Biological Rationale and Clinical Evidence of Carbon Ion Radiation Therapy for Adenoid Cystic Carcinoma: A Narrative Review

Adenoid cystic carcinoma (ACC) is a rare, basaloid, epithelial tumor, arising mostly from salivary glands. Radiation therapy can be employed as a single modality for unresectable tumors, in an adjuvant setting after uncomplete resection, in case of high-risk pathological features, or for recurrent t...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Pierre Loap, Barbara Vischioni, Maria Bonora, Rossana Ingargiola, Sara Ronchi, Viviana Vitolo, Amelia Barcellini, Lucia Goanta, Ludovic De Marzi, Remi Dendale, Roberto Pacelli, Laura Locati, Valentin Calugaru, Hamid Mammar, Stefano Cavalieri, Youlia Kirova, Ester Orlandi
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	adenoid cyst carcinoma hadrontherapy carbon ion radiotherapy (CIRT) tumor immunology radioresistance Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/6abf9a0c59344ab7b3ad937177ddf0f3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6abf9a0c59344ab7b3ad937177ddf0f3
record_format	dspace
spelling	oai:doaj.org-article:6abf9a0c59344ab7b3ad937177ddf0f32021-12-01T15:09:46ZBiological Rationale and Clinical Evidence of Carbon Ion Radiation Therapy for Adenoid Cystic Carcinoma: A Narrative Review2234-943X10.3389/fonc.2021.789079https://doaj.org/article/6abf9a0c59344ab7b3ad937177ddf0f32021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.789079/fullhttps://doaj.org/toc/2234-943XAdenoid cystic carcinoma (ACC) is a rare, basaloid, epithelial tumor, arising mostly from salivary glands. Radiation therapy can be employed as a single modality for unresectable tumors, in an adjuvant setting after uncomplete resection, in case of high-risk pathological features, or for recurrent tumors. Due to ACC intrinsic radioresistance, high linear energy transfer (LET) radiotherapy techniques have been evaluated for ACC irradiation: while fast neutron therapy has now been abandoned due to toxicity concerns, charged particle beams such as protons and carbon ions are at present the beams used for hadron therapy. Carbon ion radiation therapy (CIRT) is currently increasingly used for ACC irradiation. The aim of this review is to describe the immunological, molecular and clinicopathological bases that support ACC treatment with CIRT, as well as to expose the current clinical evidence that reveal the advantages of using CIRT for treating ACC.Pierre LoapPierre LoapPierre LoapBarbara VischioniMaria BonoraRossana IngargiolaSara RonchiViviana VitoloAmelia BarcelliniLucia GoantaLudovic De MarziLudovic De MarziLudovic De MarziRemi DendaleRemi DendaleRoberto PacelliLaura LocatiLaura LocatiValentin CalugaruValentin CalugaruHamid MammarHamid MammarStefano CavalieriStefano CavalieriYoulia KirovaYoulia KirovaEster OrlandiFrontiers Media S.A.articleadenoid cyst carcinomahadrontherapycarbon ion radiotherapy (CIRT)tumor immunologyradioresistanceNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	adenoid cyst carcinoma hadrontherapy carbon ion radiotherapy (CIRT) tumor immunology radioresistance Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	adenoid cyst carcinoma hadrontherapy carbon ion radiotherapy (CIRT) tumor immunology radioresistance Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Pierre Loap Pierre Loap Pierre Loap Barbara Vischioni Maria Bonora Rossana Ingargiola Sara Ronchi Viviana Vitolo Amelia Barcellini Lucia Goanta Ludovic De Marzi Ludovic De Marzi Ludovic De Marzi Remi Dendale Remi Dendale Roberto Pacelli Laura Locati Laura Locati Valentin Calugaru Valentin Calugaru Hamid Mammar Hamid Mammar Stefano Cavalieri Stefano Cavalieri Youlia Kirova Youlia Kirova Ester Orlandi Biological Rationale and Clinical Evidence of Carbon Ion Radiation Therapy for Adenoid Cystic Carcinoma: A Narrative Review
description	Adenoid cystic carcinoma (ACC) is a rare, basaloid, epithelial tumor, arising mostly from salivary glands. Radiation therapy can be employed as a single modality for unresectable tumors, in an adjuvant setting after uncomplete resection, in case of high-risk pathological features, or for recurrent tumors. Due to ACC intrinsic radioresistance, high linear energy transfer (LET) radiotherapy techniques have been evaluated for ACC irradiation: while fast neutron therapy has now been abandoned due to toxicity concerns, charged particle beams such as protons and carbon ions are at present the beams used for hadron therapy. Carbon ion radiation therapy (CIRT) is currently increasingly used for ACC irradiation. The aim of this review is to describe the immunological, molecular and clinicopathological bases that support ACC treatment with CIRT, as well as to expose the current clinical evidence that reveal the advantages of using CIRT for treating ACC.
format	article
author	Pierre Loap Pierre Loap Pierre Loap Barbara Vischioni Maria Bonora Rossana Ingargiola Sara Ronchi Viviana Vitolo Amelia Barcellini Lucia Goanta Ludovic De Marzi Ludovic De Marzi Ludovic De Marzi Remi Dendale Remi Dendale Roberto Pacelli Laura Locati Laura Locati Valentin Calugaru Valentin Calugaru Hamid Mammar Hamid Mammar Stefano Cavalieri Stefano Cavalieri Youlia Kirova Youlia Kirova Ester Orlandi
author_facet	Pierre Loap Pierre Loap Pierre Loap Barbara Vischioni Maria Bonora Rossana Ingargiola Sara Ronchi Viviana Vitolo Amelia Barcellini Lucia Goanta Ludovic De Marzi Ludovic De Marzi Ludovic De Marzi Remi Dendale Remi Dendale Roberto Pacelli Laura Locati Laura Locati Valentin Calugaru Valentin Calugaru Hamid Mammar Hamid Mammar Stefano Cavalieri Stefano Cavalieri Youlia Kirova Youlia Kirova Ester Orlandi
author_sort	Pierre Loap
title	Biological Rationale and Clinical Evidence of Carbon Ion Radiation Therapy for Adenoid Cystic Carcinoma: A Narrative Review
title_short	Biological Rationale and Clinical Evidence of Carbon Ion Radiation Therapy for Adenoid Cystic Carcinoma: A Narrative Review
title_full	Biological Rationale and Clinical Evidence of Carbon Ion Radiation Therapy for Adenoid Cystic Carcinoma: A Narrative Review
title_fullStr	Biological Rationale and Clinical Evidence of Carbon Ion Radiation Therapy for Adenoid Cystic Carcinoma: A Narrative Review
title_full_unstemmed	Biological Rationale and Clinical Evidence of Carbon Ion Radiation Therapy for Adenoid Cystic Carcinoma: A Narrative Review
title_sort	biological rationale and clinical evidence of carbon ion radiation therapy for adenoid cystic carcinoma: a narrative review
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/6abf9a0c59344ab7b3ad937177ddf0f3
work_keys_str_mv	AT pierreloap biologicalrationaleandclinicalevidenceofcarbonionradiationtherapyforadenoidcysticcarcinomaanarrativereview AT pierreloap biologicalrationaleandclinicalevidenceofcarbonionradiationtherapyforadenoidcysticcarcinomaanarrativereview AT pierreloap biologicalrationaleandclinicalevidenceofcarbonionradiationtherapyforadenoidcysticcarcinomaanarrativereview AT barbaravischioni biologicalrationaleandclinicalevidenceofcarbonionradiationtherapyforadenoidcysticcarcinomaanarrativereview AT mariabonora biologicalrationaleandclinicalevidenceofcarbonionradiationtherapyforadenoidcysticcarcinomaanarrativereview AT rossanaingargiola biologicalrationaleandclinicalevidenceofcarbonionradiationtherapyforadenoidcysticcarcinomaanarrativereview AT sararonchi biologicalrationaleandclinicalevidenceofcarbonionradiationtherapyforadenoidcysticcarcinomaanarrativereview AT vivianavitolo biologicalrationaleandclinicalevidenceofcarbonionradiationtherapyforadenoidcysticcarcinomaanarrativereview AT ameliabarcellini biologicalrationaleandclinicalevidenceofcarbonionradiationtherapyforadenoidcysticcarcinomaanarrativereview AT luciagoanta biologicalrationaleandclinicalevidenceofcarbonionradiationtherapyforadenoidcysticcarcinomaanarrativereview AT ludovicdemarzi biologicalrationaleandclinicalevidenceofcarbonionradiationtherapyforadenoidcysticcarcinomaanarrativereview AT ludovicdemarzi biologicalrationaleandclinicalevidenceofcarbonionradiationtherapyforadenoidcysticcarcinomaanarrativereview AT ludovicdemarzi biologicalrationaleandclinicalevidenceofcarbonionradiationtherapyforadenoidcysticcarcinomaanarrativereview AT remidendale biologicalrationaleandclinicalevidenceofcarbonionradiationtherapyforadenoidcysticcarcinomaanarrativereview AT remidendale biologicalrationaleandclinicalevidenceofcarbonionradiationtherapyforadenoidcysticcarcinomaanarrativereview AT robertopacelli biologicalrationaleandclinicalevidenceofcarbonionradiationtherapyforadenoidcysticcarcinomaanarrativereview AT lauralocati biologicalrationaleandclinicalevidenceofcarbonionradiationtherapyforadenoidcysticcarcinomaanarrativereview AT lauralocati biologicalrationaleandclinicalevidenceofcarbonionradiationtherapyforadenoidcysticcarcinomaanarrativereview AT valentincalugaru biologicalrationaleandclinicalevidenceofcarbonionradiationtherapyforadenoidcysticcarcinomaanarrativereview AT valentincalugaru biologicalrationaleandclinicalevidenceofcarbonionradiationtherapyforadenoidcysticcarcinomaanarrativereview AT hamidmammar biologicalrationaleandclinicalevidenceofcarbonionradiationtherapyforadenoidcysticcarcinomaanarrativereview AT hamidmammar biologicalrationaleandclinicalevidenceofcarbonionradiationtherapyforadenoidcysticcarcinomaanarrativereview AT stefanocavalieri biologicalrationaleandclinicalevidenceofcarbonionradiationtherapyforadenoidcysticcarcinomaanarrativereview AT stefanocavalieri biologicalrationaleandclinicalevidenceofcarbonionradiationtherapyforadenoidcysticcarcinomaanarrativereview AT youliakirova biologicalrationaleandclinicalevidenceofcarbonionradiationtherapyforadenoidcysticcarcinomaanarrativereview AT youliakirova biologicalrationaleandclinicalevidenceofcarbonionradiationtherapyforadenoidcysticcarcinomaanarrativereview AT esterorlandi biologicalrationaleandclinicalevidenceofcarbonionradiationtherapyforadenoidcysticcarcinomaanarrativereview
_version_	1718404875764629504

Biological Rationale and Clinical Evidence of Carbon Ion Radiation Therapy for Adenoid Cystic Carcinoma: A Narrative Review

Ejemplares similares