Fibrotic microtissue array to predict anti-fibrosis drug efficacy

A bottleneck in developing new anti-fibrosis therapies is the absence of suitable in vitro models that recapitulate key features of fibrogenesis. Here the authors develop a tissue-on-a-chip model of lung fibrosis and test the therapeutic efficacy of two recent FDA-approved drugs.

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Autores principales:	Mohammadnabi Asmani, Sanjana Velumani, Yan Li, Nicole Wawrzyniak, Isaac Hsia, Zhaowei Chen, Boris Hinz, Ruogang Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6ac76a78833f45c899ebfb821c22460e
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spelling	oai:doaj.org-article:6ac76a78833f45c899ebfb821c22460e2021-12-02T14:40:10ZFibrotic microtissue array to predict anti-fibrosis drug efficacy10.1038/s41467-018-04336-z2041-1723https://doaj.org/article/6ac76a78833f45c899ebfb821c22460e2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04336-zhttps://doaj.org/toc/2041-1723A bottleneck in developing new anti-fibrosis therapies is the absence of suitable in vitro models that recapitulate key features of fibrogenesis. Here the authors develop a tissue-on-a-chip model of lung fibrosis and test the therapeutic efficacy of two recent FDA-approved drugs.Mohammadnabi AsmaniSanjana VelumaniYan LiNicole WawrzyniakIsaac HsiaZhaowei ChenBoris HinzRuogang ZhaoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mohammadnabi Asmani Sanjana Velumani Yan Li Nicole Wawrzyniak Isaac Hsia Zhaowei Chen Boris Hinz Ruogang Zhao Fibrotic microtissue array to predict anti-fibrosis drug efficacy
description	A bottleneck in developing new anti-fibrosis therapies is the absence of suitable in vitro models that recapitulate key features of fibrogenesis. Here the authors develop a tissue-on-a-chip model of lung fibrosis and test the therapeutic efficacy of two recent FDA-approved drugs.
format	article
author	Mohammadnabi Asmani Sanjana Velumani Yan Li Nicole Wawrzyniak Isaac Hsia Zhaowei Chen Boris Hinz Ruogang Zhao
author_facet	Mohammadnabi Asmani Sanjana Velumani Yan Li Nicole Wawrzyniak Isaac Hsia Zhaowei Chen Boris Hinz Ruogang Zhao
author_sort	Mohammadnabi Asmani
title	Fibrotic microtissue array to predict anti-fibrosis drug efficacy
title_short	Fibrotic microtissue array to predict anti-fibrosis drug efficacy
title_full	Fibrotic microtissue array to predict anti-fibrosis drug efficacy
title_fullStr	Fibrotic microtissue array to predict anti-fibrosis drug efficacy
title_full_unstemmed	Fibrotic microtissue array to predict anti-fibrosis drug efficacy
title_sort	fibrotic microtissue array to predict anti-fibrosis drug efficacy
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/6ac76a78833f45c899ebfb821c22460e
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Fibrotic microtissue array to predict anti-fibrosis drug efficacy

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