Gender Differences in the Relationship of Waist Circumference to Coronary Artery Lesions and One-Year Re-Admission Among Coronary Artery Disease Patients with Normal Body Mass Index

Hui Luan,1 Yan Song,2 Lifei Cao,1 Ping Wang,1 Danjun Zhu,1 Gang Tian1 1Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi’an Jiao Tong University, Xi’an, Shaanxi Province, People’s Republic of China; 2Department of Ultrasound, The First Affiliated Hospital of Xi’an Jiao Tong...

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Autores principales:	Luan H, Song Y, Cao L, Wang P, Zhu D, Tian G
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	normal body mass index waist circumference coronary artery disease severe cad one-year re-admission with adverse cardiovascular event Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/6ab3ddcc3a84405899de491f7258ffb7
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spelling	oai:doaj.org-article:6ab3ddcc3a84405899de491f7258ffb72021-12-02T15:31:09ZGender Differences in the Relationship of Waist Circumference to Coronary Artery Lesions and One-Year Re-Admission Among Coronary Artery Disease Patients with Normal Body Mass Index1178-7007https://doaj.org/article/6ab3ddcc3a84405899de491f7258ffb72021-09-01T00:00:00Zhttps://www.dovepress.com/gender-differences-in-the-relationship-of-waist-circumference-to-coron-peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Hui Luan,1 Yan Song,2 Lifei Cao,1 Ping Wang,1 Danjun Zhu,1 Gang Tian1 1Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi’an Jiao Tong University, Xi’an, Shaanxi Province, People’s Republic of China; 2Department of Ultrasound, The First Affiliated Hospital of Xi’an Jiao Tong University, Xi’an, Shaanxi Province, People’s Republic of ChinaCorrespondence: Gang TianDepartment of Cardiovascular Medicine, The First Affiliated Hospital of Xi’an Jiao Tong University, No. 277 Yenta West Road, Xi’an, Shaanxi Province, 710061, People’s Republic of ChinaTel +86 29-85323112Fax +86 29-85252580Email tiangang@xjtu.edu.cnPurpose: The study explored the association of waist circumference (WC) with the severity of cardiovascular diseases and hospital readmission of coronary artery disease (CAD) patients with normal body mass index (BMI).Patients and Methods: 213 female and 431 male normal-BMI CAD patients were enrolled and assigned in three groups based on their gender-specific WC tertiles. Their cardiovascular risk factors and coronary angiography characteristics were analyzed in a cross-sectional study, and the gender-specific relationship between WC and one-year re-admission rate was prospectively explored.Results: The cross-sectional analysis showed that for male normal-BMI CAD patients, diabetes and dyslipidemia prevalence, Apo B/A1, hs-CRP, and uric acid levels triglycerides-glucose index, the incidence of left main disease, three vessel disease, calcification lesion, total occlusive lesion, and complex lesion, as well as Gensini score was in the order of WC tertile 3 > WC tertile 2 > WC tertile 1. In addition, male normal-BMI CAD patients in the highest WC tertile were at an increased risk of severe CAD (OR=2.21), and the correlation was still statistically significant even after adjusting for potential cardiovascular risk factors (OR=1.87). For female normal-BMI CAD patients, as the WC tertiles increased, uric acid level, the prevalence of three vessel disease, diffuse lesion, and complex lesion gradually increased (P < 0.05), but no significant difference was found in the risk of severe CAD among different WC groups (all P > 0.05). Prospective analyses showed that the higher the WC tertile was, the higher the one-year re-admission rate in men, but not in women, and after adjusting for other risk factors, men with the highest WC tertile showed more than twice the risk of patients with the lowest WC tertile.Conclusion: Male but not female, normal-BMI CAD patients with increased WC had more severe CAD and a higher risk of one-year re-admission rate.Keywords: normal body mass index, waist circumference, coronary artery disease, severe CAD, one-year re-admission with adverse cardiovascular eventLuan HSong YCao LWang PZhu DTian GDove Medical Pressarticlenormal body mass indexwaist circumferencecoronary artery diseasesevere cadone-year re-admission with adverse cardiovascular eventSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 4097-4107 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	normal body mass index waist circumference coronary artery disease severe cad one-year re-admission with adverse cardiovascular event Specialties of internal medicine RC581-951
