Introducing a modern chemotherapeutic drug formulated by iron nanoparticles for the treatment of human lung cancer

In the present study, iron nanoparticles were green-synthesized using the aqueous extract of Alhagi maurorum leaf aqueous extract. The synthesized FeNPs were characterized by analytical techniques including EDX, FE-SEM, XRD, UV–vis and FT-IR. The anti-human lung cancer activity of FeNPs was evaluate...

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Autores principales:	Junfeng Bai, Xin Gongsun, Liangliang Xue, Mohammad Mahdi Zangeneh
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	iron nanoparticles green synthesis chemotherapeutic drug anti-human lung cancer antioxidant cytotoxicity Materials of engineering and construction. Mechanics of materials TA401-492 Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/6aec911016944d47bb7431ffddbdee09
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spelling	oai:doaj.org-article:6aec911016944d47bb7431ffddbdee092021-11-26T11:19:48ZIntroducing a modern chemotherapeutic drug formulated by iron nanoparticles for the treatment of human lung cancer1745-80801745-809910.1080/17458080.2021.1998460https://doaj.org/article/6aec911016944d47bb7431ffddbdee092021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/17458080.2021.1998460https://doaj.org/toc/1745-8080https://doaj.org/toc/1745-8099In the present study, iron nanoparticles were green-synthesized using the aqueous extract of Alhagi maurorum leaf aqueous extract. The synthesized FeNPs were characterized by analytical techniques including EDX, FE-SEM, XRD, UV–vis and FT-IR. The anti-human lung cancer activity of FeNPs was evaluated using MTT assay. The nanoparticles were formed in a spherical shape in the average size of 60.11 nm. In the cellular and molecular part of the recent study, the treated cells with FeNPs were assessed by MTT assay for 48 h about the cytotoxicity and anti-human lung cancer properties on normal (HUVEC) and lung cancer cell lines i.e. HLC-1 and PC-14. The viability of malignant lung cell line reduced dose-dependently in the presence of FeNPs. The IC50 of FeNPs was 195 and 181 µg/mL against HLC-1 and PC-14 cell lines, respectively. In the antioxidant test, the IC50 of FeNPs and BHT against DPPH free radicals was 214 and 62 µg/mL, respectively. After the clinical study, iron nanoparticles containing A. maurorum leaf aqueous extract may be used to formulate a new chemotherapeutic drug or supplement to treat several types of human lung cancer.Junfeng BaiXin GongsunLiangliang XueMohammad Mahdi ZangenehTaylor & Francis Grouparticleiron nanoparticlesgreen synthesischemotherapeutic druganti-human lung cancerantioxidantcytotoxicityMaterials of engineering and construction. Mechanics of materialsTA401-492Chemical technologyTP1-1185ENJournal of Experimental Nanoscience, Vol 16, Iss 1, Pp 398-410 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	iron nanoparticles green synthesis chemotherapeutic drug anti-human lung cancer antioxidant cytotoxicity Materials of engineering and construction. Mechanics of materials TA401-492 Chemical technology TP1-1185
spellingShingle	iron nanoparticles green synthesis chemotherapeutic drug anti-human lung cancer antioxidant cytotoxicity Materials of engineering and construction. Mechanics of materials TA401-492 Chemical technology TP1-1185 Junfeng Bai Xin Gongsun Liangliang Xue Mohammad Mahdi Zangeneh Introducing a modern chemotherapeutic drug formulated by iron nanoparticles for the treatment of human lung cancer
description	In the present study, iron nanoparticles were green-synthesized using the aqueous extract of Alhagi maurorum leaf aqueous extract. The synthesized FeNPs were characterized by analytical techniques including EDX, FE-SEM, XRD, UV–vis and FT-IR. The anti-human lung cancer activity of FeNPs was evaluated using MTT assay. The nanoparticles were formed in a spherical shape in the average size of 60.11 nm. In the cellular and molecular part of the recent study, the treated cells with FeNPs were assessed by MTT assay for 48 h about the cytotoxicity and anti-human lung cancer properties on normal (HUVEC) and lung cancer cell lines i.e. HLC-1 and PC-14. The viability of malignant lung cell line reduced dose-dependently in the presence of FeNPs. The IC50 of FeNPs was 195 and 181 µg/mL against HLC-1 and PC-14 cell lines, respectively. In the antioxidant test, the IC50 of FeNPs and BHT against DPPH free radicals was 214 and 62 µg/mL, respectively. After the clinical study, iron nanoparticles containing A. maurorum leaf aqueous extract may be used to formulate a new chemotherapeutic drug or supplement to treat several types of human lung cancer.
format	article
author	Junfeng Bai Xin Gongsun Liangliang Xue Mohammad Mahdi Zangeneh
author_facet	Junfeng Bai Xin Gongsun Liangliang Xue Mohammad Mahdi Zangeneh
author_sort	Junfeng Bai
title	Introducing a modern chemotherapeutic drug formulated by iron nanoparticles for the treatment of human lung cancer
title_short	Introducing a modern chemotherapeutic drug formulated by iron nanoparticles for the treatment of human lung cancer
title_full	Introducing a modern chemotherapeutic drug formulated by iron nanoparticles for the treatment of human lung cancer
title_fullStr	Introducing a modern chemotherapeutic drug formulated by iron nanoparticles for the treatment of human lung cancer
title_full_unstemmed	Introducing a modern chemotherapeutic drug formulated by iron nanoparticles for the treatment of human lung cancer
title_sort	introducing a modern chemotherapeutic drug formulated by iron nanoparticles for the treatment of human lung cancer
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/6aec911016944d47bb7431ffddbdee09
work_keys_str_mv	AT junfengbai introducingamodernchemotherapeuticdrugformulatedbyironnanoparticlesforthetreatmentofhumanlungcancer AT xingongsun introducingamodernchemotherapeuticdrugformulatedbyironnanoparticlesforthetreatmentofhumanlungcancer AT liangliangxue introducingamodernchemotherapeuticdrugformulatedbyironnanoparticlesforthetreatmentofhumanlungcancer AT mohammadmahdizangeneh introducingamodernchemotherapeuticdrugformulatedbyironnanoparticlesforthetreatmentofhumanlungcancer
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Introducing a modern chemotherapeutic drug formulated by iron nanoparticles for the treatment of human lung cancer

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