Objective assessment of optical quality in dry eye disease using a double-pass imaging system

Larissa Gouvea,1 George Oral Waring IV,2 Ashley Brundrett,1,3 Michelle Crouse,4 Karolinne Maia Rocha1,3 1Storm Eye Institute, Medical University of South Carolina, Charleston, SC, USA; 2Waring Vision Institute, Mount Pleasant, SC, USA; 3Department of Ophthalmology, Medical University of South Caroli...

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Autores principales:	Gouvea L, Waring GO IV, Brundrett A, Crouse M, Rocha KM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Dry eye disease quality of vision tear film analysis double-pass imaging system objective scatter index ocular surface disease index fluorescein corneal staining Schirmer’s test Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/6adfeb27e236468fa457eac391086f0c
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spelling	oai:doaj.org-article:6adfeb27e236468fa457eac391086f0c2021-12-02T04:46:55ZObjective assessment of optical quality in dry eye disease using a double-pass imaging system1177-5483https://doaj.org/article/6adfeb27e236468fa457eac391086f0c2019-10-01T00:00:00Zhttps://www.dovepress.com/objective-assessment-of-optical-quality-in-dry-eye-disease-using-a-dou-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Larissa Gouvea,1 George Oral Waring IV,2 Ashley Brundrett,1,3 Michelle Crouse,4 Karolinne Maia Rocha1,3 1Storm Eye Institute, Medical University of South Carolina, Charleston, SC, USA; 2Waring Vision Institute, Mount Pleasant, SC, USA; 3Department of Ophthalmology, Medical University of South Carolina, Charleston, SC, USA; 4Department of Internal Medicine, Tulane University School of Medicine, New Orleans, LA, USACorrespondence: Larissa GouveaStorm Eye Institute, Medical University of South Carolina, 167 Ashley Avenue, Charleston, SC 29425, USAEmail gouveaalarissa@gmail.comPurpose: To assess optical quality dynamics using a double-pass (DP) system in patients with dry eye disease (DED).Methods: Seventy-six eyes with DED and 44 control subjects were enrolled in this study. Each patient underwent ocular surface evaluation including fluorescein corneal staining and Schirmer’s II test. Ocular Surface Disease Index (OSDI) questionnaire was used to assess subjective symptoms. Optical quality dynamics and tear film instability was analyzed using a DP system (HD AnalyzerTM, Visiometrics, Spain). Mean objective scatter index (OSI), maximum and minimum OSI, difference between maximum and minimum OSI (ΔOSI) were recorded with 40 consecutive scans over 20 s.Results: The DED group had pronounced impairment of optical quality compared to the control group. Mean OSI (4.29±4.07), minimum (3.22±3.51) and maximum (5.72±4.52) OSI, ΔOSI (2.50±1.96), OSDI score (36.94±16.55), and fluorescein corneal staining (0.79±0.96) were statistically significantly higher than controls (p<0.05). Schirmer’s II test was statistically significantly lower in the DED group compared to controls (10.08±7.85, 26.41±6.75, respectively; p<0.001). Three patterns of dynamic changes of OSI were proposed: ladder (continuous increase of OSI), seesaw (instability of OSI without improvement after blinking), and plateau (steady-high OSI). The ladder group showed the highest value of maximum OSI (6.93±4.13; p=0.03) and ΔOSI (3.76±2.08; p<0.001).Conclusion: DP imaging system provides an objective measurement of the visual quality in DED. Tear film instability may be assessed by dynamic changes of OSI over 20 s. In particular, the highest OSI values were observed in the ladder pattern group.Keywords: dry eye disease, quality of vision, tear film analysis, double-pass imaging system, objective scatter index, ocular surface disease index, fluorescein corneal staining, Schirmer’s testGouvea LWaring GO IVBrundrett ACrouse MRocha KMDove Medical PressarticleDry eye diseasequality of visiontear film analysisdouble-pass imaging systemobjective scatter indexocular surface disease indexfluorescein corneal stainingSchirmer’s testOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 13, Pp 1991-1996 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Dry eye disease quality of vision tear film analysis double-pass imaging system objective scatter index ocular surface disease index fluorescein corneal staining Schirmer’s test Ophthalmology RE1-994
