A novel role for bone marrow-derived cells to recover damaged keratinocytes from radiation-induced injury

Abstract Exposure to moderate doses of ionizing radiation (IR), which is sufficient for causing skin injury, can occur during radiation therapy as well as in radiation accidents. Radiation-induced skin injury occasionally recovers, although its underlying mechanism remains unclear. Moderate-dose IR...

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Autores principales:	Junko Okano, Yuki Nakae, Takahiko Nakagawa, Miwako Katagi, Tomoya Terashima, Daisuke Nagakubo, Takashi Nakayama, Osamu Yoshie, Yoshihisa Suzuki, Hideto Kojima
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6af682acd4a34395939e1f2e7783ce9b
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spelling	oai:doaj.org-article:6af682acd4a34395939e1f2e7783ce9b2021-12-02T13:34:57ZA novel role for bone marrow-derived cells to recover damaged keratinocytes from radiation-induced injury10.1038/s41598-021-84818-12045-2322https://doaj.org/article/6af682acd4a34395939e1f2e7783ce9b2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84818-1https://doaj.org/toc/2045-2322Abstract Exposure to moderate doses of ionizing radiation (IR), which is sufficient for causing skin injury, can occur during radiation therapy as well as in radiation accidents. Radiation-induced skin injury occasionally recovers, although its underlying mechanism remains unclear. Moderate-dose IR is frequently utilized for bone marrow transplantation in mice; therefore, this mouse model can help understand the mechanism. We had previously reported that bone marrow-derived cells (BMDCs) migrate to the epidermis-dermis junction in response to IR, although their role remains unknown. Here, we investigated the role of BMDCs in radiation-induced skin injury in BMT mice and observed that BMDCs contributed to skin recovery after IR-induced barrier dysfunction. One of the important mechanisms involved the action of CCL17 secreted by BMDCs on irradiated basal cells, leading to accelerated proliferation and recovery of apoptosis caused by IR. Our findings suggest that BMDCs are key players in IR-induced skin injury recovery.Junko OkanoYuki NakaeTakahiko NakagawaMiwako KatagiTomoya TerashimaDaisuke NagakuboTakashi NakayamaOsamu YoshieYoshihisa SuzukiHideto KojimaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Junko Okano Yuki Nakae Takahiko Nakagawa Miwako Katagi Tomoya Terashima Daisuke Nagakubo Takashi Nakayama Osamu Yoshie Yoshihisa Suzuki Hideto Kojima A novel role for bone marrow-derived cells to recover damaged keratinocytes from radiation-induced injury
description	Abstract Exposure to moderate doses of ionizing radiation (IR), which is sufficient for causing skin injury, can occur during radiation therapy as well as in radiation accidents. Radiation-induced skin injury occasionally recovers, although its underlying mechanism remains unclear. Moderate-dose IR is frequently utilized for bone marrow transplantation in mice; therefore, this mouse model can help understand the mechanism. We had previously reported that bone marrow-derived cells (BMDCs) migrate to the epidermis-dermis junction in response to IR, although their role remains unknown. Here, we investigated the role of BMDCs in radiation-induced skin injury in BMT mice and observed that BMDCs contributed to skin recovery after IR-induced barrier dysfunction. One of the important mechanisms involved the action of CCL17 secreted by BMDCs on irradiated basal cells, leading to accelerated proliferation and recovery of apoptosis caused by IR. Our findings suggest that BMDCs are key players in IR-induced skin injury recovery.
format	article
author	Junko Okano Yuki Nakae Takahiko Nakagawa Miwako Katagi Tomoya Terashima Daisuke Nagakubo Takashi Nakayama Osamu Yoshie Yoshihisa Suzuki Hideto Kojima
author_facet	Junko Okano Yuki Nakae Takahiko Nakagawa Miwako Katagi Tomoya Terashima Daisuke Nagakubo Takashi Nakayama Osamu Yoshie Yoshihisa Suzuki Hideto Kojima
author_sort	Junko Okano
title	A novel role for bone marrow-derived cells to recover damaged keratinocytes from radiation-induced injury
title_short	A novel role for bone marrow-derived cells to recover damaged keratinocytes from radiation-induced injury
title_full	A novel role for bone marrow-derived cells to recover damaged keratinocytes from radiation-induced injury
title_fullStr	A novel role for bone marrow-derived cells to recover damaged keratinocytes from radiation-induced injury
title_full_unstemmed	A novel role for bone marrow-derived cells to recover damaged keratinocytes from radiation-induced injury
title_sort	novel role for bone marrow-derived cells to recover damaged keratinocytes from radiation-induced injury
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6af682acd4a34395939e1f2e7783ce9b
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A novel role for bone marrow-derived cells to recover damaged keratinocytes from radiation-induced injury

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