Anti-TLR7 Antibody Protects Against Lupus Nephritis in NZBWF1 Mice by Targeting B Cells and Patrolling Monocytes

Anti-TLR7 Antibody Protects Against Lupus Nephritis in NZBWF1 Mice by Targeting B Cells and Patrolling Monocytes

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by autoantibody production and multiple organ damage. Toll-like receptor 7 (TLR7), an innate immune RNA sensor expressed in monocytes/macrophages, dendritic cells (DCs), and B cells, promotes disease progression. However, litt...

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Bibliographic Details
Main Authors: Yusuke Murakami, Ryutaro Fukui, Reika Tanaka, Yuji Motoi, Atsuo Kanno, Ryota Sato, Kiyoshi Yamaguchi, Hirofumi Amano, Yoichi Furukawa, Hitoshi Suzuki, Yusuke Suzuki, Naoto Tamura, Naomi Yamashita, Kensuke Miyake
Format: article
Language:EN
Published: Frontiers Media S.A. 2021
Subjects:
toll-like receptor
lupus nephritis
inhibitory monoclonal antibody
monocytes
autoantibody
Immunologic diseases. Allergy
RC581-607
Online Access:https://doaj.org/article/6ad713420c2a44b8aaac85ef2150dffd
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https://doaj.org/article/6ad713420c2a44b8aaac85ef2150dffd

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