Role of circRNA-miRNA-mRNA interaction network in diabetes and its associated complications

The majority of the non-protein-coding RNAs are being identified with diversified functions that participate in cellular homeostasis. The circular RNAs (circRNAs) are emerging as noncoding transcripts with a key role in the initiation and development of many physiological and pathological conditions...

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Autores principales:	Shukla Sakshi, Ravichandran Jayasuriya, Kumar Ganesan, Baojun Xu, Kunka Mohanram Ramkumar
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	circRNA-miRNA-mRNA diabetes diabetic complications Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/6abb16675802431e9c563d31946a6550
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spelling	oai:doaj.org-article:6abb16675802431e9c563d31946a65502021-11-22T04:24:03ZRole of circRNA-miRNA-mRNA interaction network in diabetes and its associated complications2162-253110.1016/j.omtn.2021.11.007https://doaj.org/article/6abb16675802431e9c563d31946a65502021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2162253121002821https://doaj.org/toc/2162-2531The majority of the non-protein-coding RNAs are being identified with diversified functions that participate in cellular homeostasis. The circular RNAs (circRNAs) are emerging as noncoding transcripts with a key role in the initiation and development of many physiological and pathological conditions. The advancements in high-throughput RNA sequencing and bioinformatics tools help us to identify several circRNA regulatory pathways, one of which is microRNA (miRNA)-mediated regulation. Besides the direct influence over mRNA transcription, the circRNA can also control the target's expression via sponging miRNAs or the RNA-binding proteins. Studies have demonstrated the dysregulation of the circRNA-miRNA-mRNA interaction network in the pathogenesis of many diseases, including diabetes. This intricate mechanism is associated with the pathogenesis of diabetes and its complications. This review will focus on the circRNA-miRNA-mRNA interaction network that influences the gene expression in the progression of diabetes and its associated complications.Shukla SakshiRavichandran JayasuriyaKumar GanesanBaojun XuKunka Mohanram RamkumarElsevierarticlecircRNA-miRNA-mRNAdiabetesdiabetic complicationsTherapeutics. PharmacologyRM1-950ENMolecular Therapy: Nucleic Acids, Vol 26, Iss , Pp 1291-1302 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	circRNA-miRNA-mRNA diabetes diabetic complications Therapeutics. Pharmacology RM1-950
spellingShingle	circRNA-miRNA-mRNA diabetes diabetic complications Therapeutics. Pharmacology RM1-950 Shukla Sakshi Ravichandran Jayasuriya Kumar Ganesan Baojun Xu Kunka Mohanram Ramkumar Role of circRNA-miRNA-mRNA interaction network in diabetes and its associated complications
description	The majority of the non-protein-coding RNAs are being identified with diversified functions that participate in cellular homeostasis. The circular RNAs (circRNAs) are emerging as noncoding transcripts with a key role in the initiation and development of many physiological and pathological conditions. The advancements in high-throughput RNA sequencing and bioinformatics tools help us to identify several circRNA regulatory pathways, one of which is microRNA (miRNA)-mediated regulation. Besides the direct influence over mRNA transcription, the circRNA can also control the target's expression via sponging miRNAs or the RNA-binding proteins. Studies have demonstrated the dysregulation of the circRNA-miRNA-mRNA interaction network in the pathogenesis of many diseases, including diabetes. This intricate mechanism is associated with the pathogenesis of diabetes and its complications. This review will focus on the circRNA-miRNA-mRNA interaction network that influences the gene expression in the progression of diabetes and its associated complications.
format	article
author	Shukla Sakshi Ravichandran Jayasuriya Kumar Ganesan Baojun Xu Kunka Mohanram Ramkumar
author_facet	Shukla Sakshi Ravichandran Jayasuriya Kumar Ganesan Baojun Xu Kunka Mohanram Ramkumar
author_sort	Shukla Sakshi
title	Role of circRNA-miRNA-mRNA interaction network in diabetes and its associated complications
title_short	Role of circRNA-miRNA-mRNA interaction network in diabetes and its associated complications
title_full	Role of circRNA-miRNA-mRNA interaction network in diabetes and its associated complications
title_fullStr	Role of circRNA-miRNA-mRNA interaction network in diabetes and its associated complications
title_full_unstemmed	Role of circRNA-miRNA-mRNA interaction network in diabetes and its associated complications
title_sort	role of circrna-mirna-mrna interaction network in diabetes and its associated complications
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/6abb16675802431e9c563d31946a6550
work_keys_str_mv	AT shuklasakshi roleofcircrnamirnamrnainteractionnetworkindiabetesanditsassociatedcomplications AT ravichandranjayasuriya roleofcircrnamirnamrnainteractionnetworkindiabetesanditsassociatedcomplications AT kumarganesan roleofcircrnamirnamrnainteractionnetworkindiabetesanditsassociatedcomplications AT baojunxu roleofcircrnamirnamrnainteractionnetworkindiabetesanditsassociatedcomplications AT kunkamohanramramkumar roleofcircrnamirnamrnainteractionnetworkindiabetesanditsassociatedcomplications
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Role of circRNA-miRNA-mRNA interaction network in diabetes and its associated complications

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