LOTUS, an endogenous Nogo receptor antagonist, is involved in synapse and memory formation

Abstract The Nogo signal is involved in impairment of memory formation. We previously reported the lateral olfactory tract usher substance (LOTUS) as an endogenous antagonist of the Nogo receptor 1 that mediates the inhibition of axon growth and synapse formation. Moreover, we found that LOTUS plays...

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Autores principales:	Ryohei Nishida, Yuki Kawaguchi, Junpei Matsubayashi, Rie Ishikawa, Satoshi Kida, Kohtaro Takei
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6aaf9a273c9f4efcbcead20df26e163d
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spelling	oai:doaj.org-article:6aaf9a273c9f4efcbcead20df26e163d2021-12-02T11:37:27ZLOTUS, an endogenous Nogo receptor antagonist, is involved in synapse and memory formation10.1038/s41598-021-84106-y2045-2322https://doaj.org/article/6aaf9a273c9f4efcbcead20df26e163d2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84106-yhttps://doaj.org/toc/2045-2322Abstract The Nogo signal is involved in impairment of memory formation. We previously reported the lateral olfactory tract usher substance (LOTUS) as an endogenous antagonist of the Nogo receptor 1 that mediates the inhibition of axon growth and synapse formation. Moreover, we found that LOTUS plays an essential role in neural circuit formation and nerve regeneration. However, the effects of LOTUS on synapse formation and memory function have not been elucidated. Here, we clearly showed the involvement of LOTUS in synapse formation and memory function. The cultured hippocampal neurons derived from lotus gene knockout (LOTUS-KO) mice exhibited a decrease in synaptic density compared with those from wild-type mice. We also found decrease of dendritic spine formation in the adult hippocampus of LOTUS-KO mice. Finally, we demonstrated that LOTUS deficiency impairs memory formation in the social recognition test and the Morris water maze test, indicating that LOTUS is involved in functions of social and spatial learning and memory. These findings suggest that LOTUS affects synapse formation and memory function.Ryohei NishidaYuki KawaguchiJunpei MatsubayashiRie IshikawaSatoshi KidaKohtaro TakeiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ryohei Nishida Yuki Kawaguchi Junpei Matsubayashi Rie Ishikawa Satoshi Kida Kohtaro Takei LOTUS, an endogenous Nogo receptor antagonist, is involved in synapse and memory formation
description	Abstract The Nogo signal is involved in impairment of memory formation. We previously reported the lateral olfactory tract usher substance (LOTUS) as an endogenous antagonist of the Nogo receptor 1 that mediates the inhibition of axon growth and synapse formation. Moreover, we found that LOTUS plays an essential role in neural circuit formation and nerve regeneration. However, the effects of LOTUS on synapse formation and memory function have not been elucidated. Here, we clearly showed the involvement of LOTUS in synapse formation and memory function. The cultured hippocampal neurons derived from lotus gene knockout (LOTUS-KO) mice exhibited a decrease in synaptic density compared with those from wild-type mice. We also found decrease of dendritic spine formation in the adult hippocampus of LOTUS-KO mice. Finally, we demonstrated that LOTUS deficiency impairs memory formation in the social recognition test and the Morris water maze test, indicating that LOTUS is involved in functions of social and spatial learning and memory. These findings suggest that LOTUS affects synapse formation and memory function.
format	article
author	Ryohei Nishida Yuki Kawaguchi Junpei Matsubayashi Rie Ishikawa Satoshi Kida Kohtaro Takei
author_facet	Ryohei Nishida Yuki Kawaguchi Junpei Matsubayashi Rie Ishikawa Satoshi Kida Kohtaro Takei
author_sort	Ryohei Nishida
title	LOTUS, an endogenous Nogo receptor antagonist, is involved in synapse and memory formation
title_short	LOTUS, an endogenous Nogo receptor antagonist, is involved in synapse and memory formation
title_full	LOTUS, an endogenous Nogo receptor antagonist, is involved in synapse and memory formation
title_fullStr	LOTUS, an endogenous Nogo receptor antagonist, is involved in synapse and memory formation
title_full_unstemmed	LOTUS, an endogenous Nogo receptor antagonist, is involved in synapse and memory formation
title_sort	lotus, an endogenous nogo receptor antagonist, is involved in synapse and memory formation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6aaf9a273c9f4efcbcead20df26e163d
work_keys_str_mv	AT ryoheinishida lotusanendogenousnogoreceptorantagonistisinvolvedinsynapseandmemoryformation AT yukikawaguchi lotusanendogenousnogoreceptorantagonistisinvolvedinsynapseandmemoryformation AT junpeimatsubayashi lotusanendogenousnogoreceptorantagonistisinvolvedinsynapseandmemoryformation AT rieishikawa lotusanendogenousnogoreceptorantagonistisinvolvedinsynapseandmemoryformation AT satoshikida lotusanendogenousnogoreceptorantagonistisinvolvedinsynapseandmemoryformation AT kohtarotakei lotusanendogenousnogoreceptorantagonistisinvolvedinsynapseandmemoryformation
_version_	1718395763391725568

LOTUS, an endogenous Nogo receptor antagonist, is involved in synapse and memory formation

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