B Cell Recognition of Candida albicans Hyphae via TLR 2 Promotes IgG1 and IL-6 Secretion for TH17 Differentiation

Candida albicans is usually a benign member of the human gut microbiota, but can become pathogenic under certain circumstances, for example in an immunocompromised host. The innate immune system, in particular neutrophils and macrophages, constitutes a crucial first line of defense against fungal in...

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Autores principales:	Marta Ferreira-Gomes, Melissa Wich, Sally Böde, Bernhard Hube, Ilse D. Jacobsen, Berit Jungnickel
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Candida albicans B cells toll-like receptors IL-6 TH17 cells fungal cell wall Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/6aaafc550f1c43f093d4748663671e7b
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spelling	oai:doaj.org-article:6aaafc550f1c43f093d4748663671e7b2021-11-08T05:55:26ZB Cell Recognition of Candida albicans Hyphae via TLR 2 Promotes IgG1 and IL-6 Secretion for TH17 Differentiation1664-322410.3389/fimmu.2021.698849https://doaj.org/article/6aaafc550f1c43f093d4748663671e7b2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.698849/fullhttps://doaj.org/toc/1664-3224Candida albicans is usually a benign member of the human gut microbiota, but can become pathogenic under certain circumstances, for example in an immunocompromised host. The innate immune system, in particular neutrophils and macrophages, constitutes a crucial first line of defense against fungal invasion, however adaptive immunity may provide long term protection and thus allow vaccination of at risk patients. While TH1 and TH17 cells are important for antifungal responses, the role of B cells and antibodies in protection from C. albicans infection is less well defined. In this study, we show that C. albicans hyphae but not yeast, as well as fungal cell wall components, directly activate B cells via MyD88 signaling triggered by Toll- like receptor 2, leading to increased IgG1 production. While Dectin-1 signals and specific recognition by the B cell receptor are dispensable for B cell activation in this system, TLR2/MyD88 signals cooperate with CD40 signals in promoting B cell activation. Importantly, recognition of C. albicans via MyD88 signaling is also essential for induction of IL-6 secretion by B cells, which promotes TH17 polarization in T-B cell coculture experiments. B cells may thus be activated directly by C. albicans in its invasive form, leading to production of antibodies and T cell help for fungal clearance.Marta Ferreira-GomesMelissa WichSally BödeBernhard HubeBernhard HubeIlse D. JacobsenIlse D. JacobsenBerit JungnickelFrontiers Media S.A.articleCandida albicansB cellstoll-like receptorsIL-6TH17 cellsfungal cell wallImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Candida albicans B cells toll-like receptors IL-6 TH17 cells fungal cell wall Immunologic diseases. Allergy RC581-607
spellingShingle	Candida albicans B cells toll-like receptors IL-6 TH17 cells fungal cell wall Immunologic diseases. Allergy RC581-607 Marta Ferreira-Gomes Melissa Wich Sally Böde Bernhard Hube Bernhard Hube Ilse D. Jacobsen Ilse D. Jacobsen Berit Jungnickel B Cell Recognition of Candida albicans Hyphae via TLR 2 Promotes IgG1 and IL-6 Secretion for TH17 Differentiation
description	Candida albicans is usually a benign member of the human gut microbiota, but can become pathogenic under certain circumstances, for example in an immunocompromised host. The innate immune system, in particular neutrophils and macrophages, constitutes a crucial first line of defense against fungal invasion, however adaptive immunity may provide long term protection and thus allow vaccination of at risk patients. While TH1 and TH17 cells are important for antifungal responses, the role of B cells and antibodies in protection from C. albicans infection is less well defined. In this study, we show that C. albicans hyphae but not yeast, as well as fungal cell wall components, directly activate B cells via MyD88 signaling triggered by Toll- like receptor 2, leading to increased IgG1 production. While Dectin-1 signals and specific recognition by the B cell receptor are dispensable for B cell activation in this system, TLR2/MyD88 signals cooperate with CD40 signals in promoting B cell activation. Importantly, recognition of C. albicans via MyD88 signaling is also essential for induction of IL-6 secretion by B cells, which promotes TH17 polarization in T-B cell coculture experiments. B cells may thus be activated directly by C. albicans in its invasive form, leading to production of antibodies and T cell help for fungal clearance.
format	article
author	Marta Ferreira-Gomes Melissa Wich Sally Böde Bernhard Hube Bernhard Hube Ilse D. Jacobsen Ilse D. Jacobsen Berit Jungnickel
author_facet	Marta Ferreira-Gomes Melissa Wich Sally Böde Bernhard Hube Bernhard Hube Ilse D. Jacobsen Ilse D. Jacobsen Berit Jungnickel
author_sort	Marta Ferreira-Gomes
title	B Cell Recognition of Candida albicans Hyphae via TLR 2 Promotes IgG1 and IL-6 Secretion for TH17 Differentiation
title_short	B Cell Recognition of Candida albicans Hyphae via TLR 2 Promotes IgG1 and IL-6 Secretion for TH17 Differentiation
title_full	B Cell Recognition of Candida albicans Hyphae via TLR 2 Promotes IgG1 and IL-6 Secretion for TH17 Differentiation
title_fullStr	B Cell Recognition of Candida albicans Hyphae via TLR 2 Promotes IgG1 and IL-6 Secretion for TH17 Differentiation
title_full_unstemmed	B Cell Recognition of Candida albicans Hyphae via TLR 2 Promotes IgG1 and IL-6 Secretion for TH17 Differentiation
title_sort	b cell recognition of candida albicans hyphae via tlr 2 promotes igg1 and il-6 secretion for th17 differentiation
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/6aaafc550f1c43f093d4748663671e7b
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B Cell Recognition of Candida albicans Hyphae via TLR 2 Promotes IgG1 and IL-6 Secretion for TH17 Differentiation

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