Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease

Accumulated damage to mitochondrial DNA (mtDNA) occurs during the ageing process and neurodegenerative disease. Here, the authors show that mtDNA copy number increases in an age-dependent manner in substantia nigra of healthy individuals, but not in individuals with Parkinson disease.

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Autores principales:	Christian Dölle, Irene Flønes, Gonzalo S. Nido, Hrvoje Miletic, Nelson Osuagwu, Stine Kristoffersen, Peer K. Lilleng, Jan Petter Larsen, Ole-Bjørn Tysnes, Kristoffer Haugarvoll, Laurence A. Bindoff, Charalampos Tzoulis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6ae491ca574a451db80eeeb0e7e8d4ae
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spelling	oai:doaj.org-article:6ae491ca574a451db80eeeb0e7e8d4ae2021-12-02T16:50:13ZDefective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease10.1038/ncomms135482041-1723https://doaj.org/article/6ae491ca574a451db80eeeb0e7e8d4ae2016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13548https://doaj.org/toc/2041-1723Accumulated damage to mitochondrial DNA (mtDNA) occurs during the ageing process and neurodegenerative disease. Here, the authors show that mtDNA copy number increases in an age-dependent manner in substantia nigra of healthy individuals, but not in individuals with Parkinson disease.Christian DölleIrene FlønesGonzalo S. NidoHrvoje MileticNelson OsuagwuStine KristoffersenPeer K. LillengJan Petter LarsenOle-Bjørn TysnesKristoffer HaugarvollLaurence A. BindoffCharalampos TzoulisNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christian Dölle Irene Flønes Gonzalo S. Nido Hrvoje Miletic Nelson Osuagwu Stine Kristoffersen Peer K. Lilleng Jan Petter Larsen Ole-Bjørn Tysnes Kristoffer Haugarvoll Laurence A. Bindoff Charalampos Tzoulis Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease
description	Accumulated damage to mitochondrial DNA (mtDNA) occurs during the ageing process and neurodegenerative disease. Here, the authors show that mtDNA copy number increases in an age-dependent manner in substantia nigra of healthy individuals, but not in individuals with Parkinson disease.
format	article
author	Christian Dölle Irene Flønes Gonzalo S. Nido Hrvoje Miletic Nelson Osuagwu Stine Kristoffersen Peer K. Lilleng Jan Petter Larsen Ole-Bjørn Tysnes Kristoffer Haugarvoll Laurence A. Bindoff Charalampos Tzoulis
author_facet	Christian Dölle Irene Flønes Gonzalo S. Nido Hrvoje Miletic Nelson Osuagwu Stine Kristoffersen Peer K. Lilleng Jan Petter Larsen Ole-Bjørn Tysnes Kristoffer Haugarvoll Laurence A. Bindoff Charalampos Tzoulis
author_sort	Christian Dölle
title	Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease
title_short	Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease
title_full	Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease
title_fullStr	Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease
title_full_unstemmed	Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease
title_sort	defective mitochondrial dna homeostasis in the substantia nigra in parkinson disease
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/6ae491ca574a451db80eeeb0e7e8d4ae
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Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease

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