spellingShingle	Dry eye disease quality of vision tear film analysis double-pass imaging system objective scatter index ocular surface disease index fluorescein corneal staining Schirmer’s test Ophthalmology RE1-994 Gouvea L Waring GO IV Brundrett A Crouse M Rocha KM Objective assessment of optical quality in dry eye disease using a double-pass imaging system
description	Larissa Gouvea,1 George Oral Waring IV,2 Ashley Brundrett,1,3 Michelle Crouse,4 Karolinne Maia Rocha1,3 1Storm Eye Institute, Medical University of South Carolina, Charleston, SC, USA; 2Waring Vision Institute, Mount Pleasant, SC, USA; 3Department of Ophthalmology, Medical University of South Carolina, Charleston, SC, USA; 4Department of Internal Medicine, Tulane University School of Medicine, New Orleans, LA, USACorrespondence: Larissa GouveaStorm Eye Institute, Medical University of South Carolina, 167 Ashley Avenue, Charleston, SC 29425, USAEmail gouveaalarissa@gmail.comPurpose: To assess optical quality dynamics using a double-pass (DP) system in patients with dry eye disease (DED).Methods: Seventy-six eyes with DED and 44 control subjects were enrolled in this study. Each patient underwent ocular surface evaluation including fluorescein corneal staining and Schirmer’s II test. Ocular Surface Disease Index (OSDI) questionnaire was used to assess subjective symptoms. Optical quality dynamics and tear film instability was analyzed using a DP system (HD AnalyzerTM, Visiometrics, Spain). Mean objective scatter index (OSI), maximum and minimum OSI, difference between maximum and minimum OSI (ΔOSI) were recorded with 40 consecutive scans over 20 s.Results: The DED group had pronounced impairment of optical quality compared to the control group. Mean OSI (4.29±4.07), minimum (3.22±3.51) and maximum (5.72±4.52) OSI, ΔOSI (2.50±1.96), OSDI score (36.94±16.55), and fluorescein corneal staining (0.79±0.96) were statistically significantly higher than controls (p<0.05). Schirmer’s II test was statistically significantly lower in the DED group compared to controls (10.08±7.85, 26.41±6.75, respectively; p<0.001). Three patterns of dynamic changes of OSI were proposed: ladder (continuous increase of OSI), seesaw (instability of OSI without improvement after blinking), and plateau (steady-high OSI). The ladder group showed the highest value of maximum OSI (6.93±4.13; p=0.03) and ΔOSI (3.76±2.08; p<0.001).Conclusion: DP imaging system provides an objective measurement of the visual quality in DED. Tear film instability may be assessed by dynamic changes of OSI over 20 s. In particular, the highest OSI values were observed in the ladder pattern group.Keywords: dry eye disease, quality of vision, tear film analysis, double-pass imaging system, objective scatter index, ocular surface disease index, fluorescein corneal staining, Schirmer’s test
format	article
author	Gouvea L Waring GO IV Brundrett A Crouse M Rocha KM
author_facet	Gouvea L Waring GO IV Brundrett A Crouse M Rocha KM
author_sort	Gouvea L
title	Objective assessment of optical quality in dry eye disease using a double-pass imaging system
title_short	Objective assessment of optical quality in dry eye disease using a double-pass imaging system
title_full	Objective assessment of optical quality in dry eye disease using a double-pass imaging system
title_fullStr	Objective assessment of optical quality in dry eye disease using a double-pass imaging system
title_full_unstemmed	Objective assessment of optical quality in dry eye disease using a double-pass imaging system
title_sort	objective assessment of optical quality in dry eye disease using a double-pass imaging system
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/6adfeb27e236468fa457eac391086f0c
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Objective assessment of optical quality in dry eye disease using a double-pass imaging system

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