Fibrotic microtissue array to predict anti-fibrosis drug efficacy
A bottleneck in developing new anti-fibrosis therapies is the absence of suitable in vitro models that recapitulate key features of fibrogenesis. Here the authors develop a tissue-on-a-chip model of lung fibrosis and test the therapeutic efficacy of two recent FDA-approved drugs.
Saved in:
Main Authors: | Mohammadnabi Asmani, Sanjana Velumani, Yan Li, Nicole Wawrzyniak, Isaac Hsia, Zhaowei Chen, Boris Hinz, Ruogang Zhao |
---|---|
Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2018
|
Subjects: | |
Online Access: | https://doaj.org/article/6ac76a78833f45c899ebfb821c22460e |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Microclot array elastometry for integrated measurement of thrombus formation and clot biomechanics under fluid shear
by: Zhaowei Chen, et al.
Published: (2019) -
Microstamped Petri dishes for scanning electrochemical microscopy analysis of arrays of microtissues.
by: Adithya Sridhar, et al.
Published: (2014) -
A model of human lung fibrogenesis for the assessment of anti-fibrotic strategies in idiopathic pulmonary fibrosis
by: Katy M. Roach, et al.
Published: (2018) -
Using the Microwell-mesh to culture microtissues in vitro and as a carrier to implant microtissues in vivo into mice
by: Melissa E. Monterosso, et al.
Published: (2021) -
Isochoric supercooled preservation and revival of human cardiac microtissues
by: Matthew J. Powell-Palm, et al.
Published: (2021)