Ancient dispersal of the human fungal pathogen Cryptococcus gattii from the Amazon rainforest.

Over the past two decades, several fungal outbreaks have occurred, including the high-profile 'Vancouver Island' and 'Pacific Northwest' outbreaks, caused by Cryptococcus gattii, which has affected hundreds of otherwise healthy humans and animals. Over the same time period, C. ga...

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Autores principales: Ferry Hagen, Paulo C Ceresini, Itzhack Polacheck, Hansong Ma, Filip van Nieuwerburgh, Toni Gabaldón, Sarah Kagan, E Rhiannon Pursall, Hans L Hoogveld, Leo J J van Iersel, Gunnar W Klau, Steven M Kelk, Leen Stougie, Karen H Bartlett, Kerstin Voelz, Leszek P Pryszcz, Elizabeth Castañeda, Marcia Lazera, Wieland Meyer, Dieter Deforce, Jacques F Meis, Robin C May, Corné H W Klaassen, Teun Boekhout
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Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/6af1b4316421490ebbf69de995a5bb95
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spelling oai:doaj.org-article:6af1b4316421490ebbf69de995a5bb952021-11-18T09:00:54ZAncient dispersal of the human fungal pathogen Cryptococcus gattii from the Amazon rainforest.1932-620310.1371/journal.pone.0071148https://doaj.org/article/6af1b4316421490ebbf69de995a5bb952013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23940707/?tool=EBIhttps://doaj.org/toc/1932-6203Over the past two decades, several fungal outbreaks have occurred, including the high-profile 'Vancouver Island' and 'Pacific Northwest' outbreaks, caused by Cryptococcus gattii, which has affected hundreds of otherwise healthy humans and animals. Over the same time period, C. gattii was the cause of several additional case clusters at localities outside of the tropical and subtropical climate zones where the species normally occurs. In every case, the causative agent belongs to a previously rare genotype of C. gattii called AFLP6/VGII, but the origin of the outbreak clades remains enigmatic. Here we used phylogenetic and recombination analyses, based on AFLP and multiple MLST datasets, and coalescence gene genealogy to demonstrate that these outbreaks have arisen from a highly-recombining C. gattii population in the native rainforest of Northern Brazil. Thus the modern virulent C. gattii AFLP6/VGII outbreak lineages derived from mating events in South America and then dispersed to temperate regions where they cause serious infections in humans and animals.Ferry HagenPaulo C CeresiniItzhack PolacheckHansong MaFilip van NieuwerburghToni GabaldónSarah KaganE Rhiannon PursallHans L HoogveldLeo J J van IerselGunnar W KlauSteven M KelkLeen StougieKaren H BartlettKerstin VoelzLeszek P PryszczElizabeth CastañedaMarcia LazeraWieland MeyerDieter DeforceJacques F MeisRobin C MayCorné H W KlaassenTeun BoekhoutPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 8, p e71148 (2013)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Ferry Hagen
Paulo C Ceresini
Itzhack Polacheck
Hansong Ma
Filip van Nieuwerburgh
Toni Gabaldón
Sarah Kagan
E Rhiannon Pursall
Hans L Hoogveld
Leo J J van Iersel
Gunnar W Klau
Steven M Kelk
Leen Stougie
Karen H Bartlett
Kerstin Voelz
Leszek P Pryszcz
Elizabeth Castañeda
Marcia Lazera
Wieland Meyer
Dieter Deforce
Jacques F Meis
Robin C May
Corné H W Klaassen
Teun Boekhout
Ancient dispersal of the human fungal pathogen Cryptococcus gattii from the Amazon rainforest.
description Over the past two decades, several fungal outbreaks have occurred, including the high-profile 'Vancouver Island' and 'Pacific Northwest' outbreaks, caused by Cryptococcus gattii, which has affected hundreds of otherwise healthy humans and animals. Over the same time period, C. gattii was the cause of several additional case clusters at localities outside of the tropical and subtropical climate zones where the species normally occurs. In every case, the causative agent belongs to a previously rare genotype of C. gattii called AFLP6/VGII, but the origin of the outbreak clades remains enigmatic. Here we used phylogenetic and recombination analyses, based on AFLP and multiple MLST datasets, and coalescence gene genealogy to demonstrate that these outbreaks have arisen from a highly-recombining C. gattii population in the native rainforest of Northern Brazil. Thus the modern virulent C. gattii AFLP6/VGII outbreak lineages derived from mating events in South America and then dispersed to temperate regions where they cause serious infections in humans and animals.
format article
author Ferry Hagen
Paulo C Ceresini
Itzhack Polacheck
Hansong Ma
Filip van Nieuwerburgh
Toni Gabaldón
Sarah Kagan
E Rhiannon Pursall
Hans L Hoogveld
Leo J J van Iersel
Gunnar W Klau
Steven M Kelk
Leen Stougie
Karen H Bartlett
Kerstin Voelz
Leszek P Pryszcz
Elizabeth Castañeda
Marcia Lazera
Wieland Meyer
Dieter Deforce
Jacques F Meis
Robin C May
Corné H W Klaassen
Teun Boekhout
author_facet Ferry Hagen
Paulo C Ceresini
Itzhack Polacheck
Hansong Ma
Filip van Nieuwerburgh
Toni Gabaldón
Sarah Kagan
E Rhiannon Pursall
Hans L Hoogveld
Leo J J van Iersel
Gunnar W Klau
Steven M Kelk
Leen Stougie
Karen H Bartlett
Kerstin Voelz
Leszek P Pryszcz
Elizabeth Castañeda
Marcia Lazera
Wieland Meyer
Dieter Deforce
Jacques F Meis
Robin C May
Corné H W Klaassen
Teun Boekhout
author_sort Ferry Hagen
title Ancient dispersal of the human fungal pathogen Cryptococcus gattii from the Amazon rainforest.
title_short Ancient dispersal of the human fungal pathogen Cryptococcus gattii from the Amazon rainforest.
title_full Ancient dispersal of the human fungal pathogen Cryptococcus gattii from the Amazon rainforest.
title_fullStr Ancient dispersal of the human fungal pathogen Cryptococcus gattii from the Amazon rainforest.
title_full_unstemmed Ancient dispersal of the human fungal pathogen Cryptococcus gattii from the Amazon rainforest.
title_sort ancient dispersal of the human fungal pathogen cryptococcus gattii from the amazon rainforest.
publisher Public Library of Science (PLoS)
publishDate 2013
url https://doaj.org/article/6af1b4316421490ebbf69de995a5bb95
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