TrkB dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant response

The precise mechanism for the sustained antidepressant action of ketamine is unclear. This study shows ketamine can promote neuronal differentiation via TrkB-ERK activation in mice and the sustained behavioral effect is attenuated when adult neurogenesis is blocked, but extended when it is enhanced.

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Autores principales:	Zhenzhong Ma, Tong Zang, Shari G. Birnbaum, Zilai Wang, Jane E. Johnson, Chun-Li Zhang, Luis F. Parada
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6ae59c97782a41d590ffaa6502413f77
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spelling	oai:doaj.org-article:6ae59c97782a41d590ffaa6502413f772021-12-02T14:40:23ZTrkB dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant response10.1038/s41467-017-01709-82041-1723https://doaj.org/article/6ae59c97782a41d590ffaa6502413f772017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01709-8https://doaj.org/toc/2041-1723The precise mechanism for the sustained antidepressant action of ketamine is unclear. This study shows ketamine can promote neuronal differentiation via TrkB-ERK activation in mice and the sustained behavioral effect is attenuated when adult neurogenesis is blocked, but extended when it is enhanced.Zhenzhong MaTong ZangShari G. BirnbaumZilai WangJane E. JohnsonChun-Li ZhangLuis F. ParadaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhenzhong Ma Tong Zang Shari G. Birnbaum Zilai Wang Jane E. Johnson Chun-Li Zhang Luis F. Parada TrkB dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant response
description	The precise mechanism for the sustained antidepressant action of ketamine is unclear. This study shows ketamine can promote neuronal differentiation via TrkB-ERK activation in mice and the sustained behavioral effect is attenuated when adult neurogenesis is blocked, but extended when it is enhanced.
format	article
author	Zhenzhong Ma Tong Zang Shari G. Birnbaum Zilai Wang Jane E. Johnson Chun-Li Zhang Luis F. Parada
author_facet	Zhenzhong Ma Tong Zang Shari G. Birnbaum Zilai Wang Jane E. Johnson Chun-Li Zhang Luis F. Parada
author_sort	Zhenzhong Ma
title	TrkB dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant response
title_short	TrkB dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant response
title_full	TrkB dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant response
title_fullStr	TrkB dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant response
title_full_unstemmed	TrkB dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant response
title_sort	trkb dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant response
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6ae59c97782a41d590ffaa6502413f77
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TrkB dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant response

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