spellingShingle	normal body mass index waist circumference coronary artery disease severe cad one-year re-admission with adverse cardiovascular event Specialties of internal medicine RC581-951 Luan H Song Y Cao L Wang P Zhu D Tian G Gender Differences in the Relationship of Waist Circumference to Coronary Artery Lesions and One-Year Re-Admission Among Coronary Artery Disease Patients with Normal Body Mass Index
description	Hui Luan,1 Yan Song,2 Lifei Cao,1 Ping Wang,1 Danjun Zhu,1 Gang Tian1 1Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi’an Jiao Tong University, Xi’an, Shaanxi Province, People’s Republic of China; 2Department of Ultrasound, The First Affiliated Hospital of Xi’an Jiao Tong University, Xi’an, Shaanxi Province, People’s Republic of ChinaCorrespondence: Gang TianDepartment of Cardiovascular Medicine, The First Affiliated Hospital of Xi’an Jiao Tong University, No. 277 Yenta West Road, Xi’an, Shaanxi Province, 710061, People’s Republic of ChinaTel +86 29-85323112Fax +86 29-85252580Email tiangang@xjtu.edu.cnPurpose: The study explored the association of waist circumference (WC) with the severity of cardiovascular diseases and hospital readmission of coronary artery disease (CAD) patients with normal body mass index (BMI).Patients and Methods: 213 female and 431 male normal-BMI CAD patients were enrolled and assigned in three groups based on their gender-specific WC tertiles. Their cardiovascular risk factors and coronary angiography characteristics were analyzed in a cross-sectional study, and the gender-specific relationship between WC and one-year re-admission rate was prospectively explored.Results: The cross-sectional analysis showed that for male normal-BMI CAD patients, diabetes and dyslipidemia prevalence, Apo B/A1, hs-CRP, and uric acid levels triglycerides-glucose index, the incidence of left main disease, three vessel disease, calcification lesion, total occlusive lesion, and complex lesion, as well as Gensini score was in the order of WC tertile 3 > WC tertile 2 > WC tertile 1. In addition, male normal-BMI CAD patients in the highest WC tertile were at an increased risk of severe CAD (OR=2.21), and the correlation was still statistically significant even after adjusting for potential cardiovascular risk factors (OR=1.87). For female normal-BMI CAD patients, as the WC tertiles increased, uric acid level, the prevalence of three vessel disease, diffuse lesion, and complex lesion gradually increased (P < 0.05), but no significant difference was found in the risk of severe CAD among different WC groups (all P > 0.05). Prospective analyses showed that the higher the WC tertile was, the higher the one-year re-admission rate in men, but not in women, and after adjusting for other risk factors, men with the highest WC tertile showed more than twice the risk of patients with the lowest WC tertile.Conclusion: Male but not female, normal-BMI CAD patients with increased WC had more severe CAD and a higher risk of one-year re-admission rate.Keywords: normal body mass index, waist circumference, coronary artery disease, severe CAD, one-year re-admission with adverse cardiovascular event
format	article
author	Luan H Song Y Cao L Wang P Zhu D Tian G
author_facet	Luan H Song Y Cao L Wang P Zhu D Tian G
author_sort	Luan H
title	Gender Differences in the Relationship of Waist Circumference to Coronary Artery Lesions and One-Year Re-Admission Among Coronary Artery Disease Patients with Normal Body Mass Index
title_short	Gender Differences in the Relationship of Waist Circumference to Coronary Artery Lesions and One-Year Re-Admission Among Coronary Artery Disease Patients with Normal Body Mass Index
title_full	Gender Differences in the Relationship of Waist Circumference to Coronary Artery Lesions and One-Year Re-Admission Among Coronary Artery Disease Patients with Normal Body Mass Index
title_fullStr	Gender Differences in the Relationship of Waist Circumference to Coronary Artery Lesions and One-Year Re-Admission Among Coronary Artery Disease Patients with Normal Body Mass Index
title_full_unstemmed	Gender Differences in the Relationship of Waist Circumference to Coronary Artery Lesions and One-Year Re-Admission Among Coronary Artery Disease Patients with Normal Body Mass Index
title_sort	gender differences in the relationship of waist circumference to coronary artery lesions and one-year re-admission among coronary artery disease patients with normal body mass index
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/6ab3ddcc3a84405899de491f7258ffb7
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Gender Differences in the Relationship of Waist Circumference to Coronary Artery Lesions and One-Year Re-Admission Among Coronary Artery Disease Patients with Normal Body Mass Index

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