The Interplay of Vitamin D Deficiency and Cellular Senescence in The Pathogenesis of Obesity-Related Co-Morbidities

This scoping review aims to clarify the interplay between obesity, vitamin D deficiency, cellular senescence, and obesity-related metabolic consequences, mainly subclinical atherosclerosis, and non-alcoholic fatty liver disease (NAFLD). Obesity is a significant global health problem that involves ce...

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Autores principales:	Abdulhadi Bima, Basmah Eldakhakhny, Dina Nuwaylati, Abrar Alnami, Mohammed Ajabnoor, Ayman Elsamanoudy
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	vitamin D deficiency cellular senescence obesity non-alcoholic fatty liver disease subclinical atherosclerosis Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/6ab5d62a2b824d88ae0fc72b8f06426f
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spelling	oai:doaj.org-article:6ab5d62a2b824d88ae0fc72b8f06426f2021-11-25T18:36:58ZThe Interplay of Vitamin D Deficiency and Cellular Senescence in The Pathogenesis of Obesity-Related Co-Morbidities10.3390/nu131141272072-6643https://doaj.org/article/6ab5d62a2b824d88ae0fc72b8f06426f2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4127https://doaj.org/toc/2072-6643This scoping review aims to clarify the interplay between obesity, vitamin D deficiency, cellular senescence, and obesity-related metabolic consequences, mainly subclinical atherosclerosis, and non-alcoholic fatty liver disease (NAFLD). Obesity is a significant global health problem that involves cellular, environmental, behavioral, and genetic elements. The fundamental cause of obesity throughout all life stages is an energy imbalance, and its consequences are countless and, foremost, very common. Obesity has been comprehensively studied in the literature given its association with low serum vitamin D, with many proposed mechanisms linking the two conditions. Moreover, markers of exaggerated cellular senescence have been proven to accumulate in obese individuals. Subclinical atherosclerosis initiates an early stage that ends in serious cardiac events, and obesity, low vitamin D, and senescent cells largely contribute to its associated chronic low-grade inflammation. Furthermore, NAFLD signifies the hepatic manifestation of metabolic syndrome, and studies have highlighted the important role of obesity, vitamin D deficiency, and cellular senescence in its development. Therefore, we outlined the most important mechanisms tying these conditions to one another.Abdulhadi BimaBasmah EldakhakhnyDina NuwaylatiAbrar AlnamiMohammed AjabnoorAyman ElsamanoudyMDPI AGarticlevitamin D deficiencycellular senescenceobesitynon-alcoholic fatty liver diseasesubclinical atherosclerosisNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4127, p 4127 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	vitamin D deficiency cellular senescence obesity non-alcoholic fatty liver disease subclinical atherosclerosis Nutrition. Foods and food supply TX341-641
spellingShingle	vitamin D deficiency cellular senescence obesity non-alcoholic fatty liver disease subclinical atherosclerosis Nutrition. Foods and food supply TX341-641 Abdulhadi Bima Basmah Eldakhakhny Dina Nuwaylati Abrar Alnami Mohammed Ajabnoor Ayman Elsamanoudy The Interplay of Vitamin D Deficiency and Cellular Senescence in The Pathogenesis of Obesity-Related Co-Morbidities
description	This scoping review aims to clarify the interplay between obesity, vitamin D deficiency, cellular senescence, and obesity-related metabolic consequences, mainly subclinical atherosclerosis, and non-alcoholic fatty liver disease (NAFLD). Obesity is a significant global health problem that involves cellular, environmental, behavioral, and genetic elements. The fundamental cause of obesity throughout all life stages is an energy imbalance, and its consequences are countless and, foremost, very common. Obesity has been comprehensively studied in the literature given its association with low serum vitamin D, with many proposed mechanisms linking the two conditions. Moreover, markers of exaggerated cellular senescence have been proven to accumulate in obese individuals. Subclinical atherosclerosis initiates an early stage that ends in serious cardiac events, and obesity, low vitamin D, and senescent cells largely contribute to its associated chronic low-grade inflammation. Furthermore, NAFLD signifies the hepatic manifestation of metabolic syndrome, and studies have highlighted the important role of obesity, vitamin D deficiency, and cellular senescence in its development. Therefore, we outlined the most important mechanisms tying these conditions to one another.
format	article
author	Abdulhadi Bima Basmah Eldakhakhny Dina Nuwaylati Abrar Alnami Mohammed Ajabnoor Ayman Elsamanoudy
author_facet	Abdulhadi Bima Basmah Eldakhakhny Dina Nuwaylati Abrar Alnami Mohammed Ajabnoor Ayman Elsamanoudy
author_sort	Abdulhadi Bima
title	The Interplay of Vitamin D Deficiency and Cellular Senescence in The Pathogenesis of Obesity-Related Co-Morbidities
title_short	The Interplay of Vitamin D Deficiency and Cellular Senescence in The Pathogenesis of Obesity-Related Co-Morbidities
title_full	The Interplay of Vitamin D Deficiency and Cellular Senescence in The Pathogenesis of Obesity-Related Co-Morbidities
title_fullStr	The Interplay of Vitamin D Deficiency and Cellular Senescence in The Pathogenesis of Obesity-Related Co-Morbidities
title_full_unstemmed	The Interplay of Vitamin D Deficiency and Cellular Senescence in The Pathogenesis of Obesity-Related Co-Morbidities
title_sort	interplay of vitamin d deficiency and cellular senescence in the pathogenesis of obesity-related co-morbidities
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6ab5d62a2b824d88ae0fc72b8f06426f
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The Interplay of Vitamin D Deficiency and Cellular Senescence in The Pathogenesis of Obesity-Related Co-Morbidities

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