The relation between parietal GABA concentration and numerical skills

Abstract Several scientific, engineering, and medical advancements are based on breakthroughs made by people who excel in mathematics. Our current understanding of the underlying brain networks stems primarily from anatomical and functional investigations, but our knowledge of how neurotransmitters...

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Autores principales:	George Zacharopoulos, Francesco Sella, Uzay Emir, Roi Cohen Kadosh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6ad992ee01c94823a9ba441c4b288d16
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spelling	oai:doaj.org-article:6ad992ee01c94823a9ba441c4b288d162021-12-02T19:09:30ZThe relation between parietal GABA concentration and numerical skills10.1038/s41598-021-95370-32045-2322https://doaj.org/article/6ad992ee01c94823a9ba441c4b288d162021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95370-3https://doaj.org/toc/2045-2322Abstract Several scientific, engineering, and medical advancements are based on breakthroughs made by people who excel in mathematics. Our current understanding of the underlying brain networks stems primarily from anatomical and functional investigations, but our knowledge of how neurotransmitters subserve numerical skills, the building block of mathematics, is scarce. Using 1H magnetic resonance spectroscopy (N = 54, 3T, semi-LASER sequence, TE = 32 ms, TR = 3.5 s), the study examined the relation between numerical skills and the brain’s major inhibitory (GABA) and excitatory (glutamate) neurotransmitters. A negative association was found between the performance in a number sequences task and the resting concentration of GABA within the left intraparietal sulcus (IPS), a key region supporting numeracy. The relation between GABA in the IPS and number sequences was specific to (1) parietal but not frontal regions and to (2) GABA but not glutamate. It was additionally found that the resting functional connectivity of the left IPS and the left superior frontal gyrus was positively associated with number sequences performance. However, resting GABA concentration within the IPS explained number sequences performance above and beyond the resting frontoparietal connectivity measure. Our findings further motivate the study of inhibition mechanisms in the human brain and significantly contribute to our current understanding of numerical cognition's biological bases.George ZacharopoulosFrancesco SellaUzay EmirRoi Cohen KadoshNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q George Zacharopoulos Francesco Sella Uzay Emir Roi Cohen Kadosh The relation between parietal GABA concentration and numerical skills
description	Abstract Several scientific, engineering, and medical advancements are based on breakthroughs made by people who excel in mathematics. Our current understanding of the underlying brain networks stems primarily from anatomical and functional investigations, but our knowledge of how neurotransmitters subserve numerical skills, the building block of mathematics, is scarce. Using 1H magnetic resonance spectroscopy (N = 54, 3T, semi-LASER sequence, TE = 32 ms, TR = 3.5 s), the study examined the relation between numerical skills and the brain’s major inhibitory (GABA) and excitatory (glutamate) neurotransmitters. A negative association was found between the performance in a number sequences task and the resting concentration of GABA within the left intraparietal sulcus (IPS), a key region supporting numeracy. The relation between GABA in the IPS and number sequences was specific to (1) parietal but not frontal regions and to (2) GABA but not glutamate. It was additionally found that the resting functional connectivity of the left IPS and the left superior frontal gyrus was positively associated with number sequences performance. However, resting GABA concentration within the IPS explained number sequences performance above and beyond the resting frontoparietal connectivity measure. Our findings further motivate the study of inhibition mechanisms in the human brain and significantly contribute to our current understanding of numerical cognition's biological bases.
format	article
author	George Zacharopoulos Francesco Sella Uzay Emir Roi Cohen Kadosh
author_facet	George Zacharopoulos Francesco Sella Uzay Emir Roi Cohen Kadosh
author_sort	George Zacharopoulos
title	The relation between parietal GABA concentration and numerical skills
title_short	The relation between parietal GABA concentration and numerical skills
title_full	The relation between parietal GABA concentration and numerical skills
title_fullStr	The relation between parietal GABA concentration and numerical skills
title_full_unstemmed	The relation between parietal GABA concentration and numerical skills
title_sort	relation between parietal gaba concentration and numerical skills
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6ad992ee01c94823a9ba441c4b288d16
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The relation between parietal GABA concentration and numerical skills

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