Multi-region sequencing unveils novel actionable targets and spatial heterogeneity in esophageal squamous cell carcinoma

Esophageal squamous cell carcinoma (ESCC) is highly prevalent in China. Here, the authors carry out multi-region sampling of Chinese ESCC samples, and find recurrent ERBB4 mutations, BRCA1/2 variants, and amplification of CD274; together with high levels of genomic and T-cell receptor heterogeneity.

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Autores principales:	Ting Yan, Heyang Cui, Yong Zhou, Bin Yang, Pengzhou Kong, Yingchun Zhang, Yiqian Liu, Bin Wang, Yikun Cheng, Jiayi Li, Shixing Guo, Enwei Xu, Huijuan Liu, Caixia Cheng, Ling Zhang, Ling Chen, Xiaofei Zhuang, Yu Qian, Jian Yang, Yanchun Ma, Hongyi Li, Fang Wang, Jing Liu, Xuefeng Liu, Dan Su, Yan Wang, Ruifang Sun, Shiping Guo, Yaoping Li, Xiaolong Cheng, Zhihua Liu, Qimin Zhan, Yongping Cui
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6af70de020a14ed99c2762313c23bbe1
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spelling	oai:doaj.org-article:6af70de020a14ed99c2762313c23bbe12021-12-02T14:38:47ZMulti-region sequencing unveils novel actionable targets and spatial heterogeneity in esophageal squamous cell carcinoma10.1038/s41467-019-09255-12041-1723https://doaj.org/article/6af70de020a14ed99c2762313c23bbe12019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09255-1https://doaj.org/toc/2041-1723Esophageal squamous cell carcinoma (ESCC) is highly prevalent in China. Here, the authors carry out multi-region sampling of Chinese ESCC samples, and find recurrent ERBB4 mutations, BRCA1/2 variants, and amplification of CD274; together with high levels of genomic and T-cell receptor heterogeneity.Ting YanHeyang CuiYong ZhouBin YangPengzhou KongYingchun ZhangYiqian LiuBin WangYikun ChengJiayi LiShixing GuoEnwei XuHuijuan LiuCaixia ChengLing ZhangLing ChenXiaofei ZhuangYu QianJian YangYanchun MaHongyi LiFang WangJing LiuXuefeng LiuDan SuYan WangRuifang SunShiping GuoYaoping LiXiaolong ChengZhihua LiuQimin ZhanYongping CuiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ting Yan Heyang Cui Yong Zhou Bin Yang Pengzhou Kong Yingchun Zhang Yiqian Liu Bin Wang Yikun Cheng Jiayi Li Shixing Guo Enwei Xu Huijuan Liu Caixia Cheng Ling Zhang Ling Chen Xiaofei Zhuang Yu Qian Jian Yang Yanchun Ma Hongyi Li Fang Wang Jing Liu Xuefeng Liu Dan Su Yan Wang Ruifang Sun Shiping Guo Yaoping Li Xiaolong Cheng Zhihua Liu Qimin Zhan Yongping Cui Multi-region sequencing unveils novel actionable targets and spatial heterogeneity in esophageal squamous cell carcinoma
description	Esophageal squamous cell carcinoma (ESCC) is highly prevalent in China. Here, the authors carry out multi-region sampling of Chinese ESCC samples, and find recurrent ERBB4 mutations, BRCA1/2 variants, and amplification of CD274; together with high levels of genomic and T-cell receptor heterogeneity.
format	article
author	Ting Yan Heyang Cui Yong Zhou Bin Yang Pengzhou Kong Yingchun Zhang Yiqian Liu Bin Wang Yikun Cheng Jiayi Li Shixing Guo Enwei Xu Huijuan Liu Caixia Cheng Ling Zhang Ling Chen Xiaofei Zhuang Yu Qian Jian Yang Yanchun Ma Hongyi Li Fang Wang Jing Liu Xuefeng Liu Dan Su Yan Wang Ruifang Sun Shiping Guo Yaoping Li Xiaolong Cheng Zhihua Liu Qimin Zhan Yongping Cui
author_facet	Ting Yan Heyang Cui Yong Zhou Bin Yang Pengzhou Kong Yingchun Zhang Yiqian Liu Bin Wang Yikun Cheng Jiayi Li Shixing Guo Enwei Xu Huijuan Liu Caixia Cheng Ling Zhang Ling Chen Xiaofei Zhuang Yu Qian Jian Yang Yanchun Ma Hongyi Li Fang Wang Jing Liu Xuefeng Liu Dan Su Yan Wang Ruifang Sun Shiping Guo Yaoping Li Xiaolong Cheng Zhihua Liu Qimin Zhan Yongping Cui
author_sort	Ting Yan
title	Multi-region sequencing unveils novel actionable targets and spatial heterogeneity in esophageal squamous cell carcinoma
title_short	Multi-region sequencing unveils novel actionable targets and spatial heterogeneity in esophageal squamous cell carcinoma
title_full	Multi-region sequencing unveils novel actionable targets and spatial heterogeneity in esophageal squamous cell carcinoma
title_fullStr	Multi-region sequencing unveils novel actionable targets and spatial heterogeneity in esophageal squamous cell carcinoma
title_full_unstemmed	Multi-region sequencing unveils novel actionable targets and spatial heterogeneity in esophageal squamous cell carcinoma
title_sort	multi-region sequencing unveils novel actionable targets and spatial heterogeneity in esophageal squamous cell carcinoma
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/6af70de020a14ed99c2762313c23bbe1
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Multi-region sequencing unveils novel actionable targets and spatial heterogeneity in esophageal squamous cell carcinoma

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