Maternal diet alters human milk oligosaccharide composition with implications for the milk metagenome

Abstract Human milk is the optimal nutrition source for infants, and oligosaccharides represent the third most abundant component in milk after lactose and fat. Human milk oligosaccharides (HMO) are favorable macromolecules which are, interestingly, indigestible by the infant but serve as substrates...

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Autores principales:	Maxim D. Seferovic, Mahmoud Mohammad, Ryan M. Pace, Melinda Engevik, James Versalovic, Lars Bode, Morey Haymond, Kjersti M. Aagaard
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6adbd5a8c9794016806a8a00b6fea471
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spelling	oai:doaj.org-article:6adbd5a8c9794016806a8a00b6fea4712021-12-02T13:58:10ZMaternal diet alters human milk oligosaccharide composition with implications for the milk metagenome10.1038/s41598-020-79022-62045-2322https://doaj.org/article/6adbd5a8c9794016806a8a00b6fea4712020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79022-6https://doaj.org/toc/2045-2322Abstract Human milk is the optimal nutrition source for infants, and oligosaccharides represent the third most abundant component in milk after lactose and fat. Human milk oligosaccharides (HMO) are favorable macromolecules which are, interestingly, indigestible by the infant but serve as substrates for bacteria. Hypothesizing that the maternal diet itself might influence HMO composition, we sought to directly determine the effect maternal diet on HMO and the milk bacteria. Employing a human cross-over study design, we demonstrate that distinct maternal dietary carbohydrate and energy sources preferentially alter milk concentrations of HMO, including fucosylated species. We find significant associations between the concentration of HMO-bound fucose and the abundance of fucosidase (a bacterial gene that digests fucose moieties) harbored by milk bacteria. These studies reveal a successive mechanism by which the maternal diet during lactation alters milk HMO composition, which in turn shapes the functional milk microbiome prior to infant ingestion.Maxim D. SeferovicMahmoud MohammadRyan M. PaceMelinda EngevikJames VersalovicLars BodeMorey HaymondKjersti M. AagaardNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maxim D. Seferovic Mahmoud Mohammad Ryan M. Pace Melinda Engevik James Versalovic Lars Bode Morey Haymond Kjersti M. Aagaard Maternal diet alters human milk oligosaccharide composition with implications for the milk metagenome
description	Abstract Human milk is the optimal nutrition source for infants, and oligosaccharides represent the third most abundant component in milk after lactose and fat. Human milk oligosaccharides (HMO) are favorable macromolecules which are, interestingly, indigestible by the infant but serve as substrates for bacteria. Hypothesizing that the maternal diet itself might influence HMO composition, we sought to directly determine the effect maternal diet on HMO and the milk bacteria. Employing a human cross-over study design, we demonstrate that distinct maternal dietary carbohydrate and energy sources preferentially alter milk concentrations of HMO, including fucosylated species. We find significant associations between the concentration of HMO-bound fucose and the abundance of fucosidase (a bacterial gene that digests fucose moieties) harbored by milk bacteria. These studies reveal a successive mechanism by which the maternal diet during lactation alters milk HMO composition, which in turn shapes the functional milk microbiome prior to infant ingestion.
format	article
author	Maxim D. Seferovic Mahmoud Mohammad Ryan M. Pace Melinda Engevik James Versalovic Lars Bode Morey Haymond Kjersti M. Aagaard
author_facet	Maxim D. Seferovic Mahmoud Mohammad Ryan M. Pace Melinda Engevik James Versalovic Lars Bode Morey Haymond Kjersti M. Aagaard
author_sort	Maxim D. Seferovic
title	Maternal diet alters human milk oligosaccharide composition with implications for the milk metagenome
title_short	Maternal diet alters human milk oligosaccharide composition with implications for the milk metagenome
title_full	Maternal diet alters human milk oligosaccharide composition with implications for the milk metagenome
title_fullStr	Maternal diet alters human milk oligosaccharide composition with implications for the milk metagenome
title_full_unstemmed	Maternal diet alters human milk oligosaccharide composition with implications for the milk metagenome
title_sort	maternal diet alters human milk oligosaccharide composition with implications for the milk metagenome
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/6adbd5a8c9794016806a8a00b6fea471
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Maternal diet alters human milk oligosaccharide composition with implications for the milk metagenome

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