PSPC1-interchanged interactions with PTK6 and β-catenin synergize oncogenic subcellular translocations and tumor progression

PSPC1 has a critical role in promoting EMT and metastasis. Here, the authors demonstrate that PSPC1 is the contextual determinant of the oncogenic switch of PTK6/β-catenin subcellular localizations to drive metastasis of hepatocellular carcinoma cells via a PSPC1/PTK6/β-catenin signaling.

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Autores principales:	Yaw-Dong Lang, Hsin-Yi Chen, Chun-Ming Ho, Jou-Ho Shih, En-Chi Hsu, Roger Shen, Yu-Ching Lee, Jyun-Wei Chen, Cheng-Yen Wu, Hsi-Wen Yeh, Ruey-Hwa Chen, Yuh-Shan Jou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6ae4243b31584b1da82d9909f2146f87
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spelling	oai:doaj.org-article:6ae4243b31584b1da82d9909f2146f872021-12-02T14:38:58ZPSPC1-interchanged interactions with PTK6 and β-catenin synergize oncogenic subcellular translocations and tumor progression10.1038/s41467-019-13665-62041-1723https://doaj.org/article/6ae4243b31584b1da82d9909f2146f872019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13665-6https://doaj.org/toc/2041-1723PSPC1 has a critical role in promoting EMT and metastasis. Here, the authors demonstrate that PSPC1 is the contextual determinant of the oncogenic switch of PTK6/β-catenin subcellular localizations to drive metastasis of hepatocellular carcinoma cells via a PSPC1/PTK6/β-catenin signaling.Yaw-Dong LangHsin-Yi ChenChun-Ming HoJou-Ho ShihEn-Chi HsuRoger ShenYu-Ching LeeJyun-Wei ChenCheng-Yen WuHsi-Wen YehRuey-Hwa ChenYuh-Shan JouNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yaw-Dong Lang Hsin-Yi Chen Chun-Ming Ho Jou-Ho Shih En-Chi Hsu Roger Shen Yu-Ching Lee Jyun-Wei Chen Cheng-Yen Wu Hsi-Wen Yeh Ruey-Hwa Chen Yuh-Shan Jou PSPC1-interchanged interactions with PTK6 and β-catenin synergize oncogenic subcellular translocations and tumor progression
description	PSPC1 has a critical role in promoting EMT and metastasis. Here, the authors demonstrate that PSPC1 is the contextual determinant of the oncogenic switch of PTK6/β-catenin subcellular localizations to drive metastasis of hepatocellular carcinoma cells via a PSPC1/PTK6/β-catenin signaling.
format	article
author	Yaw-Dong Lang Hsin-Yi Chen Chun-Ming Ho Jou-Ho Shih En-Chi Hsu Roger Shen Yu-Ching Lee Jyun-Wei Chen Cheng-Yen Wu Hsi-Wen Yeh Ruey-Hwa Chen Yuh-Shan Jou
author_facet	Yaw-Dong Lang Hsin-Yi Chen Chun-Ming Ho Jou-Ho Shih En-Chi Hsu Roger Shen Yu-Ching Lee Jyun-Wei Chen Cheng-Yen Wu Hsi-Wen Yeh Ruey-Hwa Chen Yuh-Shan Jou
author_sort	Yaw-Dong Lang
title	PSPC1-interchanged interactions with PTK6 and β-catenin synergize oncogenic subcellular translocations and tumor progression
title_short	PSPC1-interchanged interactions with PTK6 and β-catenin synergize oncogenic subcellular translocations and tumor progression
title_full	PSPC1-interchanged interactions with PTK6 and β-catenin synergize oncogenic subcellular translocations and tumor progression
title_fullStr	PSPC1-interchanged interactions with PTK6 and β-catenin synergize oncogenic subcellular translocations and tumor progression
title_full_unstemmed	PSPC1-interchanged interactions with PTK6 and β-catenin synergize oncogenic subcellular translocations and tumor progression
title_sort	pspc1-interchanged interactions with ptk6 and β-catenin synergize oncogenic subcellular translocations and tumor progression
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/6ae4243b31584b1da82d9909f2146f87
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PSPC1-interchanged interactions with PTK6 and β-catenin synergize oncogenic subcellular translocations and tumor progression

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