Mycobacterial PIMs inhibit host inflammatory responses through CD14-dependent and CD14-independent mechanisms.

Mycobacterial PIMs inhibit host inflammatory responses through CD14-dependent and CD14-independent mechanisms.

Mycobacteria develop strategies to evade the host immune system. Among them, mycobacterial LAM or PIMs inhibit the expression of pro-inflammatory cytokines by activated macrophages. Here, using synthetic PIM analogues, we analyzed the mode of action of PIM anti-inflammatory effects. Synthetic PIM(1)...

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Autores principales: Nathalie Court, Stéphanie Rose, Marie-Laure Bourigault, Sophie Front, Olivier R Martin, Jennifer K Dowling, Elaine F Kenny, Luke O'Neill, François Erard, Valerie F J Quesniaux
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/6af7d97d62e44674902b88aab5c3e670
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