Resection of isolated brain metastases in non-small cell lung cancer (NSCLC) patients - evaluation of outcome and prognostic factors: A retrospective multicenter study.

<h4>Background and objectives</h4>Brain metastases occur in about 30% of all patients with non-small cell lung cancer (NSCLC). In selected patients, long-term survival can be achieved by resection of brain metastases. In this retrospective study, we investigate the prognosis of NSCLC pat...

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Autores principales:	Julia Fuchs, Martin Früh, Alexandros Papachristofilou, Lukas Bubendorf, Pirmin Häuptle, Lorenz Jost, Alfred Zippelius, Sacha I Rothschild
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6abb801311694a088ca7d82c15adf901
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spelling	oai:doaj.org-article:6abb801311694a088ca7d82c15adf9012021-12-02T20:09:54ZResection of isolated brain metastases in non-small cell lung cancer (NSCLC) patients - evaluation of outcome and prognostic factors: A retrospective multicenter study.1932-620310.1371/journal.pone.0253601https://doaj.org/article/6abb801311694a088ca7d82c15adf9012021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253601https://doaj.org/toc/1932-6203<h4>Background and objectives</h4>Brain metastases occur in about 30% of all patients with non-small cell lung cancer (NSCLC). In selected patients, long-term survival can be achieved by resection of brain metastases. In this retrospective study, we investigate the prognosis of NSCLC patients with resected brain metastases and possible prognostic factors.<h4>Methods</h4>In 119 patients with NSCLC and resected brain metastases, we report the following parameters: extent of resection, resection status, postoperative complications and overall survival (OS). We used the log-rank test to compare unadjusted survival probabilities and multivariable Cox regression to investigate potential prognostic factors with respect to OS.<h4>Results</h4>A total of 146 brain metastases were resected in 119 patients. The median survival was 18.0 months. Postoperative cerebral radiotherapy was performed in 86% of patients. Patients with postoperative radiotherapy had significantly longer survival (median OS 20.2 vs. 9.0 months, p = 0.002). The presence of multiple brain metastases was a negative prognostic factor (median OS 13.5 vs. 19.5 months, p = 0.006). Survival of patients with extracerebral metastases of NSCLC was significantly shorter than in patients who had exclusively brain metastases (median OS 14.0 vs. 23.1 months, p = 0.005). Both of the latter factors were independent prognostic factors for worse outcome in multivariate analysis.<h4>Conclusions</h4>Based on these data, resection of solitary brain metastases in patients with NSCLC and controlled extracerebral tumor disease is safe and leads to an overall favorable outcome. Postoperative radiotherapy is recommended to improve prognosis.Julia FuchsMartin FrühAlexandros PapachristofilouLukas BubendorfPirmin HäuptleLorenz JostAlfred ZippeliusSacha I RothschildPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0253601 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Julia Fuchs Martin Früh Alexandros Papachristofilou Lukas Bubendorf Pirmin Häuptle Lorenz Jost Alfred Zippelius Sacha I Rothschild Resection of isolated brain metastases in non-small cell lung cancer (NSCLC) patients - evaluation of outcome and prognostic factors: A retrospective multicenter study.
description	<h4>Background and objectives</h4>Brain metastases occur in about 30% of all patients with non-small cell lung cancer (NSCLC). In selected patients, long-term survival can be achieved by resection of brain metastases. In this retrospective study, we investigate the prognosis of NSCLC patients with resected brain metastases and possible prognostic factors.<h4>Methods</h4>In 119 patients with NSCLC and resected brain metastases, we report the following parameters: extent of resection, resection status, postoperative complications and overall survival (OS). We used the log-rank test to compare unadjusted survival probabilities and multivariable Cox regression to investigate potential prognostic factors with respect to OS.<h4>Results</h4>A total of 146 brain metastases were resected in 119 patients. The median survival was 18.0 months. Postoperative cerebral radiotherapy was performed in 86% of patients. Patients with postoperative radiotherapy had significantly longer survival (median OS 20.2 vs. 9.0 months, p = 0.002). The presence of multiple brain metastases was a negative prognostic factor (median OS 13.5 vs. 19.5 months, p = 0.006). Survival of patients with extracerebral metastases of NSCLC was significantly shorter than in patients who had exclusively brain metastases (median OS 14.0 vs. 23.1 months, p = 0.005). Both of the latter factors were independent prognostic factors for worse outcome in multivariate analysis.<h4>Conclusions</h4>Based on these data, resection of solitary brain metastases in patients with NSCLC and controlled extracerebral tumor disease is safe and leads to an overall favorable outcome. Postoperative radiotherapy is recommended to improve prognosis.
format	article
author	Julia Fuchs Martin Früh Alexandros Papachristofilou Lukas Bubendorf Pirmin Häuptle Lorenz Jost Alfred Zippelius Sacha I Rothschild
author_facet	Julia Fuchs Martin Früh Alexandros Papachristofilou Lukas Bubendorf Pirmin Häuptle Lorenz Jost Alfred Zippelius Sacha I Rothschild
author_sort	Julia Fuchs
title	Resection of isolated brain metastases in non-small cell lung cancer (NSCLC) patients - evaluation of outcome and prognostic factors: A retrospective multicenter study.
title_short	Resection of isolated brain metastases in non-small cell lung cancer (NSCLC) patients - evaluation of outcome and prognostic factors: A retrospective multicenter study.
title_full	Resection of isolated brain metastases in non-small cell lung cancer (NSCLC) patients - evaluation of outcome and prognostic factors: A retrospective multicenter study.
title_fullStr	Resection of isolated brain metastases in non-small cell lung cancer (NSCLC) patients - evaluation of outcome and prognostic factors: A retrospective multicenter study.
title_full_unstemmed	Resection of isolated brain metastases in non-small cell lung cancer (NSCLC) patients - evaluation of outcome and prognostic factors: A retrospective multicenter study.
title_sort	resection of isolated brain metastases in non-small cell lung cancer (nsclc) patients - evaluation of outcome and prognostic factors: a retrospective multicenter study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/6abb801311694a088ca7d82c15adf901
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Resection of isolated brain metastases in non-small cell lung cancer (NSCLC) patients - evaluation of outcome and prognostic factors: A retrospective multicenter study.

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