EFFECT ANTHOCYANIN OF PURPLE POTATO GUNUNG KAWI ON MDA LEVELS, EXPRESSION OF CASPASE-3, AND SPATIAL MEMORY FUNCTION ON DIABETIC WISTAR RATS
Background: Hyperglycemia condition will decline cognitive function. No basic therapy has been found for this. Purple potato anthocyanins are useful as anti-inflammatory, antioxidant, neuroprotectant, and antidiabetic. Objective: Evaluate effect of purple potato’s anthocyanins on MDA levels, brain’...
Guardado en:
Autores principales: | , , , |
---|---|
Formato: | article |
Lenguaje: | EN ID |
Publicado: |
University of Brawijaya
2019
|
Materias: | |
Acceso en línea: | https://doaj.org/article/6ac8cb30218e44aaa7feaf5bcabe88d3 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
id |
oai:doaj.org-article:6ac8cb30218e44aaa7feaf5bcabe88d3 |
---|---|
record_format |
dspace |
spelling |
oai:doaj.org-article:6ac8cb30218e44aaa7feaf5bcabe88d32021-11-12T06:51:08ZEFFECT ANTHOCYANIN OF PURPLE POTATO GUNUNG KAWI ON MDA LEVELS, EXPRESSION OF CASPASE-3, AND SPATIAL MEMORY FUNCTION ON DIABETIC WISTAR RATS10.21776/ub.mnj.2019.005.01.62407-67242442-5001https://doaj.org/article/6ac8cb30218e44aaa7feaf5bcabe88d32019-01-01T00:00:00Zhttps://mnj.ub.ac.id/index.php/mnj/article/view/355https://doaj.org/toc/2407-6724https://doaj.org/toc/2442-5001Background: Hyperglycemia condition will decline cognitive function. No basic therapy has been found for this. Purple potato anthocyanins are useful as anti-inflammatory, antioxidant, neuroprotectant, and antidiabetic. Objective: Evaluate effect of purple potato’s anthocyanins on MDA levels, brain’s caspase-3 expressiom, and spatial memory function in diabetic model of Wistar rats. Methods: This is an experimental study using diabetic model rats. The sample was divided into negative and positive control, anthocyanin dose of 10mg/kg, 20mg/kg, and 80mg/kg groups. MDA levels were measured using spectrophotometer, caspase-3 expression with immunohistochemistry, and spatial memory function using Morris water maze test. Results: Tukey test showed that anthocyanin 10, 20, and 80 mg/kg lowering MDA levels, caspase-3 expression, and Morris water maze’s travel time compared to control positive (p = 0.000). But anthocyanin 80 mg/kg make a significant increase on these three variabels compared to 10 and 20 mg/kg groups (p = 0.010). Pearson test showed that there no correlation between anthocyanin’s dose, MDA levels, caspase-3 expression, and Morris water maze test. Conclusion: Anthocyanin doses 10 and 20mg/kg lowering MDA levels and caspase-3 expression, also improves spatial memory function on diabetic model of Wistar rats.Risma Karlina PrabawatiRetty RatnawatiMasruroh RahayuArdani Galih PrakosaUniversity of Brawijayaarticleanthocyaninshyperglycemiamdacaspase-3spatial memory functionMedicineRNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENIDMalang Neurology Journal, Vol 5, Iss 1, Pp 34-41 (2019) |
institution |
DOAJ |
collection |
DOAJ |
language |
EN ID |
topic |
anthocyanins hyperglycemia mda caspase-3 spatial memory function Medicine R Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 |
spellingShingle |
anthocyanins hyperglycemia mda caspase-3 spatial memory function Medicine R Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Risma Karlina Prabawati Retty Ratnawati Masruroh Rahayu Ardani Galih Prakosa EFFECT ANTHOCYANIN OF PURPLE POTATO GUNUNG KAWI ON MDA LEVELS, EXPRESSION OF CASPASE-3, AND SPATIAL MEMORY FUNCTION ON DIABETIC WISTAR RATS |
description |
Background: Hyperglycemia condition will decline cognitive function. No basic therapy has been found for this. Purple potato anthocyanins are useful as anti-inflammatory, antioxidant, neuroprotectant, and antidiabetic.
