EFFECT ANTHOCYANIN OF PURPLE POTATO GUNUNG KAWI ON MDA LEVELS, EXPRESSION OF CASPASE-3, AND SPATIAL MEMORY FUNCTION ON DIABETIC WISTAR RATS

Background: Hyperglycemia condition will decline cognitive function. No basic therapy has been found for this. Purple potato anthocyanins are useful as anti-inflammatory, antioxidant, neuroprotectant, and antidiabetic. Objective: Evaluate effect of purple potato’s anthocyanins on MDA levels, brain’...

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Autores principales:	Risma Karlina Prabawati, Retty Ratnawati, Masruroh Rahayu, Ardani Galih Prakosa
Formato:	article
Lenguaje:	EN ID
Publicado:	University of Brawijaya 2019
Materias:	anthocyanins hyperglycemia mda caspase-3 spatial memory function Medicine R Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/6ac8cb30218e44aaa7feaf5bcabe88d3
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spelling	oai:doaj.org-article:6ac8cb30218e44aaa7feaf5bcabe88d32021-11-12T06:51:08ZEFFECT ANTHOCYANIN OF PURPLE POTATO GUNUNG KAWI ON MDA LEVELS, EXPRESSION OF CASPASE-3, AND SPATIAL MEMORY FUNCTION ON DIABETIC WISTAR RATS10.21776/ub.mnj.2019.005.01.62407-67242442-5001https://doaj.org/article/6ac8cb30218e44aaa7feaf5bcabe88d32019-01-01T00:00:00Zhttps://mnj.ub.ac.id/index.php/mnj/article/view/355https://doaj.org/toc/2407-6724https://doaj.org/toc/2442-5001Background: Hyperglycemia condition will decline cognitive function. No basic therapy has been found for this. Purple potato anthocyanins are useful as anti-inflammatory, antioxidant, neuroprotectant, and antidiabetic. Objective: Evaluate effect of purple potato’s anthocyanins on MDA levels, brain’s caspase-3 expressiom, and spatial memory function in diabetic model of Wistar rats. Methods: This is an experimental study using diabetic model rats. The sample was divided into negative and positive control, anthocyanin dose of 10mg/kg, 20mg/kg, and 80mg/kg groups. MDA levels were measured using spectrophotometer, caspase-3 expression with immunohistochemistry, and spatial memory function using Morris water maze test. Results: Tukey test showed that anthocyanin 10, 20, and 80 mg/kg lowering MDA levels, caspase-3 expression, and Morris water maze’s travel time compared to control positive (p = 0.000). But anthocyanin 80 mg/kg make a significant increase on these three variabels compared to 10 and 20 mg/kg groups (p = 0.010). Pearson test showed that there no correlation between anthocyanin’s dose, MDA levels, caspase-3 expression, and Morris water maze test. Conclusion: Anthocyanin doses 10 and 20mg/kg lowering MDA levels and caspase-3 expression, also improves spatial memory function on diabetic model of Wistar rats.Risma Karlina PrabawatiRetty RatnawatiMasruroh RahayuArdani Galih PrakosaUniversity of Brawijayaarticleanthocyaninshyperglycemiamdacaspase-3spatial memory functionMedicineRNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENIDMalang Neurology Journal, Vol 5, Iss 1, Pp 34-41 (2019)
institution	DOAJ
collection	DOAJ
language	EN ID
topic	anthocyanins hyperglycemia mda caspase-3 spatial memory function Medicine R Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	anthocyanins hyperglycemia mda caspase-3 spatial memory function Medicine R Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Risma Karlina Prabawati Retty Ratnawati Masruroh Rahayu Ardani Galih Prakosa EFFECT ANTHOCYANIN OF PURPLE POTATO GUNUNG KAWI ON MDA LEVELS, EXPRESSION OF CASPASE-3, AND SPATIAL MEMORY FUNCTION ON DIABETIC WISTAR RATS
description	Background: Hyperglycemia condition will decline cognitive function. No basic therapy has been found for this. Purple potato anthocyanins are useful as anti-inflammatory, antioxidant, neuroprotectant, and antidiabetic. Objective: Evaluate effect of purple potato’s anthocyanins on MDA levels, brain’s caspase-3 expressiom, and spatial memory function in diabetic model of Wistar rats. Methods: This is an experimental study using diabetic model rats. The sample was divided into negative and positive control, anthocyanin dose of 10mg/kg, 20mg/kg, and 80mg/kg groups. MDA levels were measured using spectrophotometer, caspase-3 expression with immunohistochemistry, and spatial memory function using Morris water maze test. Results: Tukey test showed that anthocyanin 10, 20, and 80 mg/kg lowering MDA levels, caspase-3 expression, and Morris water maze’s travel time compared to control positive (p = 0.000). But anthocyanin 80 mg/kg make a significant increase on these three variabels compared to 10 and 20 mg/kg groups (p = 0.010). Pearson test showed that there no correlation between anthocyanin’s dose, MDA levels, caspase-3 expression, and Morris water maze test. Conclusion: Anthocyanin doses 10 and 20mg/kg lowering MDA levels and caspase-3 expression, also improves spatial memory function on diabetic model of Wistar rats.
format	article
author	Risma Karlina Prabawati Retty Ratnawati Masruroh Rahayu Ardani Galih Prakosa
author_facet	Risma Karlina Prabawati Retty Ratnawati Masruroh Rahayu Ardani Galih Prakosa
author_sort	Risma Karlina Prabawati
title	EFFECT ANTHOCYANIN OF PURPLE POTATO GUNUNG KAWI ON MDA LEVELS, EXPRESSION OF CASPASE-3, AND SPATIAL MEMORY FUNCTION ON DIABETIC WISTAR RATS
title_short	EFFECT ANTHOCYANIN OF PURPLE POTATO GUNUNG KAWI ON MDA LEVELS, EXPRESSION OF CASPASE-3, AND SPATIAL MEMORY FUNCTION ON DIABETIC WISTAR RATS
title_full	EFFECT ANTHOCYANIN OF PURPLE POTATO GUNUNG KAWI ON MDA LEVELS, EXPRESSION OF CASPASE-3, AND SPATIAL MEMORY FUNCTION ON DIABETIC WISTAR RATS
title_fullStr	EFFECT ANTHOCYANIN OF PURPLE POTATO GUNUNG KAWI ON MDA LEVELS, EXPRESSION OF CASPASE-3, AND SPATIAL MEMORY FUNCTION ON DIABETIC WISTAR RATS
title_full_unstemmed	EFFECT ANTHOCYANIN OF PURPLE POTATO GUNUNG KAWI ON MDA LEVELS, EXPRESSION OF CASPASE-3, AND SPATIAL MEMORY FUNCTION ON DIABETIC WISTAR RATS
title_sort	effect anthocyanin of purple potato gunung kawi on mda levels, expression of caspase-3, and spatial memory function on diabetic wistar rats
publisher	University of Brawijaya
publishDate	2019
url	https://doaj.org/article/6ac8cb30218e44aaa7feaf5bcabe88d3
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_version_	1718431113456648192

EFFECT ANTHOCYANIN OF PURPLE POTATO GUNUNG KAWI ON MDA LEVELS, EXPRESSION OF CASPASE-3, AND SPATIAL MEMORY FUNCTION ON DIABETIC WISTAR RATS

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