Many strains of Plasmodium differ in virulence, but factors that control these distinctions are not known. Here the authors comparatively map virulence loci using the offspring from a P. yoelii YM and N67 genetic cross, and identify a putative HECT E3 ubiquitin ligase that may explain the variance.
format	article
author	Sethu C. Nair Ruixue Xu Sittiporn Pattaradilokrat Jian Wu Yanwei Qi Martine Zilversmit Sundar Ganesan Vijayaraj Nagarajan Richard T. Eastman Marlene S. Orandle John C. Tan Timothy G. Myers Shengfa Liu Carole A. Long Jian Li Xin-zhuan Su
author_facet	Sethu C. Nair Ruixue Xu Sittiporn Pattaradilokrat Jian Wu Yanwei Qi Martine Zilversmit Sundar Ganesan Vijayaraj Nagarajan Richard T. Eastman Marlene S. Orandle John C. Tan Timothy G. Myers Shengfa Liu Carole A. Long Jian Li Xin-zhuan Su
author_sort	Sethu C. Nair
title	A Plasmodium yoelii HECT-like E3 ubiquitin ligase regulates parasite growth and virulence
title_short	A Plasmodium yoelii HECT-like E3 ubiquitin ligase regulates parasite growth and virulence
title_full	A Plasmodium yoelii HECT-like E3 ubiquitin ligase regulates parasite growth and virulence
title_fullStr	A Plasmodium yoelii HECT-like E3 ubiquitin ligase regulates parasite growth and virulence
title_full_unstemmed	A Plasmodium yoelii HECT-like E3 ubiquitin ligase regulates parasite growth and virulence
title_sort	plasmodium yoelii hect-like e3 ubiquitin ligase regulates parasite growth and virulence
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6aa7760b2b7b4b8286e3d15932c22045
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A Plasmodium yoelii HECT-like E3 ubiquitin ligase regulates parasite growth and virulence

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