Melanocytic or Not? Dermoscopy and Reflectance Confocal Microscopy for Lesions Difficult to Diagnose: A Cross-Sectional Diagnostic Accuracy Study

Background: Different techniques for non-invasive skin examination and early diagnosis of skin lesions are available nowadays, being dermoscopy and reflectance confocal microscopy (RCM) the most diffused ones. Several studies supported the complementary use of dermoscopy and RCM that improves diagn...

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Autores principales:	Camila Scharf, Giuseppe Argenziano, Gabriella Brancaccio, Gaetano Licata, Andrea Ronchi, Elvira Moscarella
Formato:	article
Lenguaje:	EN
Publicado:	Mattioli1885 2021
Materias:	skin cancer melanocytic skin cancer reflectance confocal microscopy diagnostic dermatology dermoscopy Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/6acb8fa3ce7e4078b29e4119cf5c838c
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spelling	oai:doaj.org-article:6acb8fa3ce7e4078b29e4119cf5c838c2021-11-15T15:17:27ZMelanocytic or Not? Dermoscopy and Reflectance Confocal Microscopy for Lesions Difficult to Diagnose: A Cross-Sectional Diagnostic Accuracy Study10.5826/dpc.1104a1272160-9381https://doaj.org/article/6acb8fa3ce7e4078b29e4119cf5c838c2021-09-01T00:00:00Zhttps://dpcj.org/index.php/dpc/article/view/1642https://doaj.org/toc/2160-9381 Background: Different techniques for non-invasive skin examination and early diagnosis of skin lesions are available nowadays, being dermoscopy and reflectance confocal microscopy (RCM) the most diffused ones. Several studies supported the complementary use of dermoscopy and RCM that improves diagnostic accuracy when dealing with melanocytic lesions. Objectives: To analyze RCM diagnostic accuracy in the differential diagnosis between melanocytic and non-melanocytic lesions. Methods: This is a cohort selected cross-sectional study conducted at the Dermatology Unit of the University of Campania L. Vanvitelli, Naples, Italy, from 2012 to 2020. We searched the image database for all excised lesions for which the clinical and dermatoscopic differential diagnosis was between melanocytic and non-melanocytic and for which an RCM examination was performed. Sensitivity, specificity, and diagnostic accuracy values were estimated. Results: The study included 53 cases that were found to have disagreement between clinical, histological and RCM diagnosis, of which, in 31 cases the differential diagnosis was melanocytic vs non-melanocytic lesion. The RCM reached a specificity of 87% (95% CI: 0.73-1) and a sensitivity of 62.5% (95% CI: 0.29-0.96) in the present sample. Diagnostic accuracy was 80.6% (95% CI: 0.67-0.94). Conclusion: RCM has a high specificity in differentiating between difficult-to-diagnose melanocytic and non-melanocytic lesions. Camila ScharfGiuseppe ArgenzianoGabriella BrancaccioGaetano LicataAndrea RonchiElvira MoscarellaMattioli1885articleskin cancermelanocytic skin cancerreflectance confocal microscopydiagnostic dermatologydermoscopyDermatologyRL1-803ENDermatology Practical & Conceptual (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	skin cancer melanocytic skin cancer reflectance confocal microscopy diagnostic dermatology dermoscopy Dermatology RL1-803
spellingShingle	skin cancer melanocytic skin cancer reflectance confocal microscopy diagnostic dermatology dermoscopy Dermatology RL1-803 Camila Scharf Giuseppe Argenziano Gabriella Brancaccio Gaetano Licata Andrea Ronchi Elvira Moscarella Melanocytic or Not? Dermoscopy and Reflectance Confocal Microscopy for Lesions Difficult to Diagnose: A Cross-Sectional Diagnostic Accuracy Study
description	Background: Different techniques for non-invasive skin examination and early diagnosis of skin lesions are available nowadays, being dermoscopy and reflectance confocal microscopy (RCM) the most diffused ones. Several studies supported the complementary use of dermoscopy and RCM that improves diagnostic accuracy when dealing with melanocytic lesions. Objectives: To analyze RCM diagnostic accuracy in the differential diagnosis between melanocytic and non-melanocytic lesions. Methods: This is a cohort selected cross-sectional study conducted at the Dermatology Unit of the University of Campania L. Vanvitelli, Naples, Italy, from 2012 to 2020. We searched the image database for all excised lesions for which the clinical and dermatoscopic differential diagnosis was between melanocytic and non-melanocytic and for which an RCM examination was performed. Sensitivity, specificity, and diagnostic accuracy values were estimated. Results: The study included 53 cases that were found to have disagreement between clinical, histological and RCM diagnosis, of which, in 31 cases the differential diagnosis was melanocytic vs non-melanocytic lesion. The RCM reached a specificity of 87% (95% CI: 0.73-1) and a sensitivity of 62.5% (95% CI: 0.29-0.96) in the present sample. Diagnostic accuracy was 80.6% (95% CI: 0.67-0.94). Conclusion: RCM has a high specificity in differentiating between difficult-to-diagnose melanocytic and non-melanocytic lesions.
format	article
author	Camila Scharf Giuseppe Argenziano Gabriella Brancaccio Gaetano Licata Andrea Ronchi Elvira Moscarella
author_facet	Camila Scharf Giuseppe Argenziano Gabriella Brancaccio Gaetano Licata Andrea Ronchi Elvira Moscarella
author_sort	Camila Scharf
title	Melanocytic or Not? Dermoscopy and Reflectance Confocal Microscopy for Lesions Difficult to Diagnose: A Cross-Sectional Diagnostic Accuracy Study
title_short	Melanocytic or Not? Dermoscopy and Reflectance Confocal Microscopy for Lesions Difficult to Diagnose: A Cross-Sectional Diagnostic Accuracy Study
title_full	Melanocytic or Not? Dermoscopy and Reflectance Confocal Microscopy for Lesions Difficult to Diagnose: A Cross-Sectional Diagnostic Accuracy Study
title_fullStr	Melanocytic or Not? Dermoscopy and Reflectance Confocal Microscopy for Lesions Difficult to Diagnose: A Cross-Sectional Diagnostic Accuracy Study
title_full_unstemmed	Melanocytic or Not? Dermoscopy and Reflectance Confocal Microscopy for Lesions Difficult to Diagnose: A Cross-Sectional Diagnostic Accuracy Study
title_sort	melanocytic or not? dermoscopy and reflectance confocal microscopy for lesions difficult to diagnose: a cross-sectional diagnostic accuracy study
publisher	Mattioli1885
publishDate	2021
url	https://doaj.org/article/6acb8fa3ce7e4078b29e4119cf5c838c
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Melanocytic or Not? Dermoscopy and Reflectance Confocal Microscopy for Lesions Difficult to Diagnose: A Cross-Sectional Diagnostic Accuracy Study

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