Ultrasonic actuation of a fine-needle improves biopsy yield

Abstract Despite the ubiquitous use over the past 150 years, the functions of the current medical needle are facilitated only by mechanical shear and cutting by the needle tip, i.e. the lancet. In this study, we demonstrate how nonlinear ultrasonics (NLU) extends the functionality of the medical nee...

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Autores principales:	Emanuele Perra, Eetu Lampsijärvi, Gonçalo Barreto, Muhammad Arif, Tuomas Puranen, Edward Hæggström, Kenneth P. H. Pritzker, Heikki J. Nieminen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6ac85d15a7c24e85b23285311eb942ee
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spelling	oai:doaj.org-article:6ac85d15a7c24e85b23285311eb942ee2021-12-02T18:03:31ZUltrasonic actuation of a fine-needle improves biopsy yield10.1038/s41598-021-87303-x2045-2322https://doaj.org/article/6ac85d15a7c24e85b23285311eb942ee2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87303-xhttps://doaj.org/toc/2045-2322Abstract Despite the ubiquitous use over the past 150 years, the functions of the current medical needle are facilitated only by mechanical shear and cutting by the needle tip, i.e. the lancet. In this study, we demonstrate how nonlinear ultrasonics (NLU) extends the functionality of the medical needle far beyond its present capability. The NLU actions were found to be localized to the proximity of the needle tip, the SonoLancet, but the effects extend to several millimeters from the physical needle boundary. The observed nonlinear phenomena, transient cavitation, fluid streams, translation of micro- and nanoparticles and atomization, were quantitatively characterized. In the fine-needle biopsy application, the SonoLancet contributed to obtaining tissue cores with an increase in tissue yield by 3–6× in different tissue types compared to conventional needle biopsy technique using the same 21G needle. In conclusion, the SonoLancet could be of interest to several other medical applications, including drug or gene delivery, cell modulation, and minimally invasive surgical procedures.Emanuele PerraEetu LampsijärviGonçalo BarretoMuhammad ArifTuomas PuranenEdward HæggströmKenneth P. H. PritzkerHeikki J. NieminenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Emanuele Perra Eetu Lampsijärvi Gonçalo Barreto Muhammad Arif Tuomas Puranen Edward Hæggström Kenneth P. H. Pritzker Heikki J. Nieminen Ultrasonic actuation of a fine-needle improves biopsy yield
description	Abstract Despite the ubiquitous use over the past 150 years, the functions of the current medical needle are facilitated only by mechanical shear and cutting by the needle tip, i.e. the lancet. In this study, we demonstrate how nonlinear ultrasonics (NLU) extends the functionality of the medical needle far beyond its present capability. The NLU actions were found to be localized to the proximity of the needle tip, the SonoLancet, but the effects extend to several millimeters from the physical needle boundary. The observed nonlinear phenomena, transient cavitation, fluid streams, translation of micro- and nanoparticles and atomization, were quantitatively characterized. In the fine-needle biopsy application, the SonoLancet contributed to obtaining tissue cores with an increase in tissue yield by 3–6× in different tissue types compared to conventional needle biopsy technique using the same 21G needle. In conclusion, the SonoLancet could be of interest to several other medical applications, including drug or gene delivery, cell modulation, and minimally invasive surgical procedures.
format	article
author	Emanuele Perra Eetu Lampsijärvi Gonçalo Barreto Muhammad Arif Tuomas Puranen Edward Hæggström Kenneth P. H. Pritzker Heikki J. Nieminen
author_facet	Emanuele Perra Eetu Lampsijärvi Gonçalo Barreto Muhammad Arif Tuomas Puranen Edward Hæggström Kenneth P. H. Pritzker Heikki J. Nieminen
author_sort	Emanuele Perra
title	Ultrasonic actuation of a fine-needle improves biopsy yield
title_short	Ultrasonic actuation of a fine-needle improves biopsy yield
title_full	Ultrasonic actuation of a fine-needle improves biopsy yield
title_fullStr	Ultrasonic actuation of a fine-needle improves biopsy yield
title_full_unstemmed	Ultrasonic actuation of a fine-needle improves biopsy yield
title_sort	ultrasonic actuation of a fine-needle improves biopsy yield
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6ac85d15a7c24e85b23285311eb942ee
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Ultrasonic actuation of a fine-needle improves biopsy yield

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