Sputum Smear Non-conversion at the End of Intensive Phase of Tuberculosis Treatment at a Tertiary Center: A Descriptive Cross-sectional study

Introduction: Sputum non-conversion is smear positive tuberculosis despite anti-tubercular therapy. Various factors may lead to sputum non-conversion including resistance to anti-tubercular drugs, age, gender, disease severity, non-compliance, drugs unavailability etc. Little is known and studied a...

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Autores principales:	Naveen Prakash Shah, Anil Regmi, Aakash Acharya, Jwala K.C., Bidur Khatiwada, Meera Hada
Formato:	article
Lenguaje:	EN
Publicado:	Nepal Medical Association 2021
Materias:	antitubercular agents; mycobacterium tuberculosis; tuberculosis. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6ae295f4c6bd4985aa8260b7856f35f5
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spelling	oai:doaj.org-article:6ae295f4c6bd4985aa8260b7856f35f52021-11-18T19:20:03ZSputum Smear Non-conversion at the End of Intensive Phase of Tuberculosis Treatment at a Tertiary Center: A Descriptive Cross-sectional study10.31729/jnma.70200028-27151815-672Xhttps://doaj.org/article/6ae295f4c6bd4985aa8260b7856f35f52021-11-01T00:00:00Zhttp://www.jnma.com.np/jnma/index.php/jnma/article/view/7020https://doaj.org/toc/0028-2715https://doaj.org/toc/1815-672X Introduction: Sputum non-conversion is smear positive tuberculosis despite anti-tubercular therapy. Various factors may lead to sputum non-conversion including resistance to anti-tubercular drugs, age, gender, disease severity, non-compliance, drugs unavailability etc. Little is known and studied about the contribution of these individual factors. Our study sought to determine the prevalence of sputum smear non-conversion in patients at the end of intensive phase of tuberculosis treatment visiting a tertiary-level institution in Nepal. Methods: A descriptive cross-sectional study was conducted among recorded data of patients undergoing sputum Acid Fast Bacilli staining at the end of intensive phase at National Tuberculosis Control Center from April 2018 to April 2020. The study was approved by Nepal Health Research Council (Registration no: 76012020 P). The convenient sampling method was adopted. The data were analyzed using Microsoft Excel. Point estimate at 95% Confidence Interval was calculated along with frequency and proportion for binary data. Results: Our study found that out of 830 samples that were tested by Acid Fast Bacilli stain at the end of intensive phase, 40 (4.82%) (3.37-6.28 at 95% Confidence Interval) were sputum smear non-converters. The mean age of sputum non-converters was 41.25±15.543 years. Conclusions: The study shows that a significant proportion of patients remain acid-fast stain positive despite the treatment. However, the proportion is low compared to other similar studies around the globe. This study provides program managers with evidence to support the development of more tailored tuberculosis care and need to conduct more intensive studies about various factors that may lead to non-conversion. Naveen Prakash ShahAnil RegmiAakash AcharyaJwala K.C. Bidur KhatiwadaMeera HadaNepal Medical Associationarticleantitubercular agents; mycobacterium tuberculosis; tuberculosis.Medicine (General)R5-920ENJournal of Nepal Medical Association, Vol 59, Iss 243 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antitubercular agents; mycobacterium tuberculosis; tuberculosis. Medicine (General) R5-920
spellingShingle	antitubercular agents; mycobacterium tuberculosis; tuberculosis. Medicine (General) R5-920 Naveen Prakash Shah Anil Regmi Aakash Acharya Jwala K.C. Bidur Khatiwada Meera Hada Sputum Smear Non-conversion at the End of Intensive Phase of Tuberculosis Treatment at a Tertiary Center: A Descriptive Cross-sectional study
description	Introduction: Sputum non-conversion is smear positive tuberculosis despite anti-tubercular therapy. Various factors may lead to sputum non-conversion including resistance to anti-tubercular drugs, age, gender, disease severity, non-compliance, drugs unavailability etc. Little is known and studied about the contribution of these individual factors. Our study sought to determine the prevalence of sputum smear non-conversion in patients at the end of intensive phase of tuberculosis treatment visiting a tertiary-level institution in Nepal. Methods: A descriptive cross-sectional study was conducted among recorded data of patients undergoing sputum Acid Fast Bacilli staining at the end of intensive phase at National Tuberculosis Control Center from April 2018 to April 2020. The study was approved by Nepal Health Research Council (Registration no: 76012020 P). The convenient sampling method was adopted. The data were analyzed using Microsoft Excel. Point estimate at 95% Confidence Interval was calculated along with frequency and proportion for binary data. Results: Our study found that out of 830 samples that were tested by Acid Fast Bacilli stain at the end of intensive phase, 40 (4.82%) (3.37-6.28 at 95% Confidence Interval) were sputum smear non-converters. The mean age of sputum non-converters was 41.25±15.543 years. Conclusions: The study shows that a significant proportion of patients remain acid-fast stain positive despite the treatment. However, the proportion is low compared to other similar studies around the globe. This study provides program managers with evidence to support the development of more tailored tuberculosis care and need to conduct more intensive studies about various factors that may lead to non-conversion.
format	article
author	Naveen Prakash Shah Anil Regmi Aakash Acharya Jwala K.C. Bidur Khatiwada Meera Hada
author_facet	Naveen Prakash Shah Anil Regmi Aakash Acharya Jwala K.C. Bidur Khatiwada Meera Hada
author_sort	Naveen Prakash Shah
title	Sputum Smear Non-conversion at the End of Intensive Phase of Tuberculosis Treatment at a Tertiary Center: A Descriptive Cross-sectional study
title_short	Sputum Smear Non-conversion at the End of Intensive Phase of Tuberculosis Treatment at a Tertiary Center: A Descriptive Cross-sectional study
title_full	Sputum Smear Non-conversion at the End of Intensive Phase of Tuberculosis Treatment at a Tertiary Center: A Descriptive Cross-sectional study
title_fullStr	Sputum Smear Non-conversion at the End of Intensive Phase of Tuberculosis Treatment at a Tertiary Center: A Descriptive Cross-sectional study
title_full_unstemmed	Sputum Smear Non-conversion at the End of Intensive Phase of Tuberculosis Treatment at a Tertiary Center: A Descriptive Cross-sectional study
title_sort	sputum smear non-conversion at the end of intensive phase of tuberculosis treatment at a tertiary center: a descriptive cross-sectional study
publisher	Nepal Medical Association
publishDate	2021
url	https://doaj.org/article/6ae295f4c6bd4985aa8260b7856f35f5
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Sputum Smear Non-conversion at the End of Intensive Phase of Tuberculosis Treatment at a Tertiary Center: A Descriptive Cross-sectional study

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