The anti-cancer drugs curaxins target spatial genome organization

Curaxins are a recently discovered class of anti-cancer agents that disturbs DNA/histone interactions within. Here the authors provide evidence that curaxins affect the spatial genome organization and compromise enhancer-promoter communication necessary for expression of several oncogenes, including...

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Autores principales:	Omar L. Kantidze, Artem V. Luzhin, Ekaterina V. Nizovtseva, Alfiya Safina, Maria E. Valieva, Arkadiy K. Golov, Artem K. Velichko, Alexander V. Lyubitelev, Alexey V. Feofanov, Katerina V. Gurova, Vasily M. Studitsky, Sergey V. Razin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6ad5ed2c5629478aaf374797be05a1e6
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spelling	oai:doaj.org-article:6ad5ed2c5629478aaf374797be05a1e62021-12-02T14:40:18ZThe anti-cancer drugs curaxins target spatial genome organization10.1038/s41467-019-09500-72041-1723https://doaj.org/article/6ad5ed2c5629478aaf374797be05a1e62019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09500-7https://doaj.org/toc/2041-1723Curaxins are a recently discovered class of anti-cancer agents that disturbs DNA/histone interactions within. Here the authors provide evidence that curaxins affect the spatial genome organization and compromise enhancer-promoter communication necessary for expression of several oncogenes, including MYC.Omar L. KantidzeArtem V. LuzhinEkaterina V. NizovtsevaAlfiya SafinaMaria E. ValievaArkadiy K. GolovArtem K. VelichkoAlexander V. LyubitelevAlexey V. FeofanovKaterina V. GurovaVasily M. StuditskySergey V. RazinNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Omar L. Kantidze Artem V. Luzhin Ekaterina V. Nizovtseva Alfiya Safina Maria E. Valieva Arkadiy K. Golov Artem K. Velichko Alexander V. Lyubitelev Alexey V. Feofanov Katerina V. Gurova Vasily M. Studitsky Sergey V. Razin The anti-cancer drugs curaxins target spatial genome organization
description	Curaxins are a recently discovered class of anti-cancer agents that disturbs DNA/histone interactions within. Here the authors provide evidence that curaxins affect the spatial genome organization and compromise enhancer-promoter communication necessary for expression of several oncogenes, including MYC.
format	article
author	Omar L. Kantidze Artem V. Luzhin Ekaterina V. Nizovtseva Alfiya Safina Maria E. Valieva Arkadiy K. Golov Artem K. Velichko Alexander V. Lyubitelev Alexey V. Feofanov Katerina V. Gurova Vasily M. Studitsky Sergey V. Razin
author_facet	Omar L. Kantidze Artem V. Luzhin Ekaterina V. Nizovtseva Alfiya Safina Maria E. Valieva Arkadiy K. Golov Artem K. Velichko Alexander V. Lyubitelev Alexey V. Feofanov Katerina V. Gurova Vasily M. Studitsky Sergey V. Razin
author_sort	Omar L. Kantidze
title	The anti-cancer drugs curaxins target spatial genome organization
title_short	The anti-cancer drugs curaxins target spatial genome organization
title_full	The anti-cancer drugs curaxins target spatial genome organization
title_fullStr	The anti-cancer drugs curaxins target spatial genome organization
title_full_unstemmed	The anti-cancer drugs curaxins target spatial genome organization
title_sort	anti-cancer drugs curaxins target spatial genome organization
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/6ad5ed2c5629478aaf374797be05a1e6
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The anti-cancer drugs curaxins target spatial genome organization

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