Objective: Evaluate effect of purple potato’s anthocyanins on MDA levels, brain’s caspase-3 expressiom, and spatial memory function in diabetic model of Wistar rats.
Methods: This is an experimental study using diabetic model rats. The sample was divided into negative and positive control, anthocyanin dose of 10mg/kg, 20mg/kg, and 80mg/kg groups. MDA levels were measured using spectrophotometer, caspase-3 expression with immunohistochemistry, and spatial memory function using Morris water maze test.
Results: Tukey test showed that anthocyanin 10, 20, and 80 mg/kg lowering MDA levels, caspase-3 expression, and Morris water maze’s travel time compared to control positive (p = 0.000). But anthocyanin 80 mg/kg make a significant increase on these three variabels compared to 10 and 20 mg/kg groups (p = 0.010). Pearson test showed that there no correlation between anthocyanin’s dose, MDA levels, caspase-3 expression, and Morris water maze test.
Conclusion: Anthocyanin doses 10 and 20mg/kg lowering MDA levels and caspase-3 expression, also improves spatial memory function on diabetic model of Wistar rats. |
format |
article |
author |
Risma Karlina Prabawati Retty Ratnawati Masruroh Rahayu Ardani Galih Prakosa |
author_facet |
Risma Karlina Prabawati Retty Ratnawati Masruroh Rahayu Ardani Galih Prakosa |
author_sort |
Risma Karlina Prabawati |
title |
EFFECT ANTHOCYANIN OF PURPLE POTATO GUNUNG KAWI ON MDA LEVELS, EXPRESSION OF CASPASE-3, AND SPATIAL MEMORY FUNCTION ON DIABETIC WISTAR RATS |
title_short |
EFFECT ANTHOCYANIN OF PURPLE POTATO GUNUNG KAWI ON MDA LEVELS, EXPRESSION OF CASPASE-3, AND SPATIAL MEMORY FUNCTION ON DIABETIC WISTAR RATS |
title_full |
EFFECT ANTHOCYANIN OF PURPLE POTATO GUNUNG KAWI ON MDA LEVELS, EXPRESSION OF CASPASE-3, AND SPATIAL MEMORY FUNCTION ON DIABETIC WISTAR RATS |
title_fullStr |
EFFECT ANTHOCYANIN OF PURPLE POTATO GUNUNG KAWI ON MDA LEVELS, EXPRESSION OF CASPASE-3, AND SPATIAL MEMORY FUNCTION ON DIABETIC WISTAR RATS |
title_full_unstemmed |
EFFECT ANTHOCYANIN OF PURPLE POTATO GUNUNG KAWI ON MDA LEVELS, EXPRESSION OF CASPASE-3, AND SPATIAL MEMORY FUNCTION ON DIABETIC WISTAR RATS |
title_sort |
effect anthocyanin of purple potato gunung kawi on mda levels, expression of caspase-3, and spatial memory function on diabetic wistar rats |
publisher |
University of Brawijaya |
publishDate |
2019 |
url |
https://doaj.org/article/6ac8cb30218e44aaa7feaf5bcabe88d3 |
work_keys_str_mv |
AT rismakarlinaprabawati effectanthocyaninofpurplepotatogunungkawionmdalevelsexpressionofcaspase3andspatialmemoryfunctionondiabeticwistarrats AT rettyratnawati effectanthocyaninofpurplepotatogunungkawionmdalevelsexpressionofcaspase3andspatialmemoryfunctionondiabeticwistarrats AT masrurohrahayu effectanthocyaninofpurplepotatogunungkawionmdalevelsexpressionofcaspase3andspatialmemoryfunctionondiabeticwistarrats AT ardanigalihprakosa effectanthocyaninofpurplepotatogunungkawionmdalevelsexpressionofcaspase3andspatialmemoryfunctionondiabeticwistarrats |
_version_ |
1718431113456648192 |