WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation

Overexpression of RAS proteins is frequently observed in patients with hepatocellular carcinoma. Here, the authors identify an HRAS binding protein, the E3 ubiquitin ligase WDR76, which promotes HRAS degradation, thus functioning as a tumour suppressor in liver cancer

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Autores principales:	Woo-Jeong Jeong, Jong-Chan Park, Woo-Shin Kim, Eun Ji Ro, Soung Hoo Jeon, Sang-Kyu Lee, Young Nyun Park, Do Sik Min, Kang-Yell Choi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6ac8e7eb82964962ab6b3cd87acf4c7b
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spelling	oai:doaj.org-article:6ac8e7eb82964962ab6b3cd87acf4c7b2021-12-02T14:40:18ZWDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation10.1038/s41467-018-08230-62041-1723https://doaj.org/article/6ac8e7eb82964962ab6b3cd87acf4c7b2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08230-6https://doaj.org/toc/2041-1723Overexpression of RAS proteins is frequently observed in patients with hepatocellular carcinoma. Here, the authors identify an HRAS binding protein, the E3 ubiquitin ligase WDR76, which promotes HRAS degradation, thus functioning as a tumour suppressor in liver cancerWoo-Jeong JeongJong-Chan ParkWoo-Shin KimEun Ji RoSoung Hoo JeonSang-Kyu LeeYoung Nyun ParkDo Sik MinKang-Yell ChoiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Woo-Jeong Jeong Jong-Chan Park Woo-Shin Kim Eun Ji Ro Soung Hoo Jeon Sang-Kyu Lee Young Nyun Park Do Sik Min Kang-Yell Choi WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation
description	Overexpression of RAS proteins is frequently observed in patients with hepatocellular carcinoma. Here, the authors identify an HRAS binding protein, the E3 ubiquitin ligase WDR76, which promotes HRAS degradation, thus functioning as a tumour suppressor in liver cancer
format	article
author	Woo-Jeong Jeong Jong-Chan Park Woo-Shin Kim Eun Ji Ro Soung Hoo Jeon Sang-Kyu Lee Young Nyun Park Do Sik Min Kang-Yell Choi
author_facet	Woo-Jeong Jeong Jong-Chan Park Woo-Shin Kim Eun Ji Ro Soung Hoo Jeon Sang-Kyu Lee Young Nyun Park Do Sik Min Kang-Yell Choi
author_sort	Woo-Jeong Jeong
title	WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation
title_short	WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation
title_full	WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation
title_fullStr	WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation
title_full_unstemmed	WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation
title_sort	wdr76 is a ras binding protein that functions as a tumor suppressor via ras degradation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/6ac8e7eb82964962ab6b3cd87acf4c7b
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WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation

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