Concentration and avidity of antibodies to different circumsporozoite epitopes correlate with RTS,S/AS01E malaria vaccine efficacy

Concentration and avidity of antibodies to different circumsporozoite epitopes correlate with RTS,S/AS01E malaria vaccine efficacy

RTS,S/AS01E has been tested in a phase 3 malaria vaccine trial and has shown partial efficacy in children and infants. Here, the authors analyze IgG concentration and avidity to CSP in ~1000 participants and show that IgG avidity to the C-terminus of CSP is significantly associated with vaccine-medi...

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Auteurs principaux: Carlota Dobaño, Hèctor Sanz, Hermann Sorgho, David Dosoo, Maximilian Mpina, Itziar Ubillos, Ruth Aguilar, Tom Ford, Núria Díez-Padrisa, Nana Aba Williams, Aintzane Ayestaran, Ousmane Traore, Augusto J. Nhabomba, Chenjerai Jairoce, John Waitumbi, Selidji Todagbe Agnandji, Simon Kariuki, Salim Abdulla, John J. Aponte, Benjamin Mordmüller, Kwaku Poku Asante, Seth Owusu-Agyei, Halidou Tinto, Joseph J. Campo, Gemma Moncunill, Ben Gyan, Clarissa Valim, Claudia Daubenberger
Format: article
Langue:EN
Publié: Nature Portfolio 2019
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Science
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Accès en ligne:https://doaj.org/article/6ae81e5ff5b64b178bd0004db55bf7a3
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Résumé:RTS,S/AS01E has been tested in a phase 3 malaria vaccine trial and has shown partial efficacy in children and infants. Here, the authors analyze IgG concentration and avidity to CSP in ~1000 participants and show that IgG avidity to the C-terminus of CSP is significantly associated with vaccine-mediated protection.

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