SARS CoV-2 Delta variant exhibits enhanced infectivity and a minor decrease in neutralization sensitivity to convalescent or post-vaccination sera

Summary: Since their identification, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Kappa and Delta have rapidly spread to become globally dominant. However, their infectivity and sensitivity to administered vaccines have not been documented. We monitored the neutralization potential o...

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Autores principales:	Alona Kuzmina, Seraj Wattad, Yara Khalaila, Aner Ottolenghi, Benyamin Rosental, Stanislav Engel, Elli Rosenberg, Ran Taube
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Immunology Virology Science Q
Acceso en línea:	https://doaj.org/article/6acd749f99c54f8c87bec51ad0232dd3
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spelling	oai:doaj.org-article:6acd749f99c54f8c87bec51ad0232dd32021-12-04T04:35:32ZSARS CoV-2 Delta variant exhibits enhanced infectivity and a minor decrease in neutralization sensitivity to convalescent or post-vaccination sera2589-004210.1016/j.isci.2021.103467https://doaj.org/article/6acd749f99c54f8c87bec51ad0232dd32021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589004221014383https://doaj.org/toc/2589-0042Summary: Since their identification, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Kappa and Delta have rapidly spread to become globally dominant. However, their infectivity and sensitivity to administered vaccines have not been documented. We monitored the neutralization potential of convalescent or BNT162b2 post-vaccination sera against Kappa and Delta SARS-CoV-2 pseudoviruses. We show that both variants were successfully neutralized by convalescent and post-vaccination sera, exhibiting a mild decrease in their neutralization sensitivity. Of the two variants, Delta presented enhanced infectivity levels compared with Kappa or wild-type SARS-CoV-2. Nevertheless, both variants were not as infectious or resistant to post-vaccination sera as the Beta variant of concern. Interestingly, the Delta plus variant (AY.1/B.1.617.2.1) exhibited high resistance to post-vaccination sera, similar to that of the Beta SARS-CoV-2. However, its infectivity levels were close to those of wild-type SARS-CoV-2. These results account for the worldwide prevalence of Delta variant of concern and confirm the efficacy of the BNT162b2 vaccine against circulating other Delta variants.Alona KuzminaSeraj WattadYara KhalailaAner OttolenghiBenyamin RosentalStanislav EngelElli RosenbergRan TaubeElsevierarticleImmunologyVirologyScienceQENiScience, Vol 24, Iss 12, Pp 103467- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunology Virology Science Q
spellingShingle	Immunology Virology Science Q Alona Kuzmina Seraj Wattad Yara Khalaila Aner Ottolenghi Benyamin Rosental Stanislav Engel Elli Rosenberg Ran Taube SARS CoV-2 Delta variant exhibits enhanced infectivity and a minor decrease in neutralization sensitivity to convalescent or post-vaccination sera
description	Summary: Since their identification, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Kappa and Delta have rapidly spread to become globally dominant. However, their infectivity and sensitivity to administered vaccines have not been documented. We monitored the neutralization potential of convalescent or BNT162b2 post-vaccination sera against Kappa and Delta SARS-CoV-2 pseudoviruses. We show that both variants were successfully neutralized by convalescent and post-vaccination sera, exhibiting a mild decrease in their neutralization sensitivity. Of the two variants, Delta presented enhanced infectivity levels compared with Kappa or wild-type SARS-CoV-2. Nevertheless, both variants were not as infectious or resistant to post-vaccination sera as the Beta variant of concern. Interestingly, the Delta plus variant (AY.1/B.1.617.2.1) exhibited high resistance to post-vaccination sera, similar to that of the Beta SARS-CoV-2. However, its infectivity levels were close to those of wild-type SARS-CoV-2. These results account for the worldwide prevalence of Delta variant of concern and confirm the efficacy of the BNT162b2 vaccine against circulating other Delta variants.
format	article
author	Alona Kuzmina Seraj Wattad Yara Khalaila Aner Ottolenghi Benyamin Rosental Stanislav Engel Elli Rosenberg Ran Taube
author_facet	Alona Kuzmina Seraj Wattad Yara Khalaila Aner Ottolenghi Benyamin Rosental Stanislav Engel Elli Rosenberg Ran Taube
author_sort	Alona Kuzmina
title	SARS CoV-2 Delta variant exhibits enhanced infectivity and a minor decrease in neutralization sensitivity to convalescent or post-vaccination sera
title_short	SARS CoV-2 Delta variant exhibits enhanced infectivity and a minor decrease in neutralization sensitivity to convalescent or post-vaccination sera
title_full	SARS CoV-2 Delta variant exhibits enhanced infectivity and a minor decrease in neutralization sensitivity to convalescent or post-vaccination sera
title_fullStr	SARS CoV-2 Delta variant exhibits enhanced infectivity and a minor decrease in neutralization sensitivity to convalescent or post-vaccination sera
title_full_unstemmed	SARS CoV-2 Delta variant exhibits enhanced infectivity and a minor decrease in neutralization sensitivity to convalescent or post-vaccination sera
title_sort	sars cov-2 delta variant exhibits enhanced infectivity and a minor decrease in neutralization sensitivity to convalescent or post-vaccination sera
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/6acd749f99c54f8c87bec51ad0232dd3
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SARS CoV-2 Delta variant exhibits enhanced infectivity and a minor decrease in neutralization sensitivity to convalescent or post-vaccination sera

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