The anti-cancer drugs curaxins target spatial genome organization

The anti-cancer drugs curaxins target spatial genome organization

Curaxins are a recently discovered class of anti-cancer agents that disturbs DNA/histone interactions within. Here the authors provide evidence that curaxins affect the spatial genome organization and compromise enhancer-promoter communication necessary for expression of several oncogenes, including...

Full description

Saved in:
Bibliographic Details
Main Authors: Omar L. Kantidze, Artem V. Luzhin, Ekaterina V. Nizovtseva, Alfiya Safina, Maria E. Valieva, Arkadiy K. Golov, Artem K. Velichko, Alexander V. Lyubitelev, Alexey V. Feofanov, Katerina V. Gurova, Vasily M. Studitsky, Sergey V. Razin
Format: article
Language:EN
Published: Nature Portfolio 2019
Subjects:
Science
Q
Online Access:https://doaj.org/article/6ad5ed2c5629478aaf374797be05a1e6
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Curaxins are a recently discovered class of anti-cancer agents that disturbs DNA/histone interactions within. Here the authors provide evidence that curaxins affect the spatial genome organization and compromise enhancer-promoter communication necessary for expression of several oncogenes, including MYC.

Similar Items