Concentration and avidity of antibodies to different circumsporozoite epitopes correlate with RTS,S/AS01E malaria vaccine efficacy
RTS,S/AS01E has been tested in a phase 3 malaria vaccine trial and has shown partial efficacy in children and infants. Here, the authors analyze IgG concentration and avidity to CSP in ~1000 participants and show that IgG avidity to the C-terminus of CSP is significantly associated with vaccine-medi...
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Nature Portfolio
2019
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oai:doaj.org-article:6ae81e5ff5b64b178bd0004db55bf7a32021-12-02T16:50:58ZConcentration and avidity of antibodies to different circumsporozoite epitopes correlate with RTS,S/AS01E malaria vaccine efficacy10.1038/s41467-019-10195-z2041-1723https://doaj.org/article/6ae81e5ff5b64b178bd0004db55bf7a32019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10195-zhttps://doaj.org/toc/2041-1723RTS,S/AS01E has been tested in a phase 3 malaria vaccine trial and has shown partial efficacy in children and infants. Here, the authors analyze IgG concentration and avidity to CSP in ~1000 participants and show that IgG avidity to the C-terminus of CSP is significantly associated with vaccine-mediated protection.Carlota DobañoHèctor SanzHermann SorghoDavid DosooMaximilian MpinaItziar UbillosRuth AguilarTom FordNúria Díez-PadrisaNana Aba WilliamsAintzane AyestaranOusmane TraoreAugusto J. NhabombaChenjerai JairoceJohn WaitumbiSelidji Todagbe AgnandjiSimon KariukiSalim AbdullaJohn J. AponteBenjamin MordmüllerKwaku Poku AsanteSeth Owusu-AgyeiHalidou TintoJoseph J. CampoGemma MoncunillBen GyanClarissa ValimClaudia DaubenbergerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Science Q |
| spellingShingle |
Science Q Carlota Dobaño Hèctor Sanz Hermann Sorgho David Dosoo Maximilian Mpina Itziar Ubillos Ruth Aguilar Tom Ford Núria Díez-Padrisa Nana Aba Williams Aintzane Ayestaran Ousmane Traore Augusto J. Nhabomba Chenjerai Jairoce John Waitumbi Selidji Todagbe Agnandji Simon Kariuki Salim Abdulla John J. Aponte Benjamin Mordmüller Kwaku Poku Asante Seth Owusu-Agyei Halidou Tinto Joseph J. Campo Gemma Moncunill Ben Gyan Clarissa Valim Claudia Daubenberger Concentration and avidity of antibodies to different circumsporozoite epitopes correlate with RTS,S/AS01E malaria vaccine efficacy |
| description |
RTS,S/AS01E has been tested in a phase 3 malaria vaccine trial and has shown partial efficacy in children and infants. Here, the authors analyze IgG concentration and avidity to CSP in ~1000 participants and show that IgG avidity to the C-terminus of CSP is significantly associated with vaccine-mediated protection. |
| format |
article |
| author |
Carlota Dobaño Hèctor Sanz Hermann Sorgho David Dosoo Maximilian Mpina Itziar Ubillos Ruth Aguilar Tom Ford Núria Díez-Padrisa Nana Aba Williams Aintzane Ayestaran Ousmane Traore Augusto J. Nhabomba Chenjerai Jairoce John Waitumbi Selidji Todagbe Agnandji Simon Kariuki Salim Abdulla John J. Aponte Benjamin Mordmüller Kwaku Poku Asante Seth Owusu-Agyei Halidou Tinto Joseph J. Campo Gemma Moncunill Ben Gyan Clarissa Valim Claudia Daubenberger |
| author_facet |
Carlota Dobaño Hèctor Sanz Hermann Sorgho David Dosoo Maximilian Mpina Itziar Ubillos Ruth Aguilar Tom Ford Núria Díez-Padrisa Nana Aba Williams Aintzane Ayestaran Ousmane Traore Augusto J. Nhabomba Chenjerai Jairoce John Waitumbi Selidji Todagbe Agnandji Simon Kariuki Salim Abdulla John J. Aponte Benjamin Mordmüller Kwaku Poku Asante Seth Owusu-Agyei Halidou Tinto Joseph J. Campo Gemma Moncunill Ben Gyan Clarissa Valim Claudia Daubenberger |
| author_sort |
Carlota Dobaño |
| title |
Concentration and avidity of antibodies to different circumsporozoite epitopes correlate with RTS,S/AS01E malaria vaccine efficacy |
| title_short |
Concentration and avidity of antibodies to different circumsporozoite epitopes correlate with RTS,S/AS01E malaria vaccine efficacy |
| title_full |
Concentration and avidity of antibodies to different circumsporozoite epitopes correlate with RTS,S/AS01E malaria vaccine efficacy |
| title_fullStr |
Concentration and avidity of antibodies to different circumsporozoite epitopes correlate with RTS,S/AS01E malaria vaccine efficacy |
| title_full_unstemmed |
Concentration and avidity of antibodies to different circumsporozoite epitopes correlate with RTS,S/AS01E malaria vaccine efficacy |
| title_sort |
concentration and avidity of antibodies to different circumsporozoite epitopes correlate with rts,s/as01e malaria vaccine efficacy |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/6ae81e5ff5b64b178bd0004db55bf7a3 |
| work_keys_str_mv |
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