Phytochemicals as an Alternative or Integrative Option, in Conjunction with Conventional Treatments for Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is the most abundant form of liver cancer. It accounts for 75–85% of liver cancer cases and, though it ranks globally as the sixth most common cancer, it ranks second in cancer-related mortality. Deaths from HCC are usually due to metastatic spread of the cancer. Unfor...

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Autores principales:	Sheryl Rodriguez, Kristy Skeet, Tugba Mehmetoglu-Gurbuz, Madeline Goldfarb, Shri Karri, Jackelyn Rocha, Mark Shahinian, Abdallah Yazadi, Seeta Poudel, Ramadevi Subramani
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	hepatocellular carcinoma liver cancer phytochemicals natural compounds metastasis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/6ab85bc24c7a4b04993217de6fed6120
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spelling	oai:doaj.org-article:6ab85bc24c7a4b04993217de6fed61202021-11-25T17:03:37ZPhytochemicals as an Alternative or Integrative Option, in Conjunction with Conventional Treatments for Hepatocellular Carcinoma10.3390/cancers132257532072-6694https://doaj.org/article/6ab85bc24c7a4b04993217de6fed61202021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5753https://doaj.org/toc/2072-6694Hepatocellular carcinoma (HCC) is the most abundant form of liver cancer. It accounts for 75–85% of liver cancer cases and, though it ranks globally as the sixth most common cancer, it ranks second in cancer-related mortality. Deaths from HCC are usually due to metastatic spread of the cancer. Unfortunately, there are many challenges and limitations with the latest HCC therapies and medications, making it difficult for patients to receive life-prolonging care. As there is clearly a high demand for alternative therapy options for HCC, it is prudent to turn to plants for the solution, as their phytochemicals have long been used and revered for their many medicinal purposes. This review explores the promising phytochemical compounds identified from pre-clinical and clinical trials being used either independently or in conjunction with already existing cancer therapy treatments. The phytochemicals discussed in this review were classified into several categories: lipids, polyphenols, alkaloids, polysaccharides, whole extracts, and phytochemical combinations. Almost 80% of the compounds failed to progress into clinical studies due to lack of information regarding the toxicity to normal cells and bioavailability. Although large obstacles remain, phytochemicals can be used either as an alternative or integrative therapy in conjunction with existing HCC chemotherapies. In conclusion, phytochemicals have great potential as treatment options for hepatocellular carcinoma.Sheryl RodriguezKristy SkeetTugba Mehmetoglu-GurbuzMadeline GoldfarbShri KarriJackelyn RochaMark ShahinianAbdallah YazadiSeeta PoudelRamadevi SubramaniMDPI AGarticlehepatocellular carcinomaliver cancerphytochemicalsnatural compoundsmetastasisNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5753, p 5753 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hepatocellular carcinoma liver cancer phytochemicals natural compounds metastasis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	hepatocellular carcinoma liver cancer phytochemicals natural compounds metastasis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Sheryl Rodriguez Kristy Skeet Tugba Mehmetoglu-Gurbuz Madeline Goldfarb Shri Karri Jackelyn Rocha Mark Shahinian Abdallah Yazadi Seeta Poudel Ramadevi Subramani Phytochemicals as an Alternative or Integrative Option, in Conjunction with Conventional Treatments for Hepatocellular Carcinoma
description	Hepatocellular carcinoma (HCC) is the most abundant form of liver cancer. It accounts for 75–85% of liver cancer cases and, though it ranks globally as the sixth most common cancer, it ranks second in cancer-related mortality. Deaths from HCC are usually due to metastatic spread of the cancer. Unfortunately, there are many challenges and limitations with the latest HCC therapies and medications, making it difficult for patients to receive life-prolonging care. As there is clearly a high demand for alternative therapy options for HCC, it is prudent to turn to plants for the solution, as their phytochemicals have long been used and revered for their many medicinal purposes. This review explores the promising phytochemical compounds identified from pre-clinical and clinical trials being used either independently or in conjunction with already existing cancer therapy treatments. The phytochemicals discussed in this review were classified into several categories: lipids, polyphenols, alkaloids, polysaccharides, whole extracts, and phytochemical combinations. Almost 80% of the compounds failed to progress into clinical studies due to lack of information regarding the toxicity to normal cells and bioavailability. Although large obstacles remain, phytochemicals can be used either as an alternative or integrative therapy in conjunction with existing HCC chemotherapies. In conclusion, phytochemicals have great potential as treatment options for hepatocellular carcinoma.
format	article
author	Sheryl Rodriguez Kristy Skeet Tugba Mehmetoglu-Gurbuz Madeline Goldfarb Shri Karri Jackelyn Rocha Mark Shahinian Abdallah Yazadi Seeta Poudel Ramadevi Subramani
author_facet	Sheryl Rodriguez Kristy Skeet Tugba Mehmetoglu-Gurbuz Madeline Goldfarb Shri Karri Jackelyn Rocha Mark Shahinian Abdallah Yazadi Seeta Poudel Ramadevi Subramani
author_sort	Sheryl Rodriguez
title	Phytochemicals as an Alternative or Integrative Option, in Conjunction with Conventional Treatments for Hepatocellular Carcinoma
title_short	Phytochemicals as an Alternative or Integrative Option, in Conjunction with Conventional Treatments for Hepatocellular Carcinoma
title_full	Phytochemicals as an Alternative or Integrative Option, in Conjunction with Conventional Treatments for Hepatocellular Carcinoma
title_fullStr	Phytochemicals as an Alternative or Integrative Option, in Conjunction with Conventional Treatments for Hepatocellular Carcinoma
title_full_unstemmed	Phytochemicals as an Alternative or Integrative Option, in Conjunction with Conventional Treatments for Hepatocellular Carcinoma
title_sort	phytochemicals as an alternative or integrative option, in conjunction with conventional treatments for hepatocellular carcinoma
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6ab85bc24c7a4b04993217de6fed6120
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Phytochemicals as an Alternative or Integrative Option, in Conjunction with Conventional Treatments for Hepatocellular Carcinoma

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