Modulation of Peptide Based Nano-Assemblies with Electric and Magnetic Fields

Abstract Peptide based nano-assemblies with their self-organizing ability has shown lot of promise due to their high degree of thermal and chemical stability, for biomaterial fabrication. Developing an effective way to control the organization of these structures is important for fabricating applica...

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Autores principales:	Gaurav Pandey, Jahnu Saikia, Sajitha Sasidharan, Deep C. Joshi, Subhash Thota, Harshal B. Nemade, Nitin Chaudhary, Vibin Ramakrishnan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6ae6bce903864eb4918959ec798bef17
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spelling	oai:doaj.org-article:6ae6bce903864eb4918959ec798bef172021-12-02T15:05:00ZModulation of Peptide Based Nano-Assemblies with Electric and Magnetic Fields10.1038/s41598-017-02609-z2045-2322https://doaj.org/article/6ae6bce903864eb4918959ec798bef172017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02609-zhttps://doaj.org/toc/2045-2322Abstract Peptide based nano-assemblies with their self-organizing ability has shown lot of promise due to their high degree of thermal and chemical stability, for biomaterial fabrication. Developing an effective way to control the organization of these structures is important for fabricating application-oriented materials at the molecular level. The present study reports the impact of electric and magnetic field-mediated perturbation of the self-assembly phenomenon, upon the chemical and structural properties of diphenylalanine assembly. Our studies show that, electric field effectively arrests aggregation and self-assembly formation, while the molecule is allowed to anneal in the presence of applied electric fields of varying magnitudes, both AC and DC. The electric field exposure also modulated the morphology of the self-assembled structures without affecting the overall chemical constitution of the material. Our results on the modulatory effect of the electric field are in good agreement with theoretical studies based on molecular dynamics reported earlier on amyloid forming molecular systems. Furthermore, we demonstrate that the self-assemblies formed post electric-field exposure, showed difference in their crystal habit. Modulation of nano-level architecture of peptide based model systems with external stimulus, points to a potentially rewarding strategy to re-work proven nano-materials to expand their application spectrum.Gaurav PandeyJahnu SaikiaSajitha SasidharanDeep C. JoshiSubhash ThotaHarshal B. NemadeNitin ChaudharyVibin RamakrishnanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gaurav Pandey Jahnu Saikia Sajitha Sasidharan Deep C. Joshi Subhash Thota Harshal B. Nemade Nitin Chaudhary Vibin Ramakrishnan Modulation of Peptide Based Nano-Assemblies with Electric and Magnetic Fields
description	Abstract Peptide based nano-assemblies with their self-organizing ability has shown lot of promise due to their high degree of thermal and chemical stability, for biomaterial fabrication. Developing an effective way to control the organization of these structures is important for fabricating application-oriented materials at the molecular level. The present study reports the impact of electric and magnetic field-mediated perturbation of the self-assembly phenomenon, upon the chemical and structural properties of diphenylalanine assembly. Our studies show that, electric field effectively arrests aggregation and self-assembly formation, while the molecule is allowed to anneal in the presence of applied electric fields of varying magnitudes, both AC and DC. The electric field exposure also modulated the morphology of the self-assembled structures without affecting the overall chemical constitution of the material. Our results on the modulatory effect of the electric field are in good agreement with theoretical studies based on molecular dynamics reported earlier on amyloid forming molecular systems. Furthermore, we demonstrate that the self-assemblies formed post electric-field exposure, showed difference in their crystal habit. Modulation of nano-level architecture of peptide based model systems with external stimulus, points to a potentially rewarding strategy to re-work proven nano-materials to expand their application spectrum.
format	article
author	Gaurav Pandey Jahnu Saikia Sajitha Sasidharan Deep C. Joshi Subhash Thota Harshal B. Nemade Nitin Chaudhary Vibin Ramakrishnan
author_facet	Gaurav Pandey Jahnu Saikia Sajitha Sasidharan Deep C. Joshi Subhash Thota Harshal B. Nemade Nitin Chaudhary Vibin Ramakrishnan
author_sort	Gaurav Pandey
title	Modulation of Peptide Based Nano-Assemblies with Electric and Magnetic Fields
title_short	Modulation of Peptide Based Nano-Assemblies with Electric and Magnetic Fields
title_full	Modulation of Peptide Based Nano-Assemblies with Electric and Magnetic Fields
title_fullStr	Modulation of Peptide Based Nano-Assemblies with Electric and Magnetic Fields
title_full_unstemmed	Modulation of Peptide Based Nano-Assemblies with Electric and Magnetic Fields
title_sort	modulation of peptide based nano-assemblies with electric and magnetic fields
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6ae6bce903864eb4918959ec798bef17
work_keys_str_mv	AT gauravpandey modulationofpeptidebasednanoassemblieswithelectricandmagneticfields AT jahnusaikia modulationofpeptidebasednanoassemblieswithelectricandmagneticfields AT sajithasasidharan modulationofpeptidebasednanoassemblieswithelectricandmagneticfields AT deepcjoshi modulationofpeptidebasednanoassemblieswithelectricandmagneticfields AT subhashthota modulationofpeptidebasednanoassemblieswithelectricandmagneticfields AT harshalbnemade modulationofpeptidebasednanoassemblieswithelectricandmagneticfields AT nitinchaudhary modulationofpeptidebasednanoassemblieswithelectricandmagneticfields AT vibinramakrishnan modulationofpeptidebasednanoassemblieswithelectricandmagneticfields
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Modulation of Peptide Based Nano-Assemblies with Electric and Magnetic Fields

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