Multimodal neuroimaging markers of variation in cognitive ability in older HIV+ men.

<h4>Objective</h4>This study used converging methods to examine the neural substrates of cognitive ability in middle-aged and older men with well-controlled HIV infection.<h4>Methods</h4>Seventy-six HIV+ men on antiretroviral treatment completed an auditory oddball task and a...

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Autores principales:	Ana Lucia Fernandez Cruz, Chien-Ming Chen, Ryan Sanford, D Louis Collins, Marie-Josée Brouillette, Nancy E Mayo, Lesley K Fellows
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6adaae66ec674208a8a7712f4d619297
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spelling	oai:doaj.org-article:6adaae66ec674208a8a7712f4d6192972021-12-02T20:04:49ZMultimodal neuroimaging markers of variation in cognitive ability in older HIV+ men.1932-620310.1371/journal.pone.0243670https://doaj.org/article/6adaae66ec674208a8a7712f4d6192972021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0243670https://doaj.org/toc/1932-6203<h4>Objective</h4>This study used converging methods to examine the neural substrates of cognitive ability in middle-aged and older men with well-controlled HIV infection.<h4>Methods</h4>Seventy-six HIV+ men on antiretroviral treatment completed an auditory oddball task and an inhibitory control (Simon) task while time-locked high-density EEG was acquired; 66 had usable EEG data from one or both tasks; structural MRI was available for 43. We investigated relationships between task-evoked EEG responses, cognitive ability and immunocompromise. We also explored the structural correlates of these EEG markers in the sub-sample with complete EEG and MRI data (N = 27).<h4>Results</h4>EEG activity was associated with cognitive ability at later (P300) but not earlier stages of both tasks. Only the oddball task P300 was reliably associated with HIV severity (nadir CD4). Source localization confirmed that the tasks engaged partially distinct circuits. Thalamus volume correlated with oddball task P300 amplitude, while globus pallidus volume was related to the P300 in both tasks.<h4>Interpretation</h4>This is the first study to use task-evoked EEG to identify neural correlates of individual differences in cognition in men living with well-controlled HIV infection, and to explore the structural basis of the EEG markers. We found that EEG responses evoked by the oddball task are more reliably related to cognitive performance than those evoked by the Simon task. We also provide preliminary evidence for a subcortical contribution to the effects of HIV infection severity on P300 amplitudes. These results suggest brain mechanisms and candidate biomarkers for individual differences in cognition in HIV.Ana Lucia Fernandez CruzChien-Ming ChenRyan SanfordD Louis CollinsMarie-Josée BrouilletteNancy E MayoLesley K FellowsPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0243670 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ana Lucia Fernandez Cruz Chien-Ming Chen Ryan Sanford D Louis Collins Marie-Josée Brouillette Nancy E Mayo Lesley K Fellows Multimodal neuroimaging markers of variation in cognitive ability in older HIV+ men.
description	<h4>Objective</h4>This study used converging methods to examine the neural substrates of cognitive ability in middle-aged and older men with well-controlled HIV infection.<h4>Methods</h4>Seventy-six HIV+ men on antiretroviral treatment completed an auditory oddball task and an inhibitory control (Simon) task while time-locked high-density EEG was acquired; 66 had usable EEG data from one or both tasks; structural MRI was available for 43. We investigated relationships between task-evoked EEG responses, cognitive ability and immunocompromise. We also explored the structural correlates of these EEG markers in the sub-sample with complete EEG and MRI data (N = 27).<h4>Results</h4>EEG activity was associated with cognitive ability at later (P300) but not earlier stages of both tasks. Only the oddball task P300 was reliably associated with HIV severity (nadir CD4). Source localization confirmed that the tasks engaged partially distinct circuits. Thalamus volume correlated with oddball task P300 amplitude, while globus pallidus volume was related to the P300 in both tasks.<h4>Interpretation</h4>This is the first study to use task-evoked EEG to identify neural correlates of individual differences in cognition in men living with well-controlled HIV infection, and to explore the structural basis of the EEG markers. We found that EEG responses evoked by the oddball task are more reliably related to cognitive performance than those evoked by the Simon task. We also provide preliminary evidence for a subcortical contribution to the effects of HIV infection severity on P300 amplitudes. These results suggest brain mechanisms and candidate biomarkers for individual differences in cognition in HIV.
format	article
author	Ana Lucia Fernandez Cruz Chien-Ming Chen Ryan Sanford D Louis Collins Marie-Josée Brouillette Nancy E Mayo Lesley K Fellows
author_facet	Ana Lucia Fernandez Cruz Chien-Ming Chen Ryan Sanford D Louis Collins Marie-Josée Brouillette Nancy E Mayo Lesley K Fellows
author_sort	Ana Lucia Fernandez Cruz
title	Multimodal neuroimaging markers of variation in cognitive ability in older HIV+ men.
title_short	Multimodal neuroimaging markers of variation in cognitive ability in older HIV+ men.
title_full	Multimodal neuroimaging markers of variation in cognitive ability in older HIV+ men.
title_fullStr	Multimodal neuroimaging markers of variation in cognitive ability in older HIV+ men.
title_full_unstemmed	Multimodal neuroimaging markers of variation in cognitive ability in older HIV+ men.
title_sort	multimodal neuroimaging markers of variation in cognitive ability in older hiv+ men.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/6adaae66ec674208a8a7712f4d619297
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Multimodal neuroimaging markers of variation in cognitive ability in older HIV+ men.

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