Circulating microRNAs Correlate with Multiple Myeloma and Skeletal Osteolytic Lesions

Multiple myeloma (MM) is the second most frequent hematological disease and can cause skeletal osteolytic lesions. This study aims to evaluate the expression of circulating microRNAs (miRNAs) in MM patients and to correlate those levels with clinicopathological features, including bone lesions. A pa...

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Autores principales:	Sara Reis Moura, Hugo Abreu, Carla Cunha, Cláudia Ribeiro-Machado, Carla Oliveira, Mario Adolfo Barbosa, Herlander Marques, Maria Inês Almeida
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	diagnostic biomarkers non-coding RNAs plasma cancer vertebrae Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/6af9cabb24d948fbac5ece2bd430a18a
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spelling	oai:doaj.org-article:6af9cabb24d948fbac5ece2bd430a18a2021-11-11T15:26:32ZCirculating microRNAs Correlate with Multiple Myeloma and Skeletal Osteolytic Lesions10.3390/cancers132152582072-6694https://doaj.org/article/6af9cabb24d948fbac5ece2bd430a18a2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5258https://doaj.org/toc/2072-6694Multiple myeloma (MM) is the second most frequent hematological disease and can cause skeletal osteolytic lesions. This study aims to evaluate the expression of circulating microRNAs (miRNAs) in MM patients and to correlate those levels with clinicopathological features, including bone lesions. A panel of miRNAs associated with MM onset and progression, or with bone remodeling, was analyzed in the plasma of 82 subjects (47 MM patients; 35 healthy controls). Results show that miR-16-5p, miR-20a-5p, and miR-21-5p are differently expressed between MM patients and healthy controls. Receiver operating characteristic analyses indicate that their combined expression has potential as a molecular marker (Area Under the Curve, AUC of 0.8249). Furthermore, significant correlations were found between the analyzed miRNAs and disease stage, treatment, β2 microglobulin, serum albumin and creatinine levels, but not with calcium levels or genetic alterations. In this cohort, 65.96% of MM patients had bone lesions, the majority of which were in the vertebrae. Additionally, miR-29c-3p was decreased in patients with osteolytic lesions compared with patients without bone disease. Interestingly, circulating levels of miR-29b-3p correlated with cervical and thoracic vertebral lesions, while miR-195-5p correlated with thoracic lesions. Our findings suggest circulating miRNAs can be promising biomarkers for MM diagnosis and that their levels correlate with myeloma bone disease and osteolytic lesions.Sara Reis MouraHugo AbreuCarla CunhaCláudia Ribeiro-MachadoCarla OliveiraMario Adolfo BarbosaHerlander MarquesMaria Inês AlmeidaMDPI AGarticlediagnosticbiomarkersnon-coding RNAsplasmacancervertebraeNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5258, p 5258 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diagnostic biomarkers non-coding RNAs plasma cancer vertebrae Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	diagnostic biomarkers non-coding RNAs plasma cancer vertebrae Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Sara Reis Moura Hugo Abreu Carla Cunha Cláudia Ribeiro-Machado Carla Oliveira Mario Adolfo Barbosa Herlander Marques Maria Inês Almeida Circulating microRNAs Correlate with Multiple Myeloma and Skeletal Osteolytic Lesions
description	Multiple myeloma (MM) is the second most frequent hematological disease and can cause skeletal osteolytic lesions. This study aims to evaluate the expression of circulating microRNAs (miRNAs) in MM patients and to correlate those levels with clinicopathological features, including bone lesions. A panel of miRNAs associated with MM onset and progression, or with bone remodeling, was analyzed in the plasma of 82 subjects (47 MM patients; 35 healthy controls). Results show that miR-16-5p, miR-20a-5p, and miR-21-5p are differently expressed between MM patients and healthy controls. Receiver operating characteristic analyses indicate that their combined expression has potential as a molecular marker (Area Under the Curve, AUC of 0.8249). Furthermore, significant correlations were found between the analyzed miRNAs and disease stage, treatment, β2 microglobulin, serum albumin and creatinine levels, but not with calcium levels or genetic alterations. In this cohort, 65.96% of MM patients had bone lesions, the majority of which were in the vertebrae. Additionally, miR-29c-3p was decreased in patients with osteolytic lesions compared with patients without bone disease. Interestingly, circulating levels of miR-29b-3p correlated with cervical and thoracic vertebral lesions, while miR-195-5p correlated with thoracic lesions. Our findings suggest circulating miRNAs can be promising biomarkers for MM diagnosis and that their levels correlate with myeloma bone disease and osteolytic lesions.
format	article
author	Sara Reis Moura Hugo Abreu Carla Cunha Cláudia Ribeiro-Machado Carla Oliveira Mario Adolfo Barbosa Herlander Marques Maria Inês Almeida
author_facet	Sara Reis Moura Hugo Abreu Carla Cunha Cláudia Ribeiro-Machado Carla Oliveira Mario Adolfo Barbosa Herlander Marques Maria Inês Almeida
author_sort	Sara Reis Moura
title	Circulating microRNAs Correlate with Multiple Myeloma and Skeletal Osteolytic Lesions
title_short	Circulating microRNAs Correlate with Multiple Myeloma and Skeletal Osteolytic Lesions
title_full	Circulating microRNAs Correlate with Multiple Myeloma and Skeletal Osteolytic Lesions
title_fullStr	Circulating microRNAs Correlate with Multiple Myeloma and Skeletal Osteolytic Lesions
title_full_unstemmed	Circulating microRNAs Correlate with Multiple Myeloma and Skeletal Osteolytic Lesions
title_sort	circulating micrornas correlate with multiple myeloma and skeletal osteolytic lesions
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6af9cabb24d948fbac5ece2bd430a18a
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Circulating microRNAs Correlate with Multiple Myeloma and Skeletal Osteolytic Lesions

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