Plectranthus ecklonii Benth: A Comprehensive Review Into its Phytochemistry and Exerted Biological Activities

Ethnopharmacological Relevance:Plectranthus genus (Lamiaceae family) contain several species with acknowledged ethnopharmacological uses, such as, for gastrointestinal and respiratory-related problems, due to their anti-inflammatory, antibacterial and antifungal properties. The bioactivity of isolat...

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Autores principales:	Ana Ribeirinha Antão, Gabrielle Bangay, Eva María Domínguez-Martín, Ana María Díaz-Lanza, Patrícia Ríjo
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Plectranthus ecklonii phytochemistry pharmacology bioactivity plectranthus Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/6aae44d5082e4848a78f59717fcecba4
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spelling	oai:doaj.org-article:6aae44d5082e4848a78f59717fcecba42021-12-01T19:48:32ZPlectranthus ecklonii Benth: A Comprehensive Review Into its Phytochemistry and Exerted Biological Activities1663-981210.3389/fphar.2021.768268https://doaj.org/article/6aae44d5082e4848a78f59717fcecba42021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.768268/fullhttps://doaj.org/toc/1663-9812Ethnopharmacological Relevance:Plectranthus genus (Lamiaceae family) contain several species with acknowledged ethnopharmacological uses, such as, for gastrointestinal and respiratory-related problems, due to their anti-inflammatory, antibacterial and antifungal properties. The bioactivity of isolated medicinal compounds from this genus justifies the increased interest in recent times for species of Plectranthus, placing them in the spotlight for natural product drug development.Aim of the study: To the best of our knowledge, this is the first review on the biological activities of Plectranthus ecklonii Benth. As such, the aim of this review was three-fold: 1) to summarize the chemical compounds isolated from P. ecklonii; 2) to collate the biological activities and mechanisms of action of these compounds from in vitro studies; and 3) to evaluate the documented uses and potential applications of this species, in order to postulate on the direction of pharmaceutical uses of this species.Materials and methods: An extensive database retrieval was performed using the electronic databases Web of Science, PubMed, Google Scholar and ScienceDirect. The search criteria consisted of the keywords “Plectranthus ecklonii”, “Plectranthus ecklonii + review”, “Plectranthus ecklonii + diterpenes” or “Plectranthus ecklonii + abietanes”, “ecklonii + parviflorone D”, searched individually and as combinations. Eligibility criteria were set out and titles in English, Portuguese and Spanish were reviewed, with all references included dating from 1970 to 2021. A total of 169 papers were selected and included. Chemical structures were drawn using ChemDraw 20.0, CID numbers were searched in PubChem and the PRISMA diagram was created using PowerPoint 2012.Results: To date, a total of 28 compounds have been isolated from P. ecklonii, including diterpenes, triterpenes, flavonoids, and hydroxycinnamic acids. Most focused on the antimicrobial action of its constituents, although compounds have demonstrated other bioactivities, namely antioxidant, anti-inflammatory and antitumor. The most recent studies emphasize the diterpenoids, particularly parviflorone D, with the help of nanotechnology.Conclusions: The widespread ethnobotanical and traditional uses of P. ecklonii can be scientifically justified by a range of biological activities, demonstrated by isolated secondary metabolites. These bioactivities showcase the potential of this species in the development of economically important active pharmaceutical ingredients, particularly in anticancer therapy.Ana Ribeirinha AntãoGabrielle BangayGabrielle BangayEva María Domínguez-MartínEva María Domínguez-MartínAna María Díaz-LanzaPatrícia RíjoPatrícia RíjoFrontiers Media S.A.articlePlectranthus eckloniiphytochemistrypharmacologybioactivityplectranthusTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Plectranthus ecklonii phytochemistry pharmacology bioactivity plectranthus Therapeutics. Pharmacology RM1-950
spellingShingle	Plectranthus ecklonii phytochemistry pharmacology bioactivity plectranthus Therapeutics. Pharmacology RM1-950 Ana Ribeirinha Antão Gabrielle Bangay Gabrielle Bangay Eva María Domínguez-Martín Eva María Domínguez-Martín Ana María Díaz-Lanza Patrícia Ríjo Patrícia Ríjo Plectranthus ecklonii Benth: A Comprehensive Review Into its Phytochemistry and Exerted Biological Activities
description	Ethnopharmacological Relevance:Plectranthus genus (Lamiaceae family) contain several species with acknowledged ethnopharmacological uses, such as, for gastrointestinal and respiratory-related problems, due to their anti-inflammatory, antibacterial and antifungal properties. The bioactivity of isolated medicinal compounds from this genus justifies the increased interest in recent times for species of Plectranthus, placing them in the spotlight for natural product drug development.Aim of the study: To the best of our knowledge, this is the first review on the biological activities of Plectranthus ecklonii Benth. As such, the aim of this review was three-fold: 1) to summarize the chemical compounds isolated from P. ecklonii; 2) to collate the biological activities and mechanisms of action of these compounds from in vitro studies; and 3) to evaluate the documented uses and potential applications of this species, in order to postulate on the direction of pharmaceutical uses of this species.Materials and methods: An extensive database retrieval was performed using the electronic databases Web of Science, PubMed, Google Scholar and ScienceDirect. The search criteria consisted of the keywords “Plectranthus ecklonii”, “Plectranthus ecklonii + review”, “Plectranthus ecklonii + diterpenes” or “Plectranthus ecklonii + abietanes”, “ecklonii + parviflorone D”, searched individually and as combinations. Eligibility criteria were set out and titles in English, Portuguese and Spanish were reviewed, with all references included dating from 1970 to 2021. A total of 169 papers were selected and included. Chemical structures were drawn using ChemDraw 20.0, CID numbers were searched in PubChem and the PRISMA diagram was created using PowerPoint 2012.Results: To date, a total of 28 compounds have been isolated from P. ecklonii, including diterpenes, triterpenes, flavonoids, and hydroxycinnamic acids. Most focused on the antimicrobial action of its constituents, although compounds have demonstrated other bioactivities, namely antioxidant, anti-inflammatory and antitumor. The most recent studies emphasize the diterpenoids, particularly parviflorone D, with the help of nanotechnology.Conclusions: The widespread ethnobotanical and traditional uses of P. ecklonii can be scientifically justified by a range of biological activities, demonstrated by isolated secondary metabolites. These bioactivities showcase the potential of this species in the development of economically important active pharmaceutical ingredients, particularly in anticancer therapy.
format	article
author	Ana Ribeirinha Antão Gabrielle Bangay Gabrielle Bangay Eva María Domínguez-Martín Eva María Domínguez-Martín Ana María Díaz-Lanza Patrícia Ríjo Patrícia Ríjo
author_facet	Ana Ribeirinha Antão Gabrielle Bangay Gabrielle Bangay Eva María Domínguez-Martín Eva María Domínguez-Martín Ana María Díaz-Lanza Patrícia Ríjo Patrícia Ríjo
author_sort	Ana Ribeirinha Antão
title	Plectranthus ecklonii Benth: A Comprehensive Review Into its Phytochemistry and Exerted Biological Activities
title_short	Plectranthus ecklonii Benth: A Comprehensive Review Into its Phytochemistry and Exerted Biological Activities
title_full	Plectranthus ecklonii Benth: A Comprehensive Review Into its Phytochemistry and Exerted Biological Activities
title_fullStr	Plectranthus ecklonii Benth: A Comprehensive Review Into its Phytochemistry and Exerted Biological Activities
title_full_unstemmed	Plectranthus ecklonii Benth: A Comprehensive Review Into its Phytochemistry and Exerted Biological Activities
title_sort	plectranthus ecklonii benth: a comprehensive review into its phytochemistry and exerted biological activities
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/6aae44d5082e4848a78f59717fcecba4
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Plectranthus ecklonii Benth: A Comprehensive Review Into its Phytochemistry and Exerted Biological Activities

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