Recognition of membrane-bound fusion-peptide/MPER complexes by the HIV-1 neutralizing 2F5 antibody: implications for anti-2F5 immunogenicity.

The membrane proximal external region (MPER) of the fusogenic HIV-1 glycoprotein-41 harbors the epitope sequence recognized by 2F5, a broadly neutralizing antibody isolated from an infected individual. Structural mimicry of the conserved MPER 2F5 epitope constitutes a pursued goal in the field of an...

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Autores principales: Nerea Huarte, Aitziber Araujo, Rocio Arranz, Maier Lorizate, Heribert Quendler, Renate Kunert, José M Valpuesta, José L Nieva
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/6aea9a07231740fb94f15b5f23f27c2e
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