Continuous flow production of concentrated hyperpolarized xenon gas from a dilute xenon gas mixture by buffer gas condensation

Abstract We present a new method for the continuous flow production of concentrated hyperpolarized xenon-129 (HP 129Xe) gas from a dilute xenon (Xe) gas mixture with high nuclear spin polarization. A low vapor pressure (i.e., high boiling-point) gas was introduced as an alternative to molecular nitr...

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Autores principales:	Hirohiko Imai, Hironobu Yoshimura, Atsuomi Kimura, Hideaki Fujiwara
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6af611a7841647dea03fafe9586ca693
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spelling	oai:doaj.org-article:6af611a7841647dea03fafe9586ca6932021-12-02T12:32:15ZContinuous flow production of concentrated hyperpolarized xenon gas from a dilute xenon gas mixture by buffer gas condensation10.1038/s41598-017-07695-72045-2322https://doaj.org/article/6af611a7841647dea03fafe9586ca6932017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07695-7https://doaj.org/toc/2045-2322Abstract We present a new method for the continuous flow production of concentrated hyperpolarized xenon-129 (HP 129Xe) gas from a dilute xenon (Xe) gas mixture with high nuclear spin polarization. A low vapor pressure (i.e., high boiling-point) gas was introduced as an alternative to molecular nitrogen (N2), which is the conventional quenching gas for generating HP 129Xe via Rb-Xe spin-exchange optical-pumping (SEOP). In contrast to the generally used method of extraction by freezing Xe after the SEOP process, the quenching gas separated as a liquid at moderately low temperature so that Xe was maintained in its gaseous state, allowing the continuous delivery of highly polarized concentrated Xe gas. We selected isobutene as the candidate quenching gas and our method was demonstrated experimentally while comparing its performance with N2. Isobutene could be liquefied and removed from the Xe gas mixture using a cold trap, and the concentrated HP 129Xe gas exhibited a significantly enhanced nuclear magnetic resonance (NMR) signal. Although the system requires further optimization depending on the intended purpose, our approach presented here could provide a simple means for performing NMR or magnetic resonance imaging (MRI) measurements continuously using HP 129Xe with improved sensitivity.Hirohiko ImaiHironobu YoshimuraAtsuomi KimuraHideaki FujiwaraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hirohiko Imai Hironobu Yoshimura Atsuomi Kimura Hideaki Fujiwara Continuous flow production of concentrated hyperpolarized xenon gas from a dilute xenon gas mixture by buffer gas condensation
description	Abstract We present a new method for the continuous flow production of concentrated hyperpolarized xenon-129 (HP 129Xe) gas from a dilute xenon (Xe) gas mixture with high nuclear spin polarization. A low vapor pressure (i.e., high boiling-point) gas was introduced as an alternative to molecular nitrogen (N2), which is the conventional quenching gas for generating HP 129Xe via Rb-Xe spin-exchange optical-pumping (SEOP). In contrast to the generally used method of extraction by freezing Xe after the SEOP process, the quenching gas separated as a liquid at moderately low temperature so that Xe was maintained in its gaseous state, allowing the continuous delivery of highly polarized concentrated Xe gas. We selected isobutene as the candidate quenching gas and our method was demonstrated experimentally while comparing its performance with N2. Isobutene could be liquefied and removed from the Xe gas mixture using a cold trap, and the concentrated HP 129Xe gas exhibited a significantly enhanced nuclear magnetic resonance (NMR) signal. Although the system requires further optimization depending on the intended purpose, our approach presented here could provide a simple means for performing NMR or magnetic resonance imaging (MRI) measurements continuously using HP 129Xe with improved sensitivity.
format	article
author	Hirohiko Imai Hironobu Yoshimura Atsuomi Kimura Hideaki Fujiwara
author_facet	Hirohiko Imai Hironobu Yoshimura Atsuomi Kimura Hideaki Fujiwara
author_sort	Hirohiko Imai
title	Continuous flow production of concentrated hyperpolarized xenon gas from a dilute xenon gas mixture by buffer gas condensation
title_short	Continuous flow production of concentrated hyperpolarized xenon gas from a dilute xenon gas mixture by buffer gas condensation
title_full	Continuous flow production of concentrated hyperpolarized xenon gas from a dilute xenon gas mixture by buffer gas condensation
title_fullStr	Continuous flow production of concentrated hyperpolarized xenon gas from a dilute xenon gas mixture by buffer gas condensation
title_full_unstemmed	Continuous flow production of concentrated hyperpolarized xenon gas from a dilute xenon gas mixture by buffer gas condensation
title_sort	continuous flow production of concentrated hyperpolarized xenon gas from a dilute xenon gas mixture by buffer gas condensation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6af611a7841647dea03fafe9586ca693
work_keys_str_mv	AT hirohikoimai continuousflowproductionofconcentratedhyperpolarizedxenongasfromadilutexenongasmixturebybuffergascondensation AT hironobuyoshimura continuousflowproductionofconcentratedhyperpolarizedxenongasfromadilutexenongasmixturebybuffergascondensation AT atsuomikimura continuousflowproductionofconcentratedhyperpolarizedxenongasfromadilutexenongasmixturebybuffergascondensation AT hideakifujiwara continuousflowproductionofconcentratedhyperpolarizedxenongasfromadilutexenongasmixturebybuffergascondensation
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Continuous flow production of concentrated hyperpolarized xenon gas from a dilute xenon gas mixture by buffer gas condensation

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