Honey bee Royalactin unlocks conserved pluripotency pathway in mammals

Honey bee Royalactin unlocks conserved pluripotency pathway in mammals

Royal jelly is the queen-maker for the honey bee that also has effects on longevity, fertility, and regeneration in mammals. Here the authors provide evidence that its major protein component Royalactin, and the mammalian structural analog Regina, maintain pluripotency in mouse ESCs by activating a...

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Autores principales: Derrick C. Wan, Stefanie L. Morgan, Andrew L. Spencley, Natasha Mariano, Erin Y. Chang, Gautam Shankar, Yunhai Luo, Ted H. Li, Dana Huh, Star K. Huynh, Jasmine M. Garcia, Cole M. Dovey, Jennifer Lumb, Ling Liu, Katharine V. Brown, Abel Bermudez, Richard Luong, Hong Zeng, Victoria L. Mascetti, Sharon J. Pitteri, Jordon Wang, Hua Tu, Marco Quarta, Vittorio Sebastiano, Roel Nusse, Thomas A. Rando, Jan E. Carette, J. Fernando Bazan, Kevin C. Wang
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Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/6ac458ba736146368698999f73b60666
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spelling oai:doaj.org-article:6ac458ba736146368698999f73b606662021-12-02T17:33:15ZHoney bee Royalactin unlocks conserved pluripotency pathway in mammals10.1038/s41467-018-06256-42041-1723https://doaj.org/article/6ac458ba736146368698999f73b606662018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06256-4https://doaj.org/toc/2041-1723Royal jelly is the queen-maker for the honey bee that also has effects on longevity, fertility, and regeneration in mammals. Here the authors provide evidence that its major protein component Royalactin, and the mammalian structural analog Regina, maintain pluripotency in mouse ESCs by activating a ground-state pluripotency-like gene network.Derrick C. WanStefanie L. MorganAndrew L. SpencleyNatasha MarianoErin Y. ChangGautam ShankarYunhai LuoTed H. LiDana HuhStar K. HuynhJasmine M. GarciaCole M. DoveyJennifer LumbLing LiuKatharine V. BrownAbel BermudezRichard LuongHong ZengVictoria L. MascettiSharon J. PitteriJordon WangHua TuMarco QuartaVittorio SebastianoRoel NusseThomas A. RandoJan E. CaretteJ. Fernando BazanKevin C. WangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Derrick C. Wan
Stefanie L. Morgan
Andrew L. Spencley
Natasha Mariano
Erin Y. Chang
Gautam Shankar
Yunhai Luo
Ted H. Li
Dana Huh
Star K. Huynh
Jasmine M. Garcia
Cole M. Dovey
Jennifer Lumb
Ling Liu
Katharine V. Brown
Abel Bermudez
Richard Luong
Hong Zeng
Victoria L. Mascetti
Sharon J. Pitteri
Jordon Wang
Hua Tu
Marco Quarta
Vittorio Sebastiano
Roel Nusse
Thomas A. Rando
Jan E. Carette
J. Fernando Bazan
Kevin C. Wang
Honey bee Royalactin unlocks conserved pluripotency pathway in mammals
description Royal jelly is the queen-maker for the honey bee that also has effects on longevity, fertility, and regeneration in mammals. Here the authors provide evidence that its major protein component Royalactin, and the mammalian structural analog Regina, maintain pluripotency in mouse ESCs by activating a ground-state pluripotency-like gene network.
format article
author Derrick C. Wan
Stefanie L. Morgan
Andrew L. Spencley
Natasha Mariano
Erin Y. Chang
Gautam Shankar
Yunhai Luo
Ted H. Li
Dana Huh
Star K. Huynh
Jasmine M. Garcia
Cole M. Dovey
Jennifer Lumb
Ling Liu
Katharine V. Brown
Abel Bermudez
Richard Luong
Hong Zeng
Victoria L. Mascetti
Sharon J. Pitteri
Jordon Wang
Hua Tu
Marco Quarta
Vittorio Sebastiano
Roel Nusse
Thomas A. Rando
Jan E. Carette
J. Fernando Bazan
Kevin C. Wang
author_facet Derrick C. Wan
Stefanie L. Morgan
Andrew L. Spencley
Natasha Mariano
Erin Y. Chang
Gautam Shankar
Yunhai Luo
Ted H. Li
Dana Huh
Star K. Huynh
Jasmine M. Garcia
Cole M. Dovey
Jennifer Lumb
Ling Liu
Katharine V. Brown
Abel Bermudez
Richard Luong
Hong Zeng
Victoria L. Mascetti
Sharon J. Pitteri
Jordon Wang
Hua Tu
Marco Quarta
Vittorio Sebastiano
Roel Nusse
Thomas A. Rando
Jan E. Carette
J. Fernando Bazan
Kevin C. Wang
author_sort Derrick C. Wan
title Honey bee Royalactin unlocks conserved pluripotency pathway in mammals
title_short Honey bee Royalactin unlocks conserved pluripotency pathway in mammals
title_full Honey bee Royalactin unlocks conserved pluripotency pathway in mammals
title_fullStr Honey bee Royalactin unlocks conserved pluripotency pathway in mammals
title_full_unstemmed Honey bee Royalactin unlocks conserved pluripotency pathway in mammals
title_sort honey bee royalactin unlocks conserved pluripotency pathway in mammals
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/6ac458ba736146368698999f73b60